The Dicopper(<scp>II</scp>) Complex of the Novel Asymmetric Dinucleating Ligand Hpy3asym as a Structural Model of Catechol Oxidase

Koval, Iryna A.; Pursche, Daniel; Stassen, Arno F.; Gámez, Patrick; Krebs, Bernt; Reedijk, J.

doi:10.1002/ejic.200200650

Cited by 62 publications

(36 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The proligand Hpy2ald was synthesized as previously described [12]. The infrared spectra of the complexes in the 4000-300 cm À1 range were recorded on a Bruker 330V IR spectrophotometer equipped with a Golden Gate Diamond.…”

Section: Methodsmentioning

confidence: 99%

New dinuclear Co(II) and Mn(II) complexes of the phenol-based compartmental ligand containing formyl and amine functions: structural, spectroscopic and magnetic properties

Koval

Huisman

Stassen

et al. 2004

Inorganica Chimica Acta

Self Cite

View full text Add to dashboard Cite

The phenol-based compartmental ligand Hpy2ald contains a tridentate amino arm and a weak donor aldehyde group at the 2 0 and at the 6 0 positions of the phenol ring, respectively. This ligand reacts with cobalt(II) perchlorate, cobalt(II) tetrafluoroborate and manganese(II) perchlorate, yielding dinuclear complexes, where two metal ions are doubly bridged by two deprotonated cresolate moieties. The coordination environment around the metal ions is then completed to a very distorted octahedron by three nitrogen donor atoms from the pendant amino arm and the oxygen atom of the aldehyde group. The crystal structures of the complexes, their spectroscopic and magnetic properties are reported.

show abstract

Section: Methodsmentioning

confidence: 99%

New dinuclear Co(II) and Mn(II) complexes of the phenol-based compartmental ligand containing formyl and amine functions: structural, spectroscopic and magnetic properties

Koval

Huisman

Stassen

et al. 2004

Inorganica Chimica Acta

Self Cite

View full text Add to dashboard Cite

show abstract

“…24,96 In some cases the ligands have one structural variation in one arm, 23,24,96 in others one donor arm has been omitted. 19,[104][105][106] Often the vacant coordination site is found to be occupied by water or solvent molecules in the complex. 105,106 …”

Section: Biomimetics Of Dinuclear Metallohydrolasesmentioning

confidence: 99%

Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

et al. 2014

View full text Add to dashboard Cite

An enhanced understanding of the metal ion binding and active site structural features of phosphoesterases such as the glycerophosphodiesterase from Enterobacter aerogenes (GpdQ), and the organophosphate degrading agent from Agrobacterium radiobacter (OpdA) have important consequences for potential applications. Coupled with investigations of the metalloenzymes, programs of study to synthesise and characterise model complexes based on these metalloenzymes can add to our understanding of structure and function of the enzymes themselves. This review summarises some of our work and illustrates the significance and contributions of model studies to knowledge in the area.

show abstract

“…It has been proposed that these asymmetric complexes are not only more appropriate functional models for the active site of phosphoesterase enzymes, but also that they exhibit enhanced catalytic rates compared with their symmetric counterparts. [1][2][3] Ligands used to generate purple acid phosphatase, 1,4-10 phosphoesterase, 11 urease, 12,13 catechol oxidase 14 and manganese catalase biomimetics 15,16 have been reported. Some ligands engender both a hard and a soft coordination site resulting in heterodinuclear complexes as, for example, models for purple acid phosphatase metalloenzymes.…”

Section: Introductionmentioning

confidence: 99%

Asymmetric zinc(ii) complexes as functional and structural models for phosphoesterases

et al. 2013

View full text Add to dashboard Cite

We report two asymmetric ligands for the generation of structural and functional dinuclear metal complexes as phosphoesterase mimics. Two zinc(II) complexes, [Zn 2 (CH 3 L4)(CH 3 CO 2 ) 2 ] + (CH 3 HL4 = 2-(((2-methoxyethyl)( pyridin-2-ylmethyl)amino)methyl)-4-methyl-6-((( pyridin-2-ylmethyl)amino)methyl)-phenol) and [Zn 2 (CH 3 L5)(CH 3 CO 2 ) 2 ] + (CH 3 HL5 = 2-(((2-methoxyethyl)( pyridine-2-ylmethyl)amino)-methyl)-4-methyl-6-((( pyridin-2-ylmethyl)(4-vinylbenzyl)amino)methyl)phenol) were synthesized and characterized by X-ray crystallography. The structures showed that the ligands enforce a mixed 6,5-coordinate environment in the solid state. 1 H-, 13 C-and 31 P-NMR, mass spectrometry and infrared spectroscopy were used to further characterize the compounds in the solid state and in solution. The zinc (II) complexes hydrolyzed the organophosphate substrate bis-(2,4-dinitrophenol)phosphate (BDNPP), the nucleophile proposed to be a terminal water molecule ( pK a 7.2). The ligand CH 3 HL4 was immobilised on Merrifield resin and its zinc(II) complex generated. Infrared spectroscopy, microanalysis and XPS measurements confirmed successful immobilisation, with a catalyst loading of ∼1.45 mmol g −1 resin. The resin bound complex was active towards BDNPP and displayed similar pH dependence to the complex in solution.

show abstract

The Dicopper(II) Complex of the Novel Asymmetric Dinucleating Ligand Hpy3asym as a Structural Model of Catechol Oxidase

Cited by 62 publications

References 15 publications

New dinuclear Co(II) and Mn(II) complexes of the phenol-based compartmental ligand containing formyl and amine functions: structural, spectroscopic and magnetic properties

New dinuclear Co(II) and Mn(II) complexes of the phenol-based compartmental ligand containing formyl and amine functions: structural, spectroscopic and magnetic properties

Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

Asymmetric zinc(ii) complexes as functional and structural models for phosphoesterases

Contact Info

Product

Resources

About