The Diagnostic Yield of Lymph Node Biopsy

Peripheral Lymphadenopathy as a Primary Presenting Sign: A Study of 324 Cases from Asir Region

“…Many reports summarizing the distribution patterns of various causes of lymphadenopathy among populations of various regions of the world including western countries [2][3][4][5], the Middle East [6], and the Kingdom of Saudi Arabia [7][8][9][10] are present in the medical literature.…”

Histologic Patterns of Lymphadenopathy in the Eastern Province of Saudi Arabia

“…16,17 The cervical lymph nodes also possess the best diagnostic features, compared to inguinal or axillary nodes. 18,43 The least common site of involvement is mesenteric, accounting for only 2.2% of the cases. Supraclavicular lymph nodes have, in particular, the best diagnostic yield of all peripheral lymph nodes with an 85.2 to 90% yield.…”

The diagnostic value of biopsy of small peripheral lymph nodes in patients with suspected lymphoma

“…There are many causes of DIC, such as sepsis, cancer, or pregnancy [1,2]. Its management, still unsatisfactory due to the lack of an effective therapy, is mainly based on the treatment of the underlying condition along with the administration of fresh-frozen plasma (FFP) and replacement therapy (such as anti-thrombin [AT]) [3,4]. Recently, the correlation between sepsis and coagulation abnormalities has been intensively investigated [5][6][7]; in septic patients with DIC, substitution therapy with activated recombinant protein C (ar-PC) has been proven to be effective, but with an increase in bleeding [8,9].…”

“…Of interest, in Patients 2 and 3, the diagnostic lymph node came from the inguinal area-a region often ignored for biopsy because of the frequency of benign inflammatory findings in adults [2,4]. In patients in whom a lymphoproliferative disorder is suspected, especially if there is evident retroperitoneal adenopathy, the diagnostic yield of inguinal node biopsy may be increased.…”

“…Further, it has been shown that, at the time of pathologic examination, the size of a superficial lymph node removed surgically does not always correlate with diagnostic yield [4]. Small, nonpalpable lymph nodes in Hodgkin lymphoma have been found to contain focal involvement when examined microscopically [6].…”