The different faces of mycosis fungoides: results of a single‐center study

Abstract

Background Mycosis fungoides (MF) accounts for the majority of cutaneous lymphomas.Apart from the predominant Alibert-Bazin type, several clinicopathological variants of diverse prevalence and biological behavior have been described. Data on clinical and epidemiological aspects of MF clinical subtypes are still weak.Aim To outline the clinical and epidemiological profile of the different MF types in a large volume of Greek patients.Methods Retrospective analysis of 688 MF cases treated in our lymphoma clinic. Epidemiological, clinical, pathological, and immunohistochemical data were retrieved.Results Six-hundred and thirty-six patients (416 males, 220 females) were included. The mean age at diagnosis was 60.2 years; the mean duration of disease prior to diagnosis was 63.2 months. Early-stage MF (I-IIA) involved 475 cases (74.7%). The prevalent type was classical MF (68.5%), followed by folliculotropic (17%), poikilodermic (5.5%), and psoriasiform (4.7%) MF. Atypical MF lesions as the sole manifestation of folliculotropic mycosis fungoides (FMF)alopecia areata-like lesions (n = 10), keratosis pilaris-like lesions (n = 9) or acneiform rash (n = 4)were also observed. Both poikilodermic and folliculotropic subtypes mainly involved younger patients. A significant diagnostic latency concerning poikilodermic and psoriasiform MF cases was recorded. Only 23 (3.3%) cases were of juvenile onset, with classical and poikilodermic MF equally affecting this age group, closely followed by FMF.Conclusions Our study presents the whole clinical-epidemiological spectrum of MF in a large Greek cohort. The high prevalence of atypical MF manifestations characterized by early onset and indolent clinical course stood out among our FMF sample.MF patients followed at the Cutaneous Lymphoma Outpatient

Immunohistochemical research of CADM 1 in mycosis fungoides

“…In the current research, the incidence of mycosis fungoides (MF) was higher in males (60%) (40%) with a male to female ratio equals 3:2 which was matching with Sidiropoulou et al, 2020 [9] , Ocampo et al, 2020 [10] , Amorim et al, 2018 [11] and Boulos et al, 2014 [12] , they had demonstrated that the incidence of MF was higher in males.…”

Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma

“…Thus, a better understanding of factors driving cancer cell progression is urgently needed. However, disease heterogeneity of MF, both on clinical and molecular levels, is a major challenge in this regard [12][13][14][15]. In this study, we profiled patches with longstanding history, and compared them with recently developed plaques or tumors within the same patient to overcome inter-individual variability.…”

A Comprehensive Update of the Atypical, Rare and Mimicking Presentations of Mycosis Fungoides

“…Atypical and rare variants [45] include the folliculotropic MF (FMF)/syringotropic forms [24,78,126,127] accounting for about 10-15% of the total MF cases, the chalazoderma-type MF, also termed granulomatous slack skin [76], pagetoid reticulosis, ichthyosiform MF [87], blastic MF, granulomatous MF [60,128], hypopigmented MF, useful considered as a surrogate marker of cytotoxic immunity targeting the malignant T cells and papillomatous MF, verrucous MF [104], poikilodermic MF [100-102, 132], and invisible MF where pruritus is the only clinical sign [24,93,118]. All these aforementioned clinical subtypes of MF may imitate a large array of other dermatological manifestations [6, 26,27,31,[133][134][135], again hindering prompt diagnosis. This fact has already been described [133], relating that MF can mimic more than 50 different clinical entities.…”

“…Since the last significant overviews dealing with the various clinical manifestations of MF are already some years of age [23][24][25][26][27], a review of existing data was performed as well as a literature update.…”