2017
DOI: 10.1177/1744806917697010
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The dietary constituent resveratrol suppresses nociceptive neurotransmission via the NMDA receptor

Abstract: BackgroundAlthough we have previously reported that intravenous resveratrol administration inhibits the nociceptive neuronal activity of spinal trigeminal nucleus caudalis neurons, the site of the central effect remains unclear. The aim of the present study was to examine whether acute intravenous resveratrol administration in the rat attenuates central glutamatergic transmission of spinal trigeminal nucleus caudalis neurons responding to nociceptive mechanical stimulation in vivo, using extracellular single-u… Show more

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Cited by 22 publications
(13 citation statements)
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“…This inhibitory effect was reversed after approximately 20 min . As iontophoretic application of glutamate‐ and NMDA‐induced SpVc WDR neuronal discharges was significantly inhibited by intravenous administration of resveratrol, we speculate that resveratrol transiently suppresses noxious stimulation‐induced glutaminergic neurotransmission of SpVc WDR neurons via postsynaptic central NMDA receptors .…”
Section: Discussionmentioning
confidence: 77%
See 1 more Smart Citation
“…This inhibitory effect was reversed after approximately 20 min . As iontophoretic application of glutamate‐ and NMDA‐induced SpVc WDR neuronal discharges was significantly inhibited by intravenous administration of resveratrol, we speculate that resveratrol transiently suppresses noxious stimulation‐induced glutaminergic neurotransmission of SpVc WDR neurons via postsynaptic central NMDA receptors .…”
Section: Discussionmentioning
confidence: 77%
“…In fact, Takehana et al . demonstrated that iontophoretic application of glutamate and N ‐methyl‐ d ‐aspartate (NMDA) induced SpVc WDR neuronal discharges which were significantly inhibited by intravenous administration of resveratrol. Taken together, these findings therefore suggest that systemic administration of resveratrol could attenuate the acute inflammation‐induced neuronal activities of trigeminal spatial distribution in the SpVc and C1 horn neurons (inputs from the area of innervated trigeminal nerve), in addition to its effects on chronic inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…Among glutamate receptors, NMDARs are widely distributed and are one of the most important types of amino acid receptors in the central nervous system. Studies have also indicated that neurons in the Vc are activated following orofacial nociceptive stimulation and that neuronal glutamate NMDARs are involved in signal transmission (Wong et al, 2014; Takehana et al, 2017). Among all the subunits of NMDARs, NR2B subunit phosphorylation has to be demonstrated in previous studies to play a more important role than other subunits in the nociceptive transmission and neuron-astrocytic interaction (Bursztajn et al, 2004; Kato et al, 2006; Wang et al, 2011).…”
Section: Discussionmentioning
confidence: 99%
“…65,66 Additionally, prior studies revealed that resveratrol suppressed glutamatergic neurotransmission via the NMDA receptor in vivo and inhibited calcium channels. 67,68 Hence, mitochondrial sirtuins, OPA1 mRNA, and mitCN showed suppressed upregulation in the treatment group receiving NMDA with resveratrol, possibly through the inhibition of glutamatergic neurotransmission and/or calcium channels via NMDA receptors. Further studies will be necessary to confirm the connection between sirtuin expression and mitochondrial genes in mediating the protection from retinal damage.…”
Section: Discussionmentioning
confidence: 94%