The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells

Xie, Fang; Lang, Qingyu; Zhou, Mei; Zhang, Haoxing; Zhang, Zhishun; Zhang, Yifeng; Wan, Bo; Huang, Qiang; Liu, Yu

doi:10.1016/j.ejps.2012.03.002

Cited by 43 publications

(30 citation statements)

References 44 publications

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“…Furthermore, jaceosidin is proved to specifically inhibit HPV16-harboring cervical carcinoma cell lines CaSki and SiHa and exert only very little or no inhibition in HPV18-positive HeLa cells and HPV-negative C33A cells (Lee et al, 2005 DOI:http://dx.doi.org/10.7314/APJCP.2014.15.19.8007 Characterisitics of Cytotoxicity of Flavonoids on Cervical Cancer Cells apoptosis of HPV18-positive HeLa cells exhibiting only mild cytotoxicity at high doses in HPV16-harboring cells and no effect on HPV-free C33A cells (Xie F et al, 2012;Krifa et al, 2013;Ham et al, 2014). It is probable that jaceosidin can specifically downregulate the E6 and E7 oncoproteins of HPV type 16 and luteolin those of HPV type 18.…”

Section: Flavonesmentioning

confidence: 99%

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Sak¹

2014

Asian Pacific Journal of Cancer Prevention

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Cervical cancer is the most common gynecologic malignancy worldwide and development of new therapeutic strategies and anticancer agents is an urgent priority. Plants have remained an important source in the search for novel cytotoxic compounds and several polyphenolic flavonoids possess antitumor properties. In this review article, data about potential anticarcinogenic activity of common natural flavonoids on various human cervical cancer cell lines are compiled and analyzed showing perspectives for the use of these secondary metabolites in the treatment of cervical carcinoma as well as in the development of novel chemotherapeutic drugs. Such anticancer effects of flavonoids seem to differentially depend on the cellular type and origin of cervical carcinoma creating possibilities for specific targeting in the future. Besides the cytotoxic activity per se, several flavonoids can also contribute to the increase in efficacy of conventional therapies rendering tumor cells more sensitive to standard chemotherapeutics and irradiation. Although the current knowledge is still rather scarce and further studies are certainly needed, it is clear that natural flavonoids may have a great potential to benefit cervical cancer patients.

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Section: Flavonesmentioning

confidence: 99%

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Sak¹

2014

Asian Pacific Journal of Cancer Prevention

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“…1H), were found to potently suppress endogenous Aurora B activity [24,25]. Natural product Fisetin and Luteolin were also reported to inhibit Aurora B kinase activity in cancer cells [26,27]. In addition to AZD1152, AT9283, PHA-739358, MLN8237 and ENMD2076 (Fig.…”

Section: Introductionmentioning

confidence: 91%

“…The proteins were purified by affinity chromatography using Ni-NTA agarose. The assay is described in a previous study [27,30].…”

Section: Radiometric Assay For the In Vitro High-throughput Screenmentioning

confidence: 99%

“…In our previous study, we conducted an in vitro high-throughput screening (HTS) radiometric assay to discover novel Aurora B inhibitors [27,30,31] After two rounds of screening a pool of smallmolecule compounds, several candidates were selected based on their inhibitory activity and chemical structures. In this study, one of these lead compounds, a small-molecule benzofuran derivative (S6), was identified as an inhibitor that targets Aurora B in the physiological environment.…”

Section: Introductionmentioning

confidence: 99%

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In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor

Xie

Zhu

Zhang

et al. 2015

European Journal of Medicinal Chemistry

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“…S druge strane, nije uočen proapoptotski efekat luteolina prema humanim PBMC [196]. Zapaženo je i da je luteolin inhibirao aktivnost Aurora B serin/treonin kinaze, jednog od regulatora mitoze u tretiranim HeLa ćelijama [195].…”

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In vitro investigation of antitumor activities of extracts of endemic plant species Helichrysum zivojini ?ernjavski et So?ka U

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The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells

Cited by 43 publications

References 44 publications

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

Characteristic Features of Cytotoxic Activity of Flavonoids on Human Cervical Cancer Cells

In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor

In vitro investigation of antitumor activities of extracts of endemic plant species Helichrysum zivojini ?ernjavski et So?ka U

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