The Diagnostic Value of Pleural Fluid pH

Good, James T.; Taryle, David A.; Maulitz, Robert M.; Kaplan, Robin L.; Sahn, Steven A.

doi:10.1378/chest.78.1.55

Cited by 128 publications

(82 citation statements)

References 13 publications

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“…While our study revealed very similar results as the complete success group had higher pH and glucose level and lower LDH level than the failure group, statistical significance was revealed only for the pH. The American Thoracic Society/European Respiratory Society guideline for the management of MPE recommends that pleurodesis should be limited to patients with pleural fluid pH values greater than 7.30, because of the direct correlation between low pH and poor shortterm survival [15][16][17]. This was not found to be the case in a European study that showed no association between success and LDH and pH [18].…”

Section: Discussionsupporting

confidence: 71%

Pleurodesis in malignant pleural effusions: Outcome and predictors of success

Rafei¹,

Jabak²,

Mina³

et al. 2015

Integr Cancer Sci Therap

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Malignant pleural effusion is a common clinical problem in cancer patients. Many therapeutic techniques have been investigated, including pleurodesis. Little is known about the factors that may affect the success rate of such a procedure. The main objective of this study is to assess the success rates of pleurodesis performed on malignant pleural effusions in cancer patients at AUBMC and to identify the predictors of a successful pleurodesis. Patients diagnosed with malignant pleural effusions and who have undergone pleurodesis between years 2004 and 2013 at the American University of Beirut Medical Center were identified. Relevant information including patient, tumor and pleural effusion characteristics and outcome after pleurodesis was recorded. Data analysis was done to assess the success rate of pleurodesis as well as for the presence of statistically significant association between success of pleurodesis and the different clinical characteristics. Pleurodesis success rates were as follow: 17.7% had complete success, 12.9% had partial success, 40.3% had failed pleurodesis, 3.2% died shortly after pleurodesis, and 25.8% were lost to follow-up. When this failure rate was further analyzed in terms of the different clinical markers, only two parameters were found to be associated with different success rates of pleurodesis, namely the mean pH of the pleural fluid and the tube used to perform pleurodesis. The conclusions of this study will benefit future cancer patients presenting with malignant effusions. Based on this study's results a well as those of future studies, clinicians will cautiously plan the management of malignant pleural effusion and also refine the technique used.

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Section: Discussionsupporting

confidence: 71%

Pleurodesis in malignant pleural effusions: Outcome and predictors of success

Rafei¹,

Jabak²,

Mina³

et al. 2015

Integr Cancer Sci Therap

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“…Embora alguns autores sugiram que a leitura do pH sanguíneo deva ser realizada concomitantemente com a leitura do pH pleural, outros sugerem não adotar essa conduta, apoiando-se no fato de que a acidose pleural é um fenômeno localizado (18,19,21,22) . Também não se realizou a dosagem concomitante da glicose sistêmica, pois tem-se demonstrado que as alterações ocorridas devem-se a fatores inflamatórios, restritos ao espaço pleural (19)(20)(21) .…”

Section: Discussionunclassified

Fatores preditivos para drenagem de derrames pleurais parapneumônicos em crianças

Mocelin

Fischer²

2001

J. Pneumologia

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“…A pleural fluid pH of <7.2 with a normal blood pH is found in the same diagnoses as a low pleural fluid glucose. 24 A pH of <7.2 represents a substantial accumulation of hydrogen ions, as normal pleural pH is about 7.6 because of bicarbonate accumulation in the pleural cavity. The main clinical use for the measurement of pleural pH is the identification of pleural infection.…”

Section: Differential Cell Counts On the Pleural Fluidmentioning

confidence: 99%