The diagnostic value of SE MRI and DWI of the spine in patients with monoclonal gammopathy of undetermined significance, smouldering myeloma and multiple myeloma

Dutoit, Julie C.; Vanderkerken, Matthias; Anthonissen, Joris; Dochy, Frederick; Verstraete, Koenraad

doi:10.1007/s00330-014-3324-5

Cited by 59 publications

(51 citation statements)

References 27 publications

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“…In a previous study assessing mean ADC values before and after therapy in MM patients, ADC increased by 20% in therapy responders . Horger et al found an increase of ADC by 63.9% (range, 8.7–211.3%) 3 weeks after therapy onset in therapy responders, similar to the results of previous studies . Therefore, ADC mapping has shown to be a useful tool for the assessment of the disease course of MM.…”

Section: Applications Of Quantitative Bone Marrow Mri and Mrssupporting

confidence: 62%

“…For the detection of bone marrow infiltration in MM, DW images have been previously generated with EPI sequences (b values: eg, 0, 200, 400, 600, 1000 s/mm 2 ) . As mentioned previously, tissues with high cellularity contain a small interstitial space, which causes restricted water motion . Therefore, either focal lesions or diffuse tumor cell infiltration of bone marrow can be visualized as hyperintense DW signal.…”

Section: Applications Of Quantitative Bone Marrow Mri and Mrsmentioning

confidence: 99%

“…Due to the restriction of water diffusion induced by the tightly packed surrounding adipocytes in yellow marrow compared to red marrow, ADC values appear to be low in normal bone marrow with higher yellow marrow content, ranging from 0.2–0.6 × 10 ‐3 mm 2 /s, whereas the wide measured range may be explained by experimental differences and differences in fat saturation . In MM progression, water proton diffusivity increases with the increasing water content of the bone marrow due to plasma cell infiltration causing consequent yellow marrow content decrease, therefore ADC values increase, as does the hyperintense signal on DW imaging obtained using high b‐values . In a previous study assessing mean ADC values before and after therapy in MM patients, ADC increased by 20% in therapy responders .…”

Section: Applications Of Quantitative Bone Marrow Mri and Mrsmentioning

confidence: 99%

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Quantitative MRI and spectroscopy of bone marrow

Karampinos

Ruschke

Dieckmeyer

et al. 2017

Magnetic Resonance Imaging

208

241

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Bone marrow is one of the largest organs in the human body, enclosing adipocytes, hematopoietic stem cells, which are responsible for blood cell production, and mesenchymal stem cells, which are responsible for the production of adipocytes and bone cells. Magnetic resonance imaging (MRI) is the ideal imaging modality to monitor bone marrow changes in healthy and pathological states, thanks to its inherent rich soft‐tissue contrast. Quantitative bone marrow MRI and magnetic resonance spectroscopy (MRS) techniques have been also developed in order to quantify changes in bone marrow water–fat composition, cellularity and perfusion in different pathologies, and to assist in understanding the role of bone marrow in the pathophysiology of systemic diseases (e.g. osteoporosis). The present review summarizes a large selection of studies published until March 2017 in proton‐based quantitative MRI and MRS of bone marrow. Some basic knowledge about bone marrow anatomy and physiology is first reviewed. The most important technical aspects of quantitative MR methods measuring bone marrow water–fat composition, fatty acid composition, perfusion, and diffusion are then described. Finally, previous MR studies are reviewed on the application of quantitative MR techniques in both healthy aging and diseased bone marrow affected by osteoporosis, fractures, metabolic diseases, multiple myeloma, and bone metastases. Level of Evidence: 3 Technical Efficacy: Stage 2J. Magn. Reson. Imaging 2018;47:332–353.

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Section: Applications Of Quantitative Bone Marrow Mri and Mrssupporting

confidence: 62%

Section: Applications Of Quantitative Bone Marrow Mri and Mrsmentioning

confidence: 99%

Section: Applications Of Quantitative Bone Marrow Mri and Mrsmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative MRI and spectroscopy of bone marrow

Karampinos

Ruschke

Dieckmeyer

et al. 2017

Magnetic Resonance Imaging

208

241

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“…Similarly, a higher ADC for T10 than for L3 was found by Dutoit et al . ; these results are summarized in Table . A slow decrease of the ADC with age was observed by Yeung et al .…”

Section: Adcs Of Normal‐appearing Vertebral Bone Marrowmentioning

confidence: 92%

Diffusion imaging of the vertebral bone marrow

Dietrich

Geith²,

Reiser

et al. 2015

NMR in Biomedicine

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Diffusion-weighted MRI (DWI) of the vertebral bone marrow is a clinically important tool for the characterization of bone-marrow pathologies and, in particular, for the differentiation of benign (osteoporotic) and malignant vertebral compression fractures. DWI of the vertebral bone marrow is, however, complicated by some unique MR and tissue properties of vertebral bone marrow. Due to both the spongy microstructure of the trabecular bone and the proximity of the lungs, soft tissue, or large vessels, substantial magnetic susceptibility variations occur, which severely reduce the magnetic field homogeneity as well as the transverse relaxation time T , and thus complicate MRI in particular with echoplanar imaging (EPI) techniques. Therefore, alternative diffusion-weighting pulse sequence types such as single-shot fast-spin-echo sequences or segmented EPI techniques became important alternatives for quantitative DWI of the vertebral bone marrow. This review first describes pulse sequence types that are particularly important for DWI of the vertebral bone marrow. Then, data from 24 studies that made diffusion measurements of normal vertebral bone marrow are reviewed; summarizing all results, the apparent diffusion coefficient (ADC) of normal vertebral bone marrow is typically found to be between 0.2 and 0.6 × 10 mm /s. Finally, DWI of vertebral compression fractures is discussed. Numerous studies demonstrate significantly greater ADCs in osteoporotic fractures (typically between 1.2 and 2.0 × 10 mm /s) than in malignant fractures or lesions (typically 0.7-1.3 × 10 mm /s). Alternatively, several studies used the (qualitative) image contrast of diffusion-weighted acquisitions for differentiation of lesion etiology: a very good lesion differentiation can be achieved, particularly with diffusion-weighted steady-state free precession sequences, which depict malignant lesions as hyperintense relative to normal-appearing vertebral bone marrow, in contrast to hypointense or isointense osteoporotic lesions. Copyright © 2015 John Wiley & Sons, Ltd.

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“…It is more and more applied in oncologic imaging, apparent diffusion coefficient (ADC) being a parameter used to measure the magnitude of diffusion of water molecules within biologic tissues . Previous studies investigated the role of DWI in the differentiation between benign and malignant skeletal conditions, with promising results . However, studies performed in the spine had small sample size or lacked histology comparison .…”

mentioning

confidence: 99%