Generative artificial intelligence (Gen-AI) tools are increasingly utilized in educational settings for tasks ranging from content creation to personalizing learning experiences. While these tools offer considerable potential to transform education, their integration brings challenges, including biases, dependency, and ethical dilemmas. Addressing these challenges and ethical concerns is essential to fully leveraging Gen-AI to promote equitable and effective learning. This chapter presents a framework for the responsible use of Gen-AI tools in learning environments, offering guidance to educators, technologists, policymakers, students, and other stakeholders. The framework provides proactive guidelines to navigate the complexities of Gen-AI, ensuring these tools are employed ethically and effectively to enhance student learning outcomes.