The diagnostic value of shear wave elastography for parathyroid lesions and comparison with cervical lymph nodes

Abstract

Aims: The aim of this study was to prospectively assess the feasibility of the Virtual Touch tissue imaging quantification (VTIQ) method of shear wave elastography (SWE) for the discrimination of parathyroid lesions and to compare the lesions’ stiffness with that of cervical lymph nodes.Materials and methods: SWE using VTIQ was performed on 66 patients with 87 histopathologically proven parathyroid lesions (54 parathyroid adenomas and 33 parathyroid hyperplasia) and 29 patients with 31 inflammatory cervical lymph nodes. The mean SWVs of the lesions were compared and receiver operating characteristic (ROC) curve analysis was used to evaluate diagnostic performance.Results: The mean SWV of parathyroid adenomas (2.16±0.33 m/s) differed significantly from those of parathyroid hyperplasia and lymph nodes (1.75±0.28 m/s and 1.86±0.37 m/s respectively, p<0.001). Selecting a cutoff value of 1.92 m/s for diagnosing adenoma led to 80% sensitivity and 82% specificity (area under the curve [AUC]: 0.832 [95% confidence interval (CI): 0.742–0.921], p< 0.001).Conclusions: The VTIQ method of SWE can contribute to the differentiation of parathyroid adenoma from parathyroid hyperplasia and cervical lymphnodes.

Shear Wave Elastography versus Strain Elastography in Diagnosing Parathyroid Adenomas

“…Most available preoperative localization techniques for PHPT are ultrasonography (US) and technitium-99 m sestamibi scintigraphy scan [17]. US is widely available, noninvasive, cheap, and repeatable [18,19], and it can be used for positive diagnosis and also for therapeutic interventions (fine-needle aspiration and percutaneous interventions-ethanol, radio frequency, or laser ablation) [20]. Additional applications of US such as color and power Doppler, 3D imaging, contrast-enhanced ultrasonography, and elastography have increased the diagnostic value of ultrasound in diagnosing hyperparathyroidism [18], by decreasing the false-positive cases.…”

Efficacy of Ultrasound and Shear Wave Elastography for the Diagnosis of Breast Cancer–Related Lymphedema

“…The bioimpedance analysis has been reported to be effective for early diagnosis; however, it is not readily available in all clinics . Shear wave elastography is becoming widely available and is increasingly being used in routine clinical practice because of its facilitation of the diagnosis of organ and system diseases . The hypothesis of this study was therefore based on the feasibility of SWE in the early diagnosis of limb lymphedema by using L‐Dex measurements and clinical findings as the reference standards.…”

“…9,14,15,22 Shear wave elastography is becoming widely available and is increasingly being used in routine clinical practice because of its facilitation of the diagnosis of organ and system diseases. [16][17][18] The hypothesis of this study was therefore based on the feasibility of SWE in the early diagnosis of limb lymphedema by using L-Dex measurements and clinical findings as the reference standards. A review of the literature indicates that this study was the first to investigate the role of SWE in the diagnosis of latent lymphedema.…”

“…Shear wave elastography (SWE) is an ultrasound (US)‐based imaging modality for evaluating tissue stiffness . Acoustic radiation forces from the transducer generate shear waves through the tissue.…”

“…Shear wave elastography (SWE) is an ultrasound (US)-based imaging modality for evaluating tissue stiffness. [16][17][18] Acoustic radiation forces from the transducer generate shear waves through the tissue. Information about tissue stiffness is derived from the values for the speeds of those shear waves, which are expressed as the shear wave velocity (SWV) in meters per second.…”