The differentiation of organic and “innocent” systolic murmurs

Humphries, J.O'Neal; McKusick, Victor A.

doi:10.1016/s0033-0620(62)80027-9

Cited by 80 publications

(8 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Humphries and McKusick 4 first described inferior TWIs in a patient with a late systolic murmur, a condition that was later described as MVP. Since then, inferior TWIs have been recognized to be associated with MVP, 5 and recently they were found to be associated with a higher risk of SCD in patients with MVP.…”

Section: Discussionmentioning

confidence: 99%

Mitral valve repair results in suppression of ventricular arrhythmias and normalization of repolarization abnormalities in mitral valve prolapse

Alqarawi

Birnie

Burwash

2018

HeartRhythm Case Reports

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Mitral valve repair results in suppression of ventricular arrhythmias and normalization of repolarization abnormalities in mitral valve prolapse

Alqarawi

Birnie

Burwash

2018

HeartRhythm Case Reports

View full text Add to dashboard Cite

“…This course, now named the McKusick Short Course, will be held for the 62nd year in 2021. During the early 1960s, he occasionally published on topics related to internal medicine (e.g., epidemiologic investigations of sarcoidosis) and cardiology (e.g., how to determine if a systolic murmur is “innocent”) (Buck & McKusick, 1961; Humphries & McKusick, 1962), but most publications at this time focused on genetics. He published several articles on X‐linked conditions including colorblindness (OMIM# 303800), glucose‐6‐phosphate dehydrogenase deficiency (OMIM# 305900), and an X‐linked form of spastic paraplegia (OMIM# 312920) (Johnston & McKusick, 1962; Porter et al, 1962).…”

Section: –1964 (45 Papers)mentioning

confidence: 99%

Viewing VictorMcKusick's legacy through the lens of his bibliography

Rasmussen

Pomputius

Amberger

et al. 2021

American J of Med Genetics Pt A

View full text Add to dashboard Cite

Victor McKusick's contributions to the field of medical genetics are legendary and include his contributions as a mentor, as creator of Mendelian Inheritance in Man (now Online Mendelian Inheritance in Man [OMIM®]), and as a leader in the field of medical genetics. McKusick's full bibliography includes 772 publications. Here we review the 453 papers authored by McKusick and indexed in PubMed, from his earliest paper published in the New England Journal of Medicine in 1949 to his last paper published in American Journal of Medical Genetics Part A in 2008. This review of his bibliography chronicles McKusick's evolution from an internist and cardiologist with an interest in genetics to an esteemed leader in the growing field of medical genetics. Review of his bibliography also provides a historical perspective of the development of the discipline of medical genetics. This field came into its own during his lifetime, transitioning from the study of interesting cases and families used to codify basic medical genetics principles to an accredited medical specialty that is expected to transform healthcare. Along the way, he helped to unite the fields of medical and human genetics to focus on mapping the human genome, culminating in completion of the Human Genome Project. This review confirms the critical role played by Victor McKusick as the founding father of medical genetics.

show abstract

“…It is commonly heard just inside the apex or at the left parasternal edge, but may be heard over the whole precordium. It characteristically becomes softer or disappears on standing and reappears on squatting (Rhodes 1955;Humphries & McKusick 1962;McLaren et al 1980). The innocent pulmonary ejection systolic murmur is high pitched and said to have a blowing quality.…”

Section: Classification and Characteristics Of The Innocent Murmurmentioning

confidence: 99%

“…It is loudest at the second left interspace, but may also be heard at the apex, left sternal border, aortic area and in the neck (Harris 1955;Humphries & McKusick 1962;Barlow & Pocock 1965). The second heart sound must be split normally, i.e.…”

Section: Classification and Characteristics Of The Innocent Murmurmentioning

confidence: 99%