Memory deficit is major health problem in normal life and in numerous psychiatric and neurodegenerative states during which patients forget recent happenings and become profoundly disabled, mute, immobile over 5-10 years. Brassica oleracea L. var. italica (Broccoli) was investigated for its anti-dementic activity on memory deficit induced by scopolamine (0.3 mg/kg, i.p.) in young male rats using behavioural models [elevated plus maze (EPM) & Morris water maze (MWM)]. Brain malondialdehyde (MDA), nitrite and reduced glutathione (GSH) biomarkers were also estimated to assess oxidative potential of broccoli. Its flower extract was prepared with hydro-alcohol (1:1) solvent using Soxhlet apparatus. Two doses (40 and 80 mg/kg, p. o.) of Hydro-alcoholic flower extract of Brassica oleracea L. var. italica (HFEBOI) were administered for four consecutive days to separate groups of rats. Chronic pretreatment with HFEBOI (40 and 80 mg/kg, p. o.) significantly and dose dependently improved learning and memory of rats, as indicated by increase in inflation ratio using EPM, and decrease in ELT during acquisition and increase in time spent in target quadrant (TSTQ) during retrieval using MWM. The drugs did not show any significant effect on loco-motor activity of the rat. Oxidative stress biomarkers (elevated brain MDA, nitrite and lower GSH levels) in scopolamine induced memory deficit in rats were significantly reversed by the flower extract. HFEBOI significantly reversed scopolamine induced memory deficit in rats. HFEBOI also significantly reduced brain acetylcholinesterase (AChE) activity of rats. The results indicated potential of HFEBOI in relieving memory deficit and oxidative stress induced by scopolamine. Anti-dementic mechanism of Brassica oleracea L. var. italica may be mediated through the inhibition of brain AChE activity by diindolylmethane, an anti-ChE and oxidative stress leading to rejuvenation of central nervous system that relieves dementia.