The diagnostic value of specific IgE to Ara h 2 to predict peanut allergy in children is comparable to a validated and updated diagnostic prediction model

Klemans, Rob J.B.; Otte, Dianne; Knol, Mirjam J.; Knol, Edward F.; Meijer, Y.; Gmelig-Meyling, F.H.J.; Bruijnzeel-Koomen, Carla A.F.M.; Knulst, André C.; Pasmans, Suzanne G.M.A.

doi:10.1016/j.jaci.2012.08.010

Cited by 120 publications

(134 citation statements)

References 35 publications

Supporting

Mentioning

115

Contrasting

Unclassified

Order By: Relevance

“…Interestingly, we found significantly higher levels of Ara h 6-specific IgE compared with IgE levels specific for Ara h 2, possibly due to the higher IgE affinity and IgE epitope availability of the purified natural Ara h 6 compared with recombinant Ara h 2 presented on the ImmunoCAP ISAC 112. In contrast to earlier studies, recent studies have increasingly suggested a positive correlation between the severity of symptoms and the level of specific IgE, especially to Ara h 2, but also to Ara h 1 and Ara h 3 [3,6,9,23]. We showed that patients experiencing anaphylaxis after exposure to peanut had significantly higher levels of sIgE against Ara h 1, Ara h 2, Ara h 3 and Ara h 6 as compared to patients suffering from milder symptoms such as OAS, although not all patients with severe reactions had high IgE levels to Ara h 2.…”

Section: Discussionmentioning

confidence: 96%

“…The diagnostic value of Ara h 6, which has only recently become available on ImmunoCAP ISAC, has been shown to be equivalent to Ara h 2 with a positive predictive value of 95% [7]. Although only Ara h 2 is considered as a predictor of clinical reactivity to peanut [8,9,10], polysensitization to Ara h 2 and Ara h 1 and/or Ara h 3 appeared to be predictive of more severe reactions [11,12,13]. …”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Ackerbauer

Bublin

Radauer

et al. 2015

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Peanut allergy develops after primary sensitization to peanut allergens and/or IgE cross-sensitization with homologous allergens from various plants. Therefore, heterogeneous patterns of sensitization to individual peanut allergens are observed in different countries. The aim of this study was to examine the IgE sensitization patterns of Austrian peanut-allergic patients. Methods: Sera from 65 peanut-allergic patients and 20 peanut-tolerant atopics were obtained in four Austrian allergy clinics.Sensitization patterns against peanut allergens Ara h 1-3, 6, 8 and 9 were identified by ImmunoCAP and ImmunoCAP ISAC. Results: Austrian peanut-allergic patients were sensitized to Ara h 2 and 6 (71%), followed by Ara h 1 (62%), Ara h 8 (45%), Ara h 3 (35%) and Ara h 9 (11%). All sera containing Ara h 2-specific IgE were also positive for Ara h 6, with Ara h 6-specific IgE levels significantly (p < 0.05) higher compared with Ara h 2. Twelve percent displayed IgE reactivity exclusively to Ara h 8. Peanut extract and Ara h 8 showed low diagnostic specificities of 25 and 10%, respectively. The other peanut allergens showed 100% specificity. Diagnostic sensitivities determined by ImmunoCAP ISAC and ImmunoCAP were highly similar for Ara h 2, 3 and 8. Conclusions: Themajority of symptomatic peanut-allergic patients are sensitized to Ara h 2 and Ara h 6. In peanut-symptomatic patients with additional birch pollen allergy, other peanut allergens, especially Ara h 8, should be tested when IgE reactivity to Ara h 2 is absent.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Ackerbauer

Bublin

Radauer

et al. 2015

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…When validated in the same centre, the model showed an AUC of 0.97 to predict peanut allergy (33). However, this prediction model was not able to predict peanut allergy in a Dutch study (34). A prediction model has not yet been developed for cashew nut allergy.…”

