The discovery of novel immunomodulatory medicinal plants by combination of historical text reviews and immunological screening assays

Ulriksen, Emilie Steinbakk; Butt, Hussain Shakeel; Ohrvik, Ane; Blakeney, Rebecca Angelica; Kool, Anneleen; Wangensteen, Helle; Inngjerdingen, Marit; Inngjerdingen, Kari Tvete

doi:10.1016/j.jep.2022.115402

Cited by 11 publications

(5 citation statements)

References 48 publications

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“…The structures are depicted in Figures 6-8. Azathioprine (9), an immunosuppressant agent, has the following side effects: medullar suppression, myalgia, pancreatitis, Enhance the levels of cytokines (IL-1, IL-2, and IFN-γ), a proliferation of lymphocytes, augmented active T cells, and induced T cell surface markers on prothymocytes [37] (3) Immunocynin (hemocyanin) Treat urinary bladder cancer Carry oxygen to the affected area [37] (4) Bestatin…”

Section: Immunosuppressant Drug and Plant Bioactive Moleculesmentioning

confidence: 99%

“…Among the prevention mechanism, which is also stated in the traditional health care system of different parts of the world, enhancing the human immune system is one solution to reduce the increasing incidence of diseases and deaths [ 8 ]. Immunotherapies using plant-sourced phytochemicals are now getting attraction to combat the spread of cancer, autoimmune disease, and infection [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Plants and Plant‐Derived Molecules as Natural Immunomodulators

Zebeaman,

Tadesse,

Bachheti

et al. 2023

BioMed Research International

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Background. Nowadays, the immunomodulatory properties of plants have been studied extensively with greater interest due to increasing awareness and combating the severity of immunomodulatory diseases. Scope and Approach. This paper highlights the efficacy of the available literature evidence on natural immunomodulators of plant origin and synthetic ones. In addition, several aspects of plants and their phytoconstituents responsible for immunomodulation have been discussed. Moreover, this review also discusses the mechanism involved in immunomodulation. Key Findings. One hundred fifty medicinal immunomodulatory plants are currently identified to find novel immunomodulatory drugs. Of these plants, the plant family Asteraceae also takes the first rank by offering 18 plant species (12%). Similarly of the plants studied so far, 40% belong to the Asteraceae family. Echinacea purpurea of this family is most known for its immunostimulating activity. The most prominent immune-active bioactive molecules are polyphenols, terpenoids, and alkaloids. Also, eight plant bioactive immunomodulators were checked for clinical trials and found in the market. These are six immunosuppressants, resveratrol, epigallocatechin-3-gallate, quercetin, colchicine, capsaicin, and andrographolide, and two immunostimulants, curcumin and genistein. Nowadays, there are a lot of polyherbal traditional medicinal products sold in the market and claimed to their immunomodulators. However, much work is still needed to find more active immunomodulatory agents. The mechanism by which immunomodulatory medicinal plant exert their effect is through the induction of cytokines and phagocyte cells and the inhibition of iNOS, PGE, and COX-2 synthesis.

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Section: Immunosuppressant Drug and Plant Bioactive Moleculesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Plants and Plant‐Derived Molecules as Natural Immunomodulators

Zebeaman,

Tadesse,

Bachheti

et al. 2023

BioMed Research International

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“…Especially since the beginning of the 21st century numerous historical studies have been conducted in ethnopharmacology, some of them with the aim to identify plants or other natural products that could be interesting candidates in the search of new medicines (for an overview of these studies, see Lardos, 2015). More recent studies have also begun to screen plants mentioned in historical sources from Europe for specific activity profiles such as anti-inflammatory, immunomodulatory, anti-infective or antibiotic activities (Wagner et al, 2017; Ulriksen et al, 2022). Among the plants analysed are also such that were used specifically for skin problems including wounds.…”

Section: Introductionmentioning

confidence: 99%

Dermatological plants and their uses in theReceptariumof Burkhard III from Hallwyl from 16^thcentury Switzerland – Data mining a historical text and preliminaryin vitroscreening

