The differences in T and B cell subsets in thyroid of children with Graves’ disease and Hashimoto’s thyroiditis

Beń‐Skowronek, Iwona; Szewczyk, Leszek; Kulik-Rechberger, Beata; Korobowicz, E

doi:10.1007/s12519-013-0398-0

Cited by 32 publications

(34 citation statements)

References 31 publications

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“…In their study Beń-Skowronek et al [ 16 ] found an increased number of plasma cells in HT. CD79 alpha+ B cells constituted almost half of the cells in the mononuclear lymphatic infiltrates; in HT, foci of destruction of thyroid follicles and thyrocytes were visible at the sites of accumulation of plasma cells.…”

Section: B Lymphocytesmentioning

confidence: 96%

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Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?

Pyzik

Grywalska

Matyjaszek‐Matuszek

et al. 2015

Journal of Immunology Research

233

171

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This review of literature attempts to identify the factors that are involved in the pathogenesis of Hashimoto thyroiditis, an immune defect in an individual with genetic susceptibility accompanied with environmental factors. The frequency of Hashimoto's disease is a growing trend and among Caucasians it is estimated at approximately 5%. The dysfunction of the gland may be clinically evident (0.1–2% of the population) or subclinical (10–15%). The pathology is diagnosed five to ten times more often in women than men and its incidence increases with the age (the peak of the number of cases is between 45 and 65); however, it can also be diagnosed in children. The pathogenesis of Hashimoto's thyroiditis is still not fully comprehended. In the etiology of Hashimoto thyroiditis excessively stimulated T CD4+ cells are known to play the most important role. Recent research has demonstrated an increasing role of newly discovered cells such as Th17 (CD4+IL-17+) or T regulatory cells (CD4+CD25+highFoxP3+) in the induction of autoimmune disorders. The process of programmed cell death also plays an equally important role in the pathogenesis and the development of hypothyroidism.

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Section: B Lymphocytesmentioning

confidence: 96%

“…Observations under a light microscope revealed that T suppressor/cytotoxic cells were accumulated at the sites of destruction of thyroid follicles. These sites were surrounded by connective tissue fibers and fibroblasts [ 16 ].…”

Section: T Lymphocytesmentioning

confidence: 99%

Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?

Pyzik

Grywalska

Matyjaszek‐Matuszek

et al. 2015

Journal of Immunology Research

233

171

View full text Add to dashboard Cite

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“…Actually, the pathogenic factors in Graves' hyperthyroidism are the autoaggressive CD4 + cells which drive the maturation of the plasma cells and secretion of stimulatory autoantibody targeting thyrotrophin (TSH) receptor (i.e., TR-Ab). In hypothyroid HT, however, the downregulated or even inverted CD4/CD8 ratio results from increased frequency of CD8 + cells, whose infiltration and cytolytic effects could be directly responsible for the destruction of the follicular thyroid and thyrocytes [ 23 ]. Thus, the divergence of T cell polarization may exactly explain for the main reason for the completely opposite clinical manifestations in GD and HT.…”

Section: Discussionmentioning

confidence: 99%

“…HT, also referred to as chronic lymphocytic thyroiditis, is an autoimmune disease in which the thyroid gland is attacked by a variety of cell- and antibody-mediated immune processes [ 32 ]. A decrease in the CD4/CD8 ratio in HT hypothyroid patients was observed [ 23 ], in contrast to an increase in the ratio in autoimmune hyperthyroid patients. This suggests a different role for T lymphocytes in the pathogenesis of the two major human autoimmune thyroid diseases [ 22 , 23 ].…”

Section: Discussionmentioning

confidence: 99%

Dual‐Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases

Zhao

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Purpose. To investigate the effects of Corbrin Capsule (CS-C-Q80), a drug derived from Cordyceps sinensis (Berk.) Sacc., on autoimmune thyroid diseases (AITD). Methods. 44 Patients with Graves's disease (GD) and 56 patients with Hashimoto's thyroiditis (HT) were randomly assigned to treatment group (GD-Tx and HT-Tx) or control group (GD-Ct and HT-Ct). The control groups were given methimazole or levothyroxine only while the treatment groups were given Corbrin Capsule (2.0 g tid) besides the same conventional prescriptions as control groups. Thyroid hormones, thyroid antibodies, and T lymphocyte subsets were quantified at baseline and 24 weeks posttreatment. Results. Significant drop of serum anti-TPO-Ab levels was observed in both GD-Tx and HT-Tx groups. Before treatment, GD patients had higher helper T cells compared to cytotoxic T cells, while HT patients suffered from a nearly inverted proportion of helper T/cytotoxic T cells. There was a significant drop of the helper T/cytotoxic T cells ratio in GD-Tx to the median of the normal ranges after Corbrin treatment for 24 weeks, while that in HT-Tx was elevated. Conclusion. Corbrin Capsule could restore the balance between helper T and cytotoxic T cells in both GD and HT patients with dual-directional immunomodulatory effects. And it could significantly reduce the autoantibody levels in both GD and HT.

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“…The antithyroid inflammatory reaction in HT is enhanced by several mechanisms, counting on the participation of autoreactive CD4 + T cells, CD8 + cytotoxic T cells and anti-thyroid antibodies producing-B cells. An influx of the lymphoid cells, dendritic cells and macrophages into thyroid occurs as a consequence of inflammatory events (Antonelli A, 2015;Ben-Skowronek, 2013). The disease is a result of a Th1 immune response which triggers cell mediated immunity and thyroid follicular cell death by apoptosis.…”

Section: Pathogenic Mechanismsmentioning

confidence: 99%

Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction

Neto¹

2018

Rev. Cient. Fac. Med Campos

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Hashimoto’s thyroiditis (HT) is an autoimmune and inflammatory disease in which antibodies are directed against the thyroid gland leading to chronic inflammation and hypothyroidism. The autoimmunity against thyroid antigens can be associated to genetic background and environmental factors. Thyroid peroxidase (TPO) and thyroglobulin (TG) are the major autoantigens for characterizing the disease. And the pathogenic mechanism is related to the activation of autoreactive CD4+ T cells, CD8+ cytotoxic T cells and antithyroid antibody producing-B cells. The treatment for hypothyroidism is based on thyroid hormone replacement, the levothyroxine. This review briefly discusses the clinical and pathogenic profile of HT and the importance of a correct diagnostics.

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The differences in T and B cell subsets in thyroid of children with Graves’ disease and Hashimoto’s thyroiditis

Abstract: Graves' disease is characterized by the increased number of CD4+ T cells and CD8+ T cells. Hashimoto's thyroiditis is characterized by the low number of CD4+ T cells and increased number of CD8+ T cells. CD8+ T cells have cytotoxic properties only in Hashimoto's thyroiditis.

Cited by 32 publications

References 31 publications

Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?

Immune Disorders in Hashimoto’s Thyroiditis: What Do We Know So Far?

Dual‐Directional Immunomodulatory Effects of Corbrin Capsule on Autoimmune Thyroid Diseases

Current Concepts in Endocrinology for Clinicians and Medical Students. Hashimoto’s Thyroiditis: clinical and subclinical thyroid dysfunction

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