The Differential Tissue Expression of Inflammatory, Oxidative Stress, and Apoptosis Markers in Human Uncontrolled Non-Heart-Beating Donors

Núñez-Peña, J.R.; García-Martín, María C.; Ishishi, Yoko Lucía Olmedilla; Martín-Antona, Esteban; Berthuin, Jeremy; Rancán, Lisa; Vara, E.; Balibrea, J.L.

doi:10.1097/tp.0b013e31828ee151

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…The accumulation of acute and chronic injuries in the donor leads to increased senescence and reduced organ quality. In ECD donors, this may be due to an increase in age-related oxidative damage ( Figure 2 ) [ 16 ] as well as a reduction of autophagic activity and hence the inability to remove oxidatively damaged organelles. This link was shown in the kidneys of aged rats, where a high caloric diet exacerbated oxidative damage and aging, while autophagy was reduced [ 79 ].…”

Section: Autophagy and Oxidative Stress In Transplantationmentioning

confidence: 99%

“…Oxidative stress levels correlate with graft survival in all steps of the transplantation process including in the donor [ 6 – 16 ], during preservation [ 17 , 18 ], and reperfusion in the recipient. In donation after brain death (DBD) donors, brain death pathophysiology leads to increased renal oxidative damage markers which correlate with acute rejection, delayed graft function (DGF), and allograft function [ 6 – 16 ]. In donation after cardiac death (DCD) donors, cardiac arrest causes warm ischemia which is associated with impaired graft function and higher mortality rates [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

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The Crosstalk between ROS and Autophagy in the Field of Transplantation Medicine

Erp

Hoeksma

Rebolledo

et al. 2017

Oxidative Medicine and Cellular Longevity

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Many factors during the transplantation process influence posttransplant graft function and survival, including donor type and age, graft preservation methods (cold storage, machine perfusion), and ischemia-reperfusion injury. Successively, they will lead to cellular and molecular alterations that determine cell and ultimately organ fate. Oxidative stress and autophagy are implicated in posttransplant outcome since they are both affected by the stress responses triggered in each step (donor, preservation, and recipient) of the transplantation process. Furthermore, oxidative stress influences autophagy and vice versa. Interestingly, both processes have positive as well as negative effects on graft outcome, suggesting they are tightly linked during the transplantation process. In this review, we discuss the importance, regulation and crosstalk of oxidative signals, and autophagy in the field of transplantation medicine.

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Section: Autophagy and Oxidative Stress In Transplantationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Crosstalk between ROS and Autophagy in the Field of Transplantation Medicine

Erp

Hoeksma

Rebolledo

et al. 2017

Oxidative Medicine and Cellular Longevity

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“…However, the inevitable occurrence of WIP can activate the immune system in donors and aggravate I/R injury, which increases the risk of PGD. 10 In a rat model of LTx, we showed that 3% hydrogen gas ventilation during WIP improved post-transplantation lung function, as determined by improved partial pressure of arterial oxygen (PaO 2 )/fraction of inspired oxygen (FiO 2 ) ratio and static compliance of the lung grafts. Hydrogen preconditioning alleviated cardiac death lung graft I/R injury by reducing inflammatory mediator upregulation, demonstrated by decreased myeloperoxidase (MPO) activity, lower serum interleukin (IL)-6 and tumor necrosis factor (TNF)-a levels, and elevated IL-10 level.…”

Section: The Protective Effect Of Hydrogen On Donor Lung Injurymentioning

confidence: 97%

Protective effects of molecular hydrogen on lung injury from lung transplantation

Quan

Zheng

Zhou

2021

Exp Biol Med (Maywood)

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Lung grafts may experience multiple injuries during lung transplantation, such as warm ischaemia, cold ischaemia, and reperfusion injury. These injuries all contribute to primary graft dysfunction, which is a major cause of morbidity and mortality after lung transplantation. As a potential selective antioxidant, hydrogen molecule (H2) protects against post-transplant complications in animal models of multiple organ transplantation. Herein, the authors review the current literature regarding the effects of H2 on lung injury from lung transplantation. The reviewed studies showed that H2 improved the outcomes of lung transplantation by decreasing oxidative stress and inflammation at the donor and recipient phases. H2 is primarily administered via inhalation, drinking hydrogen-rich water, hydrogen-rich saline injection, or a hydrogen-rich water bath. H2 favorably modulates signal transduction and gene expression, resulting in the suppression of pro-inflammatory cytokines and excess reactive oxygen species production. Although H2 appears to be a physiological regulatory molecule with antioxidant, anti-inflammatory and anti-apoptotic properties, its exact mechanisms of action remain elusive. Taken together, accumulating experimental evidence indicates that H2 can significantly alleviate transplantation-related lung injury, mainly via inhibition of inflammatory cytokine secretion and reduction in oxidative stress through several underlying mechanisms. Further animal experiments and preliminary human clinical trials will lay the foundation for the use of H2 as a treatment in the clinic.

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“…Uncontrolled DCD procedures involve extended periods of warm ischemia, intentionally amplifying cellular damage through inflammatory responses, oxidative stress, and apoptotic processes [28].…”

Section: Warm Ischemia Injury In Donation After Cardiac Deathmentioning

confidence: 99%

Focusing on Ischemic Reperfusion Injury in the New Era of Dynamic Machine Perfusion in Liver Transplantation

Chullo,

Panisello-Rosello,

Marquez

et al. 2024

IJMS

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Liver transplantation is the most effective treatment for end-stage liver disease. Transplant indications have been progressively increasing, with a huge discrepancy between the supply and demand of optimal organs. In this context, the use of extended criteria donor grafts has gained importance, even though these grafts are more susceptible to ischemic reperfusion injury (IRI). Hepatic IRI is an inherent and inevitable consequence of all liver transplants; it involves ischemia-mediated cellular damage exacerbated upon reperfusion and its severity directly affects graft function and post-transplant complications. Strategies for organ preservation have been constantly improving since they first emerged. The current gold standard for preservation is perfusion solutions and static cold storage. However, novel approaches that allow extended preservation times, organ evaluation, and their treatment, which could increase the number of viable organs for transplantation, are currently under investigation. This review discusses the mechanisms associated with IRI, describes existing strategies for liver preservation, and emphasizes novel developments and challenges for effective organ preservation and optimization.

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The Differential Tissue Expression of Inflammatory, Oxidative Stress, and Apoptosis Markers in Human Uncontrolled Non-Heart-Beating Donors

Abstract: The initial tissue damage generated during the UNHB donation process is at least comparable with that observed in BDD. However, although the expression of the immediate immune response and apoptosis markers is similar, a mild impairment of the local antioxidant activity was observed.

Cited by 5 publications

References 42 publications

The Crosstalk between ROS and Autophagy in the Field of Transplantation Medicine

The Crosstalk between ROS and Autophagy in the Field of Transplantation Medicine

Protective effects of molecular hydrogen on lung injury from lung transplantation

Focusing on Ischemic Reperfusion Injury in the New Era of Dynamic Machine Perfusion in Liver Transplantation

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