The diagnostic value of RNA oncomarkers in evaluation of malignant breast tumors

Abstract

The levels of the RNA oncomarkers, telomerase (hTERT), cytokeratin 19 (CK 19), and mam maglobin (MAM) have been investigated in capillary blood of female patients with mammary ductal carci noma. The study revealed overexpression of all three factors in patients with this pathology. This overexpres sion was not found in healthy donors and female patients with mammary fibroadenoma. Levels of the RNA oncomarkers return to the normal level within 10 days after successful tumor resection. These results have been used for the development of diagnostic kits, which may be applicable for differential diagnostics, screen ing and postoperation monitoring of patients with malignant breast tumors.