The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T Cells

Wang, Yifei; Qin, Tian; Ye, Lilin

doi:10.3389/fcimb.2022.953022

Cited by 7 publications

(9 citation statements)

References 195 publications

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“…Additionally, ZC3HAV1 is an antiviral protein activated by interferons that can limit SARS-CoV-2 replication 27,28 . Furthermore, the involvement of CUL3 in regulating T follicular helper (TFH) cell differentiation 29 , was recently identified in the context of SARS-CoV-2 30 , suggests a mechanism for long-term protective immunity, indicative of vaccination success. While our study was not designed to elucidate the specific molecular mechanisms of their regulation, the fact that we consistently observe the regulation of these low-abundant immunity- and inflammation-related proteins is intriguing and suggests further exploration.…”

Section: Resultsmentioning

confidence: 99%

Deep, unbiased and quantitative mass spectrometry-based plasma proteome analysis of individual responses to mRNA COVID-19 vaccine

Huang,

Campos,

Wang

et al. 2024

Preprint

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Global campaign against COVID-19 have vaccinated a significant portion of the world population in recent years. Combating the COVID-19 pandemic with mRNA vaccines played a pivotal role in the global immunization effort. However, individual responses to a vaccine are diverse and lead to varying vaccination efficacy. Despite significant progress, a complete understanding of the molecular mechanisms driving the individual immune response to the COVID-19 vaccine remains elusive. To address this gap, we combined a novel nanoparticle-based proteomic workflow with tandem mass tag (TMT) labeling, to quantitatively assess the proteomic changes in a cohort of 12 volunteers following two doses of the Pfizer-BioNTech mRNA COVID-19 vaccine. This optimized protocol seamlessly integrates comprehensive proteome analysis with enhanced throughput by leveraging the enrichment of low-abundant plasma proteins by engineered nanoparticles. Our data demonstrate the ability of this nanoparticle-based workflow to quantify over 3,000 proteins from 48 human plasma samples, providing the deepest view into COVID-19 vaccine-related plasma proteome study. We identified 69 proteins exhibiting a boosted response to the vaccine after the second dose. Additionally, 74 proteins were differentially regulated between seven volunteers, who contracted COVID-19 despite receiving two doses of the vaccine, and the ones who did not contract COVID-19. These findings offer valuable insights into individual variability in response to vaccination, demonstrating the potential of personalized medicine approaches in vaccine development.

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Section: Resultsmentioning

confidence: 99%

Deep, unbiased and quantitative mass spectrometry-based plasma proteome analysis of individual responses to mRNA COVID-19 vaccine

Huang,

Campos,

Wang

et al. 2024

Preprint

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show abstract

“…T cells, including helper T cell, cytotoxic T cells, and regulatory T cell, among which helper T cells can secrete a variety of cytokines, such as IFN-γ, IL-10, etc. to sensitize specific immune responses ( 40 ). In the present study, CSFV vaccine immunization significantly inhibited NK cell activity and promoted the secretion of IFN-γ and IL-10, while PTFP markedly enhanced NK cell activity and further facilitated IFN-γ and IL-10 secretion.…”

Section: Discussionmentioning

confidence: 99%

Structural characterization and adjuvant action of Paulownia tomentosa flower polysaccharide on the immune responses to classical swine fever vaccine in mice

Chen,

Yu,

Zheng

et al. 2023

Front. Vet. Sci.

