2012
DOI: 10.3892/ijo.2012.1690
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The dichloromethane extract of the ethnomedicinal plant Neurolaena lobata inhibits NPM/ALK expression which is causal for anaplastic large cell lymphomagenesis

Abstract: Abstract. The present study investigates extracts of Neuolaena lobata, an anti-protozoan ethnomedicinal plant of the Maya, regarding its anti-neoplastic properties. Firstly, extracts of increasing polarity were tested in HL-60 cells analyzing inhibition of cell proliferation and apoptosis induction. Secondly, the most active extract was further tested in anaplastic large cell lymphoma (ALCL) cell lines of human and mouse origin. The dichloromethane extract inhibited proliferation of HL-60, human and mouse ALCL… Show more

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Cited by 9 publications
(14 citation statements)
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References 46 publications
(47 reference statements)
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“…All rights reserved. 2001;Franç ois et al, 1996;Passreiter and Isman, 1997;Unger et al, 2013;Walshe-Roussel et al, 2013). In addition, organic fractions of N. lobata hydroalcoholic extracts demonstrated anti-ulcerogenic and anti-nociceptive effect in vivo (Gracioso et al, 1998(Gracioso et al, , 2000.…”
Section: Introductionmentioning
confidence: 94%
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“…All rights reserved. 2001;Franç ois et al, 1996;Passreiter and Isman, 1997;Unger et al, 2013;Walshe-Roussel et al, 2013). In addition, organic fractions of N. lobata hydroalcoholic extracts demonstrated anti-ulcerogenic and anti-nociceptive effect in vivo (Gracioso et al, 1998(Gracioso et al, , 2000.…”
Section: Introductionmentioning
confidence: 94%
“…ex Cass. was collected in February 2011 in Guatemala, Departamento Petén, near the north-western shore of Lago Petén Itzá, 0.5 km NNW of San José in the area of the Chakmamantok-rock formation (16 59 16 N, 89 53 45 W) and within the botanical garden of the Institute for Ethnobiology (Unger et al, 2013). Voucher specimens (leg.…”
Section: Plant Materialsmentioning
confidence: 99%
“…ex Cass. was collected in February 2011 in Guatemala, Departamento Petén, near the north-western shore of Lago Petén Itzá, 0.5 km NNW of San José in the area of the Chakmamantok-rock formation (16°59 16 N, 89°53 45 W) and within the botanical garden of the Institute for Ethnobiology (Unger et al, 2013). Voucher specimens (No.…”
Section: Plant Materials Fine Chemicals and Antibodiesmentioning
confidence: 99%
“…Protein concentration was determined by Bradford assay (Protein Assay Dye reagent Concentrate, BioRad, Hercules, CA, USA). SDS electrophoresis, electrotransfer to PVDF and nitrocellulose membranes (Whatman, Dassel, Germany), and antibody reactions were as described by Unger et al (2013).…”
Section: Western Blottingmentioning
confidence: 99%
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