The discovery of SYP‐10913 and SYP‐11277: novel strobilurin acaricides

Abstract

Two compounds of particular interest, 6j (SYP-10913) and 6k (SYP-11277), exhibited potent acaricidal activity. The acaricidal potencies of these analogues are higher than that of fluacrypyrim in greenhouse applications, and are comparable with those of commercial acaricides such as spirodiclofen and propargite in field trials.

Intermediate derivatisation method in the discovery of new acaricide candidates: synthesis of N‐substituted piperazine derivatives and their activity against phytophagous mites

“…The acaricidal activities of compound 12 and the commercial positive controls spirodiclofen and pyridaben against eggs of spider mite ( T. cinnabarinus ) were measured on the basis of a previously reported procedure . Kidney bean plants with primary leaves expanded to 10 cm were selected and cut back to one plant per pot.…”

“…), were obtained by intermediate derivatisation methods (IDMs) – a practical approach to agrochemical discovery . IDMs use a three‐pronged approach to agrochemical discovery – the common intermediate method (CIM), the terminal group replacement method (TRM or RM) and the active compound derivatisation method (ADM or DM) . Among these three approaches, the common intermediate method has proved to be an effective and practical method .…”

Efficient Approach To Discover Novel Agrochemical Candidates: Intermediate Derivatization Method

“…36,37 Pyriminostrobin shows excellent efficacy against mites at various developmental stages and both good quick-acting and persistence activity. The detailed results are shown in Table 4.…”

Design, synthesis and structure–activity relationship of novel insecticidal dichloro‐allyloxy‐phenol derivatives containing substituted pyrazol‐3‐ols

“…The intermediate derivatisation method (IDM) strategy has been proposed for the discovery of novel bioactive compounds in agrochemicals . Based on commercial availability and potentially promising activities of some known intermediates, totally novel structures are built with excellent bioactivity.…”