2024
DOI: 10.1101/2024.09.04.24313061
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The differential effects of common and rare genetic variants on cognitive performance across development

Daniel S. Malawsky,
Mahmoud Koko,
Petr Danacek
et al.

Abstract: Common and rare genetic variants that impact adult cognitive performance also predispose to rare neurodevelopmental conditions involving cognitive deficits in children. However, their influence on cognition across early life remains poorly understood. Here, we investigate the contribution of common genome-wide and rare exonic variation to cognitive performance across childhood and adolescence primarily using the Avon Longitudinal Study of Parents and Children (n=6,495 unrelated children). We show that the effe… Show more

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