The Discrepancy in Hardness between Clinical and Histopathological Findings in Localized Scleroderma Treated with PUVA

Abstract

Topical PUVA therapy was applied to a patient with localized scleroderma. Her localized scleroderma responded very well to the topical PUVA therapy, i.e., her sclerotic skin softened to normal skin texture. However, despite this dramatic clinical change the histopathological findings did not change at all and were still "hard".

Phototherapy in Scleroderma

“…No recurrence approximately 2 years laterNoAragane et al [101]Case report27/FLocalized sclerodermaPUVA0.4 J/cm 2 up to a total dose of 5 J/cm 2 UnavailableUnavailableUnavailableClinical improvement observed with reduced hardness. No recurrence after 20-month follow-upNoYamaguchi et al [102]Case report12/MPansclerotic morpheaPUVAUnavailableUnavailableUnavailableUnavailableImprovement in skin and ulceration that lasted 1.5 yearsUnknownWollina et al [103]Case report40/FPost-radiation morpheaPUVATwice weekly for 22 treatments (107.8 J/cm 2 ). Patient subsequently had 47 treatments of UVA1.…”