The Discovery of Drugs from Higher Plants

Kinghorn, A. Douglas

doi:10.1016/b978-0-7506-9003-4.50010-1

Cited by 28 publications

(16 citation statements)

References 70 publications

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“…Several reviews pertaining to approaches for selecting plants as candidates for drug discovery programs have been published (8,(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27); however, most concern screening plants for anticancer or anti-HIV activity. We outline these approaches briefly before concentrating on the ethnomedical approach, the major topic of this review.…”

Section: Approaches To Drug Discovery Using Higher Plantsmentioning

confidence: 99%

The Value of Plants Used in Traditional Medicine for Drug Discovery

Fabricant¹,

Farnsworth²

2001

Environmental Health Perspectives

626

674

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Section: Approaches To Drug Discovery Using Higher Plantsmentioning

confidence: 99%

The Value of Plants Used in Traditional Medicine for Drug Discovery

Fabricant¹,

Farnsworth²

2001

Environmental Health Perspectives

626

674

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“…These metabolites are usually found in various parts of the plants like roots, leaves, shoots and bark. Many plants have therefore become sources of important drugs and as such the pharmaceutical industries have exploited traditional medicine as a source of bioactive agents that can be used in the preparation of synthetic medicine (Kinghorn, 1994). Natural products play important roles in drug discovery and development process, particularly in the field of infectious diseases, where 75% of these drugs are of natural origin (Newman et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

<i>In Vivo</i> Antitrypanosomal Effects Of Some Ethnomedicinal Plants From Nupeland Of North Central Nigeria

Mann¹,

Ifarajimi²,

Adewoye³

et al. 2010

Afr. J. Trad. Compl. Alt. Med.

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Four medicinal plants Acacia nilotica, Bombax buonopozense, Terminalia avicennioides and Zanthoxylum zanthoxyloides traditionally used for treatment of sleeping sickness in Nupeland were investigated for in vivo antitrypanosomal activity. Methanol extracts of different parts of each plant (stem barks and fruits) were obtained and evaluated for their in vivo antitrypanosomal activities against Trypanosoma brucei brucei. Phytochemical screening of the methanol extracts of each plant were performed by standard procedures. Methanol extracts of A. nilotica (stem bark), B. buonopozense (stem bark), T. avicennioides (round fruit) and Z. zanthoxyloides (stem bark) were effective on trypanosomes. The extracts of A. nilotica and B. buonopozense exhibited antitrypanosomal effects at 200 and 300 mg/kg body weight respectively. Doses were able to clear the parasites from circulation within 6 and 7 days of treatment respectively with prolonging survival period of up to 30 days. While the extracts of T. avicennioides and Z. zanthoxyloides showed trypanostatic effects and could not clear the parasites completely. The methanol extracts of these plants contain metabolites that are associated with antitrypanosomal effects; therefore, these medicinal plants may be sources of new compounds that may be active against T. b. brucei. This study has also justified the claim that some medicinal plants of Nupeland possess antitrypanosomal activity and could be useful in the management of trypanosomiasis.

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“…There are different approaches that can be used for selecting plants of potential therapeutic interest (Farnsworth and Bingel, 1977;Phillipson and Anderson, 1989;Vlietinck and Vanden Berghe, 1991;Kinghorn, 1994;Farnsworth, 1996;and Verpoorte, 2000). Search for the medicinal plants generally follow three main routes i.e., random, ethno (including ethnobotanical, ethnomedical and ethnopharmacological) and ecological search.…”

Section: Selection Of Plant For Potential Therapeutic Interestmentioning

confidence: 99%

A review on scientific technologies in practice to innovate plant based molecules and to improve herbal drug quality to overcome health problems

Gupta

Khandelwal

Prasad

et al. 2010

JANS

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Medicines obtained from drug plants and other sources are commonly called traditional medicines. They have played an important role in the treatment of several human diseases since ancient times. India possessed a great wealth of traditional health care system known as Ayurveda related to the use of plant species. The global market of herbal drugs has a great potential around the world. Demand of plant based medicines is also increasing among western countries because of a general consideration that most allopathic drugs are associated with more or less side effects. Many pharmaceutical companies are now manufacturing Ayurvedic phytopharmaceutical products. However, enough efforts have not been made to get suitable substitute of modern allopathic medicines from these traditionally used drug plants and herbal drugs. This traditional system of healthcare in India still needs extensive evidence-based scientific researches in promoting its therapies. This review paper deals with modern scientific approaches to find out new plant based molecules and to develop new technologies in a continuous process and should be applied in the practice to improve the quality of herbal drugs in Indian pharmaceutical industries. Critical assessment of quality assurance including researches on pharmacognosy, chemistry, pharmacology, antimicrobial activity and clinical studies carried out on various Ayurvedic medicinal plants are also being presented.

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The Discovery of Drugs from Higher Plants

Cited by 28 publications

References 70 publications

The Value of Plants Used in Traditional Medicine for Drug Discovery

The Value of Plants Used in Traditional Medicine for Drug Discovery

<i>In Vivo</i> Antitrypanosomal Effects Of Some Ethnomedicinal Plants From Nupeland Of North Central Nigeria

A review on scientific technologies in practice to innovate plant based molecules and to improve herbal drug quality to overcome health problems

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