Section: Algorithm For the Diagnosis Of Cashew Nut Allergymentioning

confidence: 96%

Systematic review on cashew nut allergy

Valk

Dubois

Wijk

et al. 2014

Allergy

View full text Add to dashboard Cite

Recent studies on cashew nut allergy suggest that the prevalence of cashew nut allergy is increasing. Cashew nut consumption by allergic patients can cause severe reactions, including anaphylaxis. This review summarizes current knowledge on cashew nut allergy to facilitate timely clinical recognition and to promote awareness of this emerging food allergy amongst clinicians. The goal of this study is to present a systematic review focused on the clinical aspects of allergy to cashew nut including the characteristics of cashew nut, the prevalence, allergenic components, cross-reactivity, diagnosis and management of cashew nut allergy. The literature search yielded 255 articles of which 40 met our selection criteria and were considered to be relevant for this review. The 40 articles included one prospective study, six retrospective studies and seven case reports. The remaining 26 papers were not directly related to cashew nut allergy. The literature suggests that the prevalence of cashew nut allergy is increasing, although the level of evidence for this is low. A minimal amount of cashew nut allergen may cause a severe allergic reaction, suggesting high potency comparable with other tree nuts and peanuts. Cashew allergy is clearly an underestimated important healthcare problem, especially in children.Although peanut allergy has been on the increase for two decades or more, studies indicate that cashew nut is also becoming an important food allergen (1, 2). The rapid increase in consumption of cashew nuts and the change in eating and cooking habits may be responsible for the increasing significance of cashew nut allergy (2).In this paper, we summarize the relevant information available on epidemiology, allergen components, clinical features, diagnosis, clinical and in vitro cross-sensitization and management of cashew nut allergy. Data sources and literature searchIn our search, we adhered to the methods and procedures of the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines for reporting this systematic review, excluding irrelevant items. Registration number in PROSPERO is CRD42013004047.We used Ovid MEDLINE and EMBASE databases to identify relevant articles using the string: (Anacardi* sensitiv*) OR allerg*): de, ab, ti for EMBASE. We also checked references to relevant articles ('snowballing').We aimed to include studies focused on the clinical aspects of cashew nut allergy. We considered only studies in English. There was no restriction on publication date. Mouse model studies were excluded. Initially, all articles on cashew nut allergy or on cashew nuts were included. Thereafter articles on contact dermatitis, genetics, product labelling, poisoning, detection methods and possible medicinal effects of cashew plants were excluded. Forty of 255 articles found with the literature search (244 articles) and by 'snowballing (11 articles) were considered relevant for the review. Of these 40 articles, one article was a prospective study and six articles were retrospective stu...

show abstract

“…Klemans и соавт. показали, что предиктором тяже лых реакций у взрослых является наличие спе ци-фи чес ких IgE к рекомбинантному аллергену арахиса Ara h6 [10]. Известен случай анафилаксии у ребенка с моносенсибилизацией к аллергену rAra h6 [11].…”

Section: российский вестник перинатологии и педиатрии 4 2016 Rossiyunclassified

“…Так, сенсибилизация к аллергену арахиса rAra h2 в Европе среди пациентов детского возраста составляет более 60% и является ключевым маркером аллергических реакций к арахису [14][15][16].…”

Section: результаты и обсуждениеunclassified

Specific features of sensitization to recombinant peanut allergens in children with anaphylaxis

Шуляева¹,

Пампура²,

Окунева³

2016

Ross. vestn. perinatol. pediatr.

View full text Add to dashboard Cite

The diagnostic value of specific IgE to Ara h 2 to predict peanut allergy in children is comparable to a validated and updated diagnostic prediction model

Cited by 120 publications

References 35 publications

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Component-Resolved IgE Profiles in Austrian Patients with a Convincing History of Peanut Allergy

Systematic review on cashew nut allergy

Specific features of sensitization to recombinant peanut allergens in children with anaphylaxis

Contact Info

Product

Resources

About