The Difference in Effect of Arabica Coffee Gayo Beans and Leaf (Coffea Arabica Gayo) Extract on Decreasing Blood Sugar Levels in Healthy Mice

Abstract

BACKGROUND: High incidence rate of diabetes mellitus (DM) and increased incidence of complications from DM as well as the use of less effective antidiabetic drugs and high financing to treat demands alternative therapy.
 AIM: This study was conducted to determine the difference in the effect of Arabica coffee gayo bean and leaf extract on blood sugar levels in healthy mice before and after the intervention of extract and fasting and postprandial blood glucose level after consumption of glucose.
 METHODS: This research is an experimental research study. The study used experimental animals which were divided into 8 groups which are the control group (Aquadest), group given Acarbose, the group given the Arabica coffee gayo bean extract with dosage of 50 mg, 100 mg and 200 mg in healthy mice, the group given the Arabica coffee gayo leaf extract with dosage of 30 mg, 60 mg and 120 mg in healthy mice.
 RESULTS: The results of the study obtained are before and after the intervention of extract showed the difference of p= 0.523 and after consumption of glucose the fasting and postprandial result showed the difference of p = 0.005.
 CONCLUSION: The use of Arabica coffee gayo bean and leaf extract showed a high decrease in blood glucose levels (BGL) compared to the control group.

Relationship between the Chemical Composition and the Biological Functions of Coffee

“…Epidemiological studies have shown that habitual coffee consumption may reduce the risk of Alzheimer's disease [68], and the coffee intake of male patients with primary Parkinson's disease is negatively correlated with the severity of tremor [69]. In the APP/PS2 transgenic mouse model of Alzheimer's disease in Figure 1, However, many reports have shown that many compounds in coffee can independently have neuroprotective effects, suggesting that decaffeinated coffee is also effective against neurodegenerative diseases.…”

The Effect of Coffee Arabica Gayo Leaf Extract (Coffea arabica L.) on Increased PI3K Serum Levels in Type 2 Diabetic Rat

“…Utilization of the coffee plant is currently still focused on seeds, while coffee leaves have not been widely used either as food products or as natural mixtures for food fortification, let alone medicine. Research by Martina (2019) shows that there is no significant difference between the benefits of coffee bean extract and coffee leaf extract in healthy rats on reducing blood sugar levels. Both provide the same effect of lowering blood sugar levels compared to placebo [3].…”

“…Research by Martina (2019) shows that there is no significant difference between the benefits of coffee bean extract and coffee leaf extract in healthy rats on reducing blood sugar levels. Both provide the same effect of lowering blood sugar levels compared to placebo [3]. In Sumatra, especially coffee leaves are served as a brewed drink called "Aia Kawa" which is believed to contain polyphenol, flavonoids, and caffeine that can prevent various diseases, one of which is carcinogenic disease [4].…”