The Difference in Estrogen Receptor Protein Level Between Breast Hypertrophy and Micromastia

Sun, Jiaming; Qiao, Qun; Qi, Kerning

doi:10.1097/01.prs.0000123634.16462.fd

Cited by 6 publications

(8 citation statements)

References 6 publications

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“…Sun et al . found a significant increase in oestrogen receptor expression in the mammary glands of breast hypertrophy patients compared with that in micromastia patients. Li et al .…”

Section: Discussionmentioning

confidence: 87%

“…Rapid growth of one or both breasts in a woman leads to significant physical and psychological difficulties that affect appearance and can also cause terrible suffering. This disease has been suspected to be associated with increased levels of oestrogen, progesterone or related enzymes in local tissue , but the mechanism of breast hypertrophy remains to be elucidated. Development of the mammary ducts is caused by extensive proliferation of epithelial cells, which ultimately form dendritic breast tissue in the fat pad .…”

Section: Introductionmentioning

confidence: 99%

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Stromal–epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary glands

Zhong

Wang

Yang

et al. 2014

J Cellular Molecular Medi

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True macromastia is a rare but disabling condition characterized by massive breast growth. The aetiology and pathogenic mechanisms for this disorder remain largely unexplored because of the lack of in vivo or in vitro models. Previous studies suggested that regulation of epithelial cell growth and development by oestrogen was dependent on paracrine growth factors from the stroma. In this study, a co-culture model containing epithelial and stromal cells was used to investigate the interactions of these cells in macromastia. Epithelial cell proliferation and branching morphogenesis were measured to assess the effect of macromastic stromal cells on epithelial cells. We analysed the cytokines secreted by stromal cells and identified molecules that were critical for effects on epithelial cells. Our results indicated a significant increase in cell proliferation and branching morphogenesis of macromastic and non-macromastic epithelial cells when co-cultured with macromastic stromal cells or in conditioned medium from macromastic stromal cells. Hepatocyte growth factor (HGF) is a key factor in epithelial–stromal interactions of macromastia-derived cell cultures. Blockade of HGF with neutralizing antibodies dramatically attenuated epithelial cell proliferation in conditioned medium from macromastic stromal cells. The epithelial–stromal cell co-culture model demonstrated reliability for studying interactions of mammary stromal and epithelial cells in macromastia. In this model, HGF secreted by macromastic stromal cells was found to play an important role in modifying the behaviour of co-cultured epithelial cells. This model allows further studies to investigate basic cellular and molecular mechanisms in tissue from patients with true breast hypertrophy.

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“…Sun et al . found a significant increase in oestrogen receptor expression in the mammary glands of breast hypertrophy patients compared with that in micromastia patients. Li et al .…”

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Stromal–epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary glands

Zhong

Wang

Yang

et al. 2014

J Cellular Molecular Medi

Self Cite

View full text Add to dashboard Cite

show abstract

“…Todavia, a maior parte dos estudos só avaliou 01 (um) tipo de receptor hormonal e não avalia outro, neste caso, receptor de estrógeno (ER) somente é analisado 30,58 , deixando a falha de não analisar progesterona e ainda em número baixo de pacientes ( 13), além de não avaliar os receptores com dados quantitativos de densidade ou potência de ligação ou frequência 58 . Das et al 59 perceberam ER+ e PR+ em 2 casos de gigantomastia e receptor de prolactina negativo.…”

Section: Hiperplasia Tecidualunclassified

“…Todavia, a maior parte dos estudos só avaliou 01 (um) tipo de receptor hormonal e não avalia outros, neste estudo, somente o receptor de estrógeno (ER) é analisado3 30,58 , analisaram um número baixo de pacientes (13) 58 .…”

Section: Hiperplasia Tecidualunclassified

“…Nesta tese e em diversos estudos, a análise mamária correta e padronizada da gigantomastia deve ser feita em mamas de mulheres adultas que apresentam níveis séricos normais de estrogênio e progesterona, com fatores de inclusão e exclusão adequados para não haver fatores de confusão ou doenças associadas que atrapalhem o correto diagnóstico de gigantomastia primária [28][29][30] .…”

Section: Introductionunclassified

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Análise de receptores hormonais de estrógeno e progesterona em hipertrofia mamária versus normomastia, avaliação de presença e densidade com uma nova proposta de classificação das hipertrofias mamárias

Teixeira¹

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Congenital Malformations and Developmental Changes of the Breast: A Dysmorphological View

Merlob¹

2018

Nipple-Areolar Complex Reconstruction

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The Difference in Estrogen Receptor Protein Level Between Breast Hypertrophy and Micromastia

Cited by 6 publications

References 6 publications

Stromal–epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary glands

Stromal–epithelial cell interactions and alteration of branching morphogenesis in macromastic mammary glands

Análise de receptores hormonais de estrógeno e progesterona em hipertrofia mamária versus normomastia, avaliação de presença e densidade com uma nova proposta de classificação das hipertrofias mamárias

Congenital Malformations and Developmental Changes of the Breast: A Dysmorphological View

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