Stehlin,

Albert,

Frei

et al. 2024

Preprint

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Ethnopharmacological relevance: Historical texts on materia medica can be an attractive source of ethnopharmacological information. In recent decades, various research groups have investigated corresponding resources from Europe and the Mediterranean region, pursuing different objectives. Regardless of the method used in such a work, the indexing of textual information and its conversion into data sets useful for further investigations represents a significant challenge. Aim of the study: First of all, this study aims to systematically catalogue pharmaco-botanical information in the Receptarium of Burkhard from Hallwyl (RBH) in order to identify candidate plants in a targeted manner. Secondly, the potential of RBH as a resource for pharmacological investigations will be assessed by means of a preliminary in vitro screening. Materials and methods: We developed a relational database for the systematic recording of the parameters composing the medical recipes contained in the historical text. Focusing on dermatological recipes, we explored the mentioned plants and their uses by drawing on specific literature. The botanical identities (candidate species) suggested in the literature for the historical plant names were rated based on their plausibility of being the correct attribution. The historical uses were interpreted by consulting medical-historical and modern clinical literature. For the subsequent in vitro screening, we selected candidate species used in recipes directed at the treatment of inflammatory or infectious skin disorders and wounds. Plants were collected in Switzerland and their hydroethanolic crude extracts tested for possible cytotoxic effects and for their potential to modulate the release of IL-6 and TNF in LPS-stimulated whole blood and PBMCs. Results: The historical text analysis points up the challenges associated with the assessment of historical plant names. Often two or more plant species are available as candidates for each of the 161 historical plant names counted in the 200 dermatological recipes in RBH. At the same time, the 56 medicinal uses mentioned in these recipes illustrate, that the details provided in the text about the skin problem in question enable conclusions to be drawn based on which the presumed underlying medical condition and its pharmacological basis can be narrowed down. On this basis, 11 candidate species were selected for in vitro screening, four of which were used in RBH in herbal simple recipes and seven in a herbal compound formulation. None of the extracts tested showed a noteworthy effect on cell viability except for the sample of Sanicula europaea. Extracts were tested at 50 μg/mL in the whole blood assay, where especially Vincetoxicum hirundinaria or Solanum nigrum showed inhibitory or stimulatory activities. In the PBMC assay, the root of Vincetoxicum hirundinaria revealed a distinct inhibitory effect on IL-6 release (IC50 of 3.6 μg/mL). Conclusions: Using the example of RBH, this study illustrates a possible ethnopharmacological path from unlocking the historical text and its subsequent analysis, through the selection and collection of plant candidates to their in vitro investigation. Fully documenting our approach to the analysis of historical texts, we hope to contribute to the discussion on solutions for the digital indexing of premodern information on the use of plants or other natural products.

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“…Before the development of the pharmaceutical industry, medicinal plants were used as the first treatment line to relieve different health disorders throughout the long human history (Elahee et al, 2019;Ren et al, 2021). The search for efficacious herbs and appropriate formulations that might be safe without inducing adverse effects leads to the conduction of different investigations in vitro and in vivo of natural products extracted from wild or cultivated plants (Kifle et al, 2022;Ulriksen et al, 2022). In parallel, different ethnopharmacological and survey studies were conducted on different traditional uses of different herbs or their derivatives to provide knowledge and insights into their beneficial properties as a framework for the experimental studies (Bellakhdar, 1989; Bellakhdar et al, 1991;Bellakhdar, 1997;Lekouch et al, 2001;Bnouham et al, 2006;Bnouham, 2010;Sana et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Corrigiola Litoralis Subsp. Telephiifolia (Pourr.) Briq.: an Extensive Review of Geographical Distribution, Phytochemical Content, Functionality, and Guidelines for Prospect Investigations

El Yaagoubi,

Soussi,

Saadia

et al. 2024

Ecol. Eng. Environ. Technol.

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Corrigiola telephiifolia is an aromatic and medicinal herb whose constituents hold worldwide interest for its various ethnopharmacological properties in the pharmaceutical field. This review provides a comprehensive analysis of the geographical distribution, phytochemical contents, traditional uses, and pharmacological properties of Corrigiola telephiifolia Pourr. Through an exhaustive search of primary databases, literature from 1950 to 2022 was examined, focusing on keywords to ensure inclusivity. The plant exhibits diverse physiological functions, potentially aiding in the prevention of diabetes, dyslipidemia, oxidative stress, and microbial infections while enhancing immunity. Similarly, we outlined recommendations for future research aimed at addressing existing gaps, and additional comprehensive studies are necessary to investigate the influence of climate change and other factors on the variability of chemical constituents. These endeavors would provide fresh perspectives on the biological characteristics of this species and offer guidance for future research initiatives.

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The discovery of novel immunomodulatory medicinal plants by combination of historical text reviews and immunological screening assays

Cited by 11 publications

References 48 publications

Plants and Plant‐Derived Molecules as Natural Immunomodulators

Plants and Plant‐Derived Molecules as Natural Immunomodulators

Dermatological plants and their uses in theReceptariumof Burkhard III from Hallwyl from 16^thcentury Switzerland – Data mining a historical text and preliminaryin vitroscreening

<i>Corrigiola Litoralis</i> <i>Subsp</i>. <i>Telephiifolia</i> (Pourr.) Briq.: an Extensive Review of Geographical Distribution, Phytochemical Content, Functionality, and Guidelines for Prospect Investigations

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The discovery of novel immunomodulatory medicinal plants by combination of historical text reviews and immunological screening assays

Cited by 11 publications

References 48 publications

Plants and Plant‐Derived Molecules as Natural Immunomodulators

Plants and Plant‐Derived Molecules as Natural Immunomodulators

Dermatological plants and their uses in theReceptariumof Burkhard III from Hallwyl from 16thcentury Switzerland – Data mining a historical text and preliminaryin vitroscreening

<i>Corrigiola Litoralis</i> <i>Subsp</i>. <i>Telephiifolia</i> (Pourr.) Briq.: an Extensive Review of Geographical Distribution, Phytochemical Content, Functionality, and Guidelines for Prospect Investigations

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Dermatological plants and their uses in theReceptariumof Burkhard III from Hallwyl from 16^thcentury Switzerland – Data mining a historical text and preliminaryin vitroscreening