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Paulownia tomentosa flower polysaccharide (PTFP) from dried cultured P. tomentosa flowers, is widely known for its immunomodulatory activities. Here, PTFP was extracted from Paulownia tomentosa flower using hot water extraction, followed by ethanol precipitation methods. Structural characterization of PTFP was revealed by scanning electron microscope, high-performance anion-exchange chromatography, gel chromatography, ultraviolet and infrared spectral. Meanwhile, adjuvant action of PTFT on the immune responses to classical swine fever vaccine in mice was evaluated to further proclaim the immune regulatory effect of PTFP. The results showed that PTFP was a type of heteropolysaccharide with a dense, rough surface and high molecular weight (667.02 kDa), mainly composed of glucose (30.93%), rhamnose (29.99%), galactose (15.66%), arabinose (6.95%), mannose (5.52%), and xylose (4.80%). The results of gel chromatography suggested that the molecular configuration of PTFP may be a spherical structure. The infrared spectrum results confirmed that the functional groups and chemical bond of PTFP contained -OH, O-H, C-H, C=O, C-O, etc. Moreover, PTFP exhibited obvious immune enhancement effect by improving concanavalin A (ConA), lipopolysaccharide (LPS), and CSFV E2-stimulated splenocyte growth and natural killer cell activity in CSFV-immunized mice. Similarly, the titers of CSFV E2-specific IgG, IgG1, IgG2a, and IgG2b antibodies and IFN-γ and IL-10 levels in CSFV-immunized mice were distinctly increased by PTFP treatment. Overall, PTFP was a macromolecular heteropolysaccharide primarily containing glucose and rhamnose, and possessed the auxiliary effect of immune enhancement on the immune responses to classical swine fever vaccine.

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“…Strong T-cell responses are associated with milder COVID-19, and they also contribute to the protective response produced by vaccination ( 103 , 104 ). Studying SARS-CoV-2-specific T-cell responses could contribute to speeding up the vaccine testing process and facilitate vaccine development in the context of the COVID-19 pandemic ( 113 ). However, many unknowns remain, such as whether rapid induction of adaptive immune responses to SARS-CoV-2 and less severe COVID-19 manifestations are driven by pre-existing T cells ( 114 ), and whether a role for vaccine-elicited memory CD4 + T cell and CD8 + T cell responses in directly mediating protection from SARS-CoV-2 infection is unclear ( 115 ).…”

Section: Discussionmentioning

confidence: 99%

Uncovering the information immunology journals transmitted for COVID-19: A bibliometric and visualization analysis

et al. 2022

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BackgroundSince the global epidemic of the coronavirus disease 2019 (COVID-19), a large number of immunological studies related to COVID-19 have been published in various immunology journals. However, the results from these studies were discrete, and no study summarized the important immunological information about COVID-19 released by these immunology journals. This study aimed to comprehensively summarize the knowledge structure and research hotspots of COVID-19 published in major immunology journals through bibliometrics.MethodsPublications on COVID-19 in major immunology journals were obtained from the Web of Science Core Collection. CiteSpace, VOSviewer, and R-bibliometrix were comprehensively used for bibliometric and visual analysis.Results1,331 and 5,000 publications of 10 journals with high impact factors and 10 journals with the most papers were included, respectively. The USA, China, England, and Italy made the most significant contributions to these papers. University College London, National Institute of Allergy and Infectious Diseases, Harvard Medical School, University California San Diego, and University of Pennsylvania played a central role in international cooperation in the immunology research field of COVID-19. Yuen Kwok Yung was the most important author in terms of the number of publications and citations, and the H-index. CLINICAL INFECTIOUS DISEASES and FRONTIERS IN IMMUNOLOGY were the most essential immunology journals. These immunology journals mostly focused on the following topics: “Delta/Omicron variants”, “cytokine storm”, “neutralization/neutralizing antibody”, “T cell”, “BNT162b2”, “mRNA vaccine”, “vaccine effectiveness/safety”, and “long COVID”.ConclusionThis study systematically uncovered a holistic picture of the current research on COVID-19 published in major immunology journals from the perspective of bibliometrics, which will provide a reference for future research in this field.

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The Differentiation and Maintenance of SARS-CoV-2-Specific Follicular Helper T Cells

Cited by 7 publications

References 195 publications

Deep, unbiased and quantitative mass spectrometry-based plasma proteome analysis of individual responses to mRNA COVID-19 vaccine

Deep, unbiased and quantitative mass spectrometry-based plasma proteome analysis of individual responses to mRNA COVID-19 vaccine

Structural characterization and adjuvant action of Paulownia tomentosa flower polysaccharide on the immune responses to classical swine fever vaccine in mice

Uncovering the information immunology journals transmitted for COVID-19: A bibliometric and visualization analysis

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