The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese

Yang, Lin; Luo, Shuoming; Huang, Gan; Peng, Jian; Li, Xia; Yan, Xiang; Lin, Jian; Wenzlau, Janet M.; Davidson, Howard W.; Hutton, John C.; Zhou, Zhiguang

doi:10.1002/dmrr.1128

Cited by 87 publications

(122 citation statements)

References 16 publications

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“…The frequency of ZnT8 Ab may be related to some HLA differences, and be similar in similar populations, as in the study of Polish neighbours, Czech T1DM children, the prevalence of this Ab was similar to our results [18]. Interestingly, in Chinese T1D subject ZnT8 Ab and IA-2 Ab were less prevalent than in Caucasian populations, but similar to Japanese [27].…”

Section: Discussionsupporting

confidence: 90%

Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes

Głowińska‐Olszewska

Michalak

Łuczyński

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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Background: The aim of this study was to assess the prevalence of diabetes and other organ-specific autoantibodies (Ab) associated with various autoimmune conditions, in Polish children with type 1 diabetes mellitus (T1DM). Methods: In this study 114 patients, aged 13.4 years, with mean diabetes duration 5.2 years were included. Ab to islet cell antigens: glutamic acid decarboxylase (GAD), insulinoma antigen 2 (IA-2), zinc transporter 8 (ZnT8), together with thyroid peroxidase Ab (TPO Ab), thyroglobulin Ab (Tg Ab), tissue transglutaminase Ab (tTG Ab) and 21-hydroxylase Ab (21-OH Ab) were measured. Results: The prevalence of at least one diabetes associated Ab was found in 87%, with the highest prevalence of 64% for ZnT8 Ab. In patients with disease duration < 5 years, at least one antibody was present in 90%, the most prevalent was ZnT8 Ab (72%). In patients with duration > 10 years, 50% had at least one antibody. The prevalence of other than islet cell autoimmunity was high (34%). Thyroid Ab were detected in 26% patients, 42% in girls vs. 8% in boys, p < 0.001. tTG Ab were found in 11% patients, with a greater prevalence in children with early onset (p = 0.01). 21-OH Ab were found in 2.6% T1DM patients.

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Section: Discussionsupporting

confidence: 90%

Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes

Głowińska‐Olszewska

Michalak

Łuczyński

et al. 2016

Journal of Pediatric Endocrinology and Metabolism

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“…Serum levels of C-peptide and C-reactive protein were quantified using a chemiluminescence immunoassay on a Bayer 180SE Automated Chemiluminescence System (Bayer AG, Leverkusen, Germany) and an immunoturbidimetric assay (Orion Diagnostica, Espoo, Finland), respectively. The titers of GADA, IA2A, and ZnT8A were determined by in-house radioligand assays, as previously described (22,23).…”

Section: Clinical and Biochemical Assessmentsmentioning

confidence: 99%

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With β-Cell Autoimmunity in Patients With Type 1 Diabetes

et al. 2014

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Type 1 diabetes (T1D) is an autoimmune disease resulting from the self-destruction of insulin-producing β-cells. Reduced neutrophil counts have been observed in patients with T1D. However, the pathological roles of neutrophils in the development of T1D remain unknown. Here we show that circulating protein levels and enzymatic activities of neutrophil elastase (NE) and proteinase 3 (PR3), both of which are neutrophil serine proteases stored in neutrophil primary granules, were markedly elevated in patients with T1D, especially those with disease duration of less than 1 year. Furthermore, circulating NE and PR3 levels increased progressively with the increase of the positive numbers and titers of the autoantibodies against β-cell antigens. An obvious elevation of NE and PR3 was detected even in those autoantibody-negative patients. Increased NE and PR3 in T1D patients are closely associated with elevated formation of neutrophil extracellular traps. By contrast, the circulating levels of α1-antitrypsin, an endogenous inhibitor of neutrophil serine proteases, are decreased in T1D patients. These findings support an early role of neutrophil activation and augmented neutrophil serine proteases activities in the pathogenesis of β-cell autoimmunity and also suggest that circulating NE and PR3 may serve as sensitive biomarkers for the diagnosis of T1D.

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“…Zinc transporter-8 -a protein that moves this essential mineral into cellsis another autoantigen that the immune system targets in some people with type 1 diabetes. 7 Autoantibodies against zinc transporter-8 were seen mainly in patients with SAID (27.3% compared with <2% in other clusters). 3 Treatment patterns also differed between some clusters.…”

Section: Five Clustersmentioning

confidence: 98%

Precision diabetes treatment comes a step closer

Greener¹

2018

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The diagnostic value of zinc transporter 8 autoantibody (ZnT8A) for type 1 diabetes in Chinese

Cited by 87 publications

References 16 publications

Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes

Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes

Increased Neutrophil Elastase and Proteinase 3 and Augmented NETosis Are Closely Associated With β-Cell Autoimmunity in Patients With Type 1 Diabetes

Precision diabetes treatment comes a step closer

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