The direct effect of protein starvation on protein breakdown and synthesis in regions of the cultured early chick embryo

Klein, Norman W.; Yager, James D.; Hagedorn, Karen

doi:10.1016/0012-1606(71)90094-7

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Protein Deprivation During Early1

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1971

1978

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Cited by 6 publications

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“…Thus, similar to studies in various other systems (Munro, 1968) protein nutrition and the availability of amino acids may have a direct effect on the level of ribosomes within a cell which ultimately may play a central role in growth regulation during early embryonic development. Prom Klein et al (1971). Summarized from Tables 1, 2, 3, and 4B in Clarkson et al (1969).…”

Section: Protein Deprivation During Earlymentioning

confidence: 99%

Protein nutrition in growth regulation during early development

Klein¹

1973

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Section: Protein Deprivation During Earlymentioning

confidence: 99%

Protein nutrition in growth regulation during early development

Klein¹

1973

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The effect of protein deprivation on RNA and protein breakdown in subcellular fractions of the cultured chick embryo

Hickey

Klein

1973

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein

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During protein deprivation the brain, neural tube and extraembryonic membrane of the early chick embryo rapidly lose label from rRNA and protein. At the same time no decrease in the quantity of these macromolecules can be found in these regions. On the other hand, ribosomal turnover can not be demonstrated in the somites or heart of protein-deprived embryos nor in any region of growing embryos. During 36 h culture on complete growth medium, the brain, neural tube and membrane double their ribosome/cell ratio, while this ratio remains constant in the heart and somite regions. This ratio also remains constant in all regions during 36 h culture on proteindeprivation medium. The rapid ribosomal turnover seen in the sensitive regions of the starved embryo appears to be a mechanism whereby rRNA/DNA is held constant during growth inhibition of a previously rapidly multiplying cell population.

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Polysome activity in relation to growth and protein starvation in brains and hearts of cultured early chick embryos

Lynch¹,

Klein²

1978

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein

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The direct effect of protein starvation on protein breakdown and synthesis in regions of the cultured early chick embryo

Cited by 6 publications

References 19 publications

Protein nutrition in growth regulation during early development

Protein nutrition in growth regulation during early development

The effect of protein deprivation on RNA and protein breakdown in subcellular fractions of the cultured chick embryo

Polysome activity in relation to growth and protein starvation in brains and hearts of cultured early chick embryos

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