The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review

Ghrénassia, Étienne; Martis, N.; Boyer, Julien; Burel‐Vandenbos, Fanny; Mékinian, A.; Coppo, Paul

doi:10.1016/j.jaut.2015.01.010

Cited by 57 publications

(41 citation statements)

References 50 publications

(99 reference statements)

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“…Since the common etiology of these diseases is lymphocytic infiltration, a syndrome referred to as diffuse infiltrative lymphocytosis syndrome (DILS) has been proposed to describe the systemic dysfunction of multiple glands as a result of HIV infection. DILS is defined as an HIV-associated disease that causes destruction of glands, namely the salivary and lacrimal exocrine glands, due to glandular CD8 + T cell infiltration in the setting of reduced CD4 + counts [ 71 , 72 , 73 , 109 , 110 , 111 , 112 ]. Some studies have suggested that DILS affects 3–7.8% of HIV-infected patients [ 72 , 111 ].…”

Section: Diffuse Infiltrative Lymphocytosis Syndrome: Definition Amentioning

confidence: 99%

“…Some studies have suggested that DILS affects 3–7.8% of HIV-infected patients [ 72 , 111 ]. Worldwide, its prevalence is reportedly highest in Africa, while in the United States, DILS is most prevalent in African Americans [ 109 , 112 ].…”

Section: Diffuse Infiltrative Lymphocytosis Syndrome: Definition Amentioning

confidence: 99%

“…Clinical manifestations of DILS consist of bilateral parotiditis (with parotid enlargement and lymphadenopathy) and sicca symptoms, such as xerostomia and xerophthalmia. DILS may be further accompanied by a range of extra-glandular organ involvement [ 109 , 112 ]. Lymphocytic interstitial pneumonia can present with a dry cough and progressive exertional dyspnea [ 119 , 120 , 121 ].…”

Section: Diffuse Infiltrative Lymphocytosis Syndrome: Definition Amentioning

confidence: 99%

See 2 more Smart Citations

Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands

Nizamuddin

Koulen

McArthur

2018

IJMS

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The structure and function of exocrine glands are negatively affected by human immunodeficiency virus (HIV) infection and its co-morbidities, including innate and adaptive immune responses. At the same time, exocrine function may also be influenced by pharmacotherapies directed at the infectious agents. Here, we briefly review the role of the salivary glands and lacrimal glands in normal physiology and exocrine pathogenesis within the context of HIV infection and acquired immune deficiency syndrome (AIDS), including the contribution of antiretroviral therapies on both. Subsequently, we discuss the impact of HIV infection and the types of antiretroviral therapy on disease management and therapy development efforts.

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Section: Diffuse Infiltrative Lymphocytosis Syndrome: Definition Amentioning

confidence: 99%

Section: Diffuse Infiltrative Lymphocytosis Syndrome: Definition Amentioning

confidence: 99%

Section: Diffuse Infiltrative Lymphocytosis Syndrome: Definition Amentioning

confidence: 99%

See 1 more Smart Citation

Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands

Nizamuddin

Koulen

McArthur

2018

IJMS

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“…Nerve biopsy or parotid gland needle biopsy reveals polyclonal CD8þ T cell infiltrates in the endoneurium and epineurium. 29 The neuropathy responds briskly to cART if HIV is untreated and to corticosteroids, with stabilization or recovery. 30…”

Section: Diffuse Infiltrative Lymphocytosis Syndromementioning

confidence: 99%

Peripheral Neuropathies in Infectious Diseases

et al. 2019

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Peripheral nerve disorders may be the presenting manifestation of a systemic infection, and early recognition of these syndromes is essential for prompt diagnosis and treatment. Mechanisms associated with infectious disorders of the peripheral nerve are often complex and multiple, with secondary inflammation, direct infectious invasion of nerves, and toxicities of antimicrobial medications playing a role. Here, we provide a complete review of the most common infectious pathogens that can affect the peripheral nerves.

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“…Puede tener manifestaciones extra glandulares también. A diferencia del Sjogren no tiene serología positiva para ANA y demás anticuerpos y en la biopsia la infiltración de linfocitos es CD8 siendo en Sjogren CD4 (4,5). Este diagnóstico queda excluido en nuestra paciente por tener serología negativa para VIH.…”

Section: Síndrome De Infiltración Difusa De Linfocitos (Dils)unclassified

Caso clínico 01-2017. Mujer de 20 años con crecimiento de glándulas salivares y lacrimales, adenopatías, fiebre y lesión pulmonar

Vásquez¹,

Mejía²,

Rodriguez³

et al. 2017

Rev Med Hered

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Mujer de 20 años, natural de Iquitos y procedente de Lima quien hace 4 semanas presentó aumento de volumen en el borde inferior del párpado superior izquierdo y una semana después del párpado superior derecho. Dos semanas antes del ingreso se agregó crecimiento parotídeo bilateral y en región submaxilar y una semana antes de la admisión se añadió otalgia bilateral, disfonía y xerostomía. Durante esa semana también notó aparición de un ganglio axilar derecho, no doloroso, sensación de alza térmica y tos no productiva por lo cual acudió al hospital, siendo hospitalizada. En las funciones biológicas tenía hiporexia, sed aumentada, sudoración normal y refería una pérdida de peso de 4 kg en el último mes. Las deposiciones y orina no mostraban alteraciones y estaba eutímica.La paciente vivía en Lima hace varios años y era estudiante de administración. No ingería alcohol no fumaba ni usaba drogas. Su historia ginecológica era G: 0 P: 0, régimen catamenial 5/30, negaba relaciones sexuales y su FUR fue dos semanas antes del ingreso.No tenía antecedentes patológicos de importancia y previamente había estado sana. No había tenido intervenciones quirúrgicas. No tenía alergias a medicamentos. No tenía hermanos y sus padres no sufrían de enfermedades. En la revisión anamnésica de sistemas y aparatos negaba xeroftalmia, alopecia, artralgias o lesiones dérmicas.Al examen físico la PA: 100/60 mmHg FC: 78 x' FR: 18 x' T: 36,4°C; SAT: 97%; FiO 2 : 21%; peso: 54 kg; talla: 157 cm; IMC: 22,4. Lucía crónicamente enferma en regular estado general, hidratada, lúcida y orientada en las tres esferas, llamó la atención su fascies (Figura 1). La piel, tejido celular subcutáneo y sistema osteomioarticular no mostraban alteraciones significativas. Se palpaba ganglio axilar derecho de 2 cm, no doloroso, móvil. Al examen regional se evidenció crecimiento de glándulas lacrimales, parótidas y glándula salivar submaxilar; el resto del cuello y las mamas, sin alteraciones. En tórax el murmullo vesicular pasaba bien en ambos campos pulmonares y no se auscultaron rales. En el examen cardiovascular, los ruidos cardiacos eran rítmicos, no habían soplos y los pulsos estaban conservados; no había ingurgitación yugular. El abdomen era plano, los ruidos hidroaéreos estaban presentes, y no se palpaban masas ni vísceromegalia. Al examen neurológico las

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The diffuse infiltrative lymphocytosis syndrome (DILS). A comprehensive review

Cited by 57 publications

References 50 publications

Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands

Contribution of HIV Infection, AIDS, and Antiretroviral Therapy to Exocrine Pathogenesis in Salivary and Lacrimal Glands

Peripheral Neuropathies in Infectious Diseases

Caso clínico 01-2017. Mujer de 20 años con crecimiento de glándulas salivares y lacrimales, adenopatías, fiebre y lesión pulmonar

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