2018
DOI: 10.1186/s12891-018-2152-1
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The disappearance of femoral head and neck resulting from extensive bone defect caused by secondary syphilis: a case report and literature review

Abstract: BackgroundTreponema Pallidum (TP), the pathogen of syphilis, commonly infects bones in cases of congenital and tertiary syphilis, but it is rare in the primary and secondary stages. With its mild symptoms and rare clinical findings, it might be easy to dismiss the diagnosis of early syphilis. Usually, effective results can be achieved after the conventional strategy of antibiotic treatments, mainly penicillin. To our knowledge, our case is so far the most serious reported case of destructive bone lesion in sec… Show more

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Cited by 9 publications
(6 citation statements)
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“…After primary infection, typically resulting in a localized chancre, spirochetemia occurs quickly and organisms may invade nearly any organ system [ 4 ]. T. pallidum has a high affinity for bone, and bacteria are deposited into the bony periosteum, with inflammation extending into the Haversian canals and medulla [ 2 , 5 ]. Bone changes can develop as early as four weeks after primary chancre, and may appear as periostitis, destructive lesions, or a combination of both [ 6 , 7 ].…”
Section: Discussionmentioning
confidence: 99%
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“…After primary infection, typically resulting in a localized chancre, spirochetemia occurs quickly and organisms may invade nearly any organ system [ 4 ]. T. pallidum has a high affinity for bone, and bacteria are deposited into the bony periosteum, with inflammation extending into the Haversian canals and medulla [ 2 , 5 ]. Bone changes can develop as early as four weeks after primary chancre, and may appear as periostitis, destructive lesions, or a combination of both [ 6 , 7 ].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, if syphilis is suspected or confirmed in the setting of appropriate symptoms, further evaluation with imaging should be strongly considered. Bone lesions should not be ignored in this setting as advanced destruction can occur without appropriate therapy [ 2 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Primary syphilis is characterized by more than one chancre and inguinal lymphadenopathy, as well as laboratory confirmation of TP in clinical specimens by RPR and particle agglutination assay for antibody to TP (TPPA), or TP haemagglutination. Secondary syphilis is characterized by skin rash and lymphadenopathy, and confirmed by laboratory testing results for syphilis (12). Early latent syphilis is defined as patients within a year of asymptomatic syphilitic infection supported by positive laboratory testing results and normal cerebrospinal fluid (CSF).…”
Section: Methodsmentioning
confidence: 99%