The different concentrations of mast cells in the musculature of the esophagus and the colon

Pinheiro, Simone Wanderley; Micheletti, Adilha Misson Rua; Crema, Virgínia Oliveira; Côbo, Eliângela de Castro; Silva, Ana Cristina Araújo Lemos da; Adad, Sheila Jorge

doi:10.1016/j.humpath.2008.02.002

Cited by 1 publication

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“…In some way they could have some relationship with the higher frequency of parasitism in the esophagus to the colon. On the other hand, we might also remember that there are structural differences between the esophagus and colon: (1) there is usually greater amount of mast cells in the esophagus than in the colon, which could favor the intensification of inflammation in the esophagus [ 22 ]; (2) the presence of blood vessels in the ganglia of the myenteric plexus of the esophagus, which is not seen in the colon, could encourage primary inflammation in its ganglia [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Research onTrypanosoma cruziand Analysis of Inflammatory Infiltrate in Esophagus and Colon from Chronic Chagasic Patients with and without Mega

Côbo

Silveira

Micheletti

et al. 2012

Journal of Tropical Medicine

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To compare parasitism and inflammatory process in esophagus and colon from chronic chagasic patients, immunohistochemistry was carried out to research for T. cruzi and to evaluate the inflammatory infiltrate in the muscular and myenteric plexus in 39 esophagi (20 with and 19 without megaesophagus) and 50 colons (25 with and 25 without megacolon). The frequency of T. cruzi in megaesophagus was 20%, and in megacolon it was 4%. No amastigotes were found in organs without mega; considering the total of esophagi (with and without mega), the frequency of T. cruzi would be 10% and 2% in the colon. Myositis and ganglionitis were more frequent and intense in organs with mega compared to those without mega, and in esophagus compared to colon. Qualitatively, inflammatory infiltration in esophagus and colon, with or without mega, was similar, consisting predominantly of T lymphocytes (CD3+), scarce macrophages (CD68+), and rare B lymphocytes (CD20+).

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Section: Discussionmentioning

confidence: 99%