The disease burden of bronchiectasis in comparison with chronic obstructive pulmonary disease: a national database study in Korea

Yang, Bumhee; Choi, Hayoung; Lim, Jun Hyeok; Park, Hye Yun; Kang, Danbee; Cho, Juhee; Lee, Jae Seung; Lee, Sei Won; Oh, Yeon‐Mok; Moon, Ji-Yong; Kim, Sang‐Heon; Kim, Tae-Hyung; Yoon, Ho Joo; Lee, Hyun

doi:10.21037/atm.2019.11.55

Cited by 24 publications

(37 citation statements)

References 39 publications

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“…Extra-pulmonary comorbidities of bronchiectasis include many conditions such as connective tissue disease, inflammatory bowel disease, and immunodeficiency (9,13,14). In addition, low socioeconomic status and low family income were associated with bronchiectasis in subjects 40 years of age or older (12).…”

Section: Introductionmentioning

confidence: 99%

“…In several bronchiectasis cohort studies, patients with bronchiectasis were mainly elderly and females were more predominant than males (4)(5)(6). Previous pulmonary infectious conditions, such as pneumonia and tuberculosis (TB), chronic obstructive pulmonary disease (COPD), and asthma, are well established pulmonary comorbidities of bronchiectasis (7)(8)(9)(10)(11)(12). Extra-pulmonary comorbidities of bronchiectasis include many conditions such as connective tissue disease, inflammatory bowel disease, and immunodeficiency (9,13,14).…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with bronchiectasis in Korea: a national database study

Yang¹,

Jang²,

Chung³

et al. 2020

Ann Transl Med

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Background: Many important clinical features of bronchiectasis have been reported. However, the factors were evaluated using a specific disease cohort. Thus, clinical factors associated with bronchiectasis have not been well assessed in comparison to the general population. The aim of this study was to evaluate the factors associated with bronchiectasis using a national representative database.Methods: We conducted a cross-sectional study using data from the Korean National Health and Nutrition Examination Survey 2007-2009. To evaluate factors associated with bronchiectasis, a multivariable logistic analysis was used with adjustment for demographic and socioeconomic factors.Results: In the present study, the prevalence of bronchiectasis was 0.4%. Compared with subjects without bronchiectasis, subjects with bronchiectasis were older (55.1 vs. 44.4 years, P<0.001) and had lower body mass index (BMI) (23.2 vs. 24.2 kg/m 2 , P<0.001). The proportions of low family income (70.5% vs. 40.2%, P<0.001) and low educational level (less than high school) (85.3% vs. 70.6%, P=0.041) were higher in subjects with bronchiectasis than in subjects without bronchiectasis. Regarding comorbidities, subjects with bronchiectasis were more likely to have asthma (17.8% vs. 2.9%, P<0.001), previous history of pulmonary tuberculosis (TB) (43.5% vs. 5.0%, P<0.001), osteoporosis (19.1% vs. 7.8%, P=0.002), and depression (9.3% vs. 3.0%, P=0.015) compared with subjects without bronchiectasis. In addition, subjects with bronchiectasis had more respiratory symptoms and poorer quality of life measured using the EuroQoL five dimensions questionnaire (EQ-5D) index (0.87 vs. 0.93, P<0.001) than subjects without bronchiectasis. In multivariable logistic regression analysis, low family income (adjusted odds ratio, OR =3.83, 95% confidence interval,

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Factors associated with bronchiectasis in Korea: a national database study

Yang¹,

Jang²,

Chung³

et al. 2020

Ann Transl Med

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“…A study by Y ang et al . [ 21 ] showed that the prevalence of bronchiectasis in subjects aged 40 or more years was 0.8%, which was based on the 2007–2009 Korean National Health and Nutrition Examination Survey database. However, there was a possibility of recall bias and exclusion of patients with severe symptoms and inability to respond to the survey.…”

Section: Discussionmentioning

confidence: 99%

“…It was based on the 2012-2017 Health Insurance Review and Assessment Service, National Patient Sample (HIRA-NPS) database and the ICD-10 diagnostic code, which could underestimate the true prevalence of bronchiectasis. A study by Yang et al showed that the prevalence of bronchiectasis in subjects aged 40 or more years was 0.8%, which was based on the 2007-2009 Korean National Health and Nutrition Examination Survey database[21]. However, there was a possibility of recall bias and exclusion of patients with severe symptoms and inability to respond to the survey.…”

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confidence: 99%

Prevalence of asymptomatic bronchiectasis and associations among the health screening population in South Korea

Kim

Jung

et al. 2021

ERJ Open Res

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Despite the burden of bronchiectasis, there is little data from South Korea regarding asymptomatic bronchiectasis. We aimed to investigate the prevalence of bronchiectasis based on computed tomography (CT) findings, with emphasis on asymptomatic bronchiectasis (CT-proven) and its related factors.We analysed data of individuals who underwent chest CT at a South Korean health screening centre from 2016 to 2017. The prevalence of bronchiectasis was evaluated and adjusted by sex, age, and corresponding year for the Korean general population. Logistic regression analysis was performed to identify factors related to asymptomatic bronchiectasis by comparison between a group without bronchiectasis and a group with symptomatic bronchiectasis.Among the 27 617 subjects screened, 1005 were diagnosed with bronchiectasis based on CT findings, representing an adjusted prevalence of 2329/100 000. The adjusted prevalence of asymptomatic bronchiectasis was 1235/100 000, and that of symptomatic bronchiectasis was 1094/100 000. Compared with the non-bronchiectasis group, the factors related to asymptomatic bronchiectasis were female sex (odds ratio [OR], 1.41; 95% confidence interval [CI], 1.18–1.70), older age (OR, 1.06; 95% CI, 1.05–1.07), comorbid liver disease (OR, 1.32; 95% CI, 1.07–1.63) or chronic obstructive pulmonary disease (COPD; OR, 4.99; 95% CI, 2.88–8.64), history of tuberculosis (OR, 1.98; 95% CI, 1.46–2.68), and low forced expiratory volume in 1 second (FEV1; OR, 0.99; 95% CI, 0.98–0.998).In South Korea, the prevalence of asymptomatic bronchiectasis appeared higher than that of symptomatic bronchiectasis. Female sex, older age, liver disease, COPD, history of tuberculosis, and low FEV1 may be the factors related to asymptomatic bronchiectasis.

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“…COPD patients who frequently experience exacerbations have adverse impacts on their life quality, spirometry function, and prognosis [ 4 ]. Moreover, exacerbation also increases social and financial costs [ 5 , 6 ]. Consequently, effective and timely prevention of COPD exacerbation is of great significance for patients and medical workers.…”

Section: Introductionmentioning

confidence: 99%

Serum Levels of Gamma-Glutamyltransferase During Stable and Acute Exacerbations of Chronic Obstructive Pulmonary Disease

et al. 2020

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Background One of the most important factors in the pathogenesis of COPD (chronic obstructive pulmonary disease) is oxidative stress. GGT (gamma-glutamyltransferase) has been regarded as a novel marker of oxidative stress over the last few years. This study aimed to compare the serum levels of GGT during stable and acute exacerbations of COPD at a single center. Material/Methods The research included 117 patients with AECOPD (acute exacerbation of chronic obstructive pulmonary disease), 107 patients with stable COPD, and 112 control subjects. Serum GGT, spirometry function, and other clinical parameters (anthropometric and biochemical measurements) were evaluated and compared among the subjects. Results Serum GGT was elevated in patients with stable COPD in comparison to the control subjects. Its level was inversely related to lung function. It was also significantly higher in AECOPD patients compared to stable COPD patients. We also found that a GGT level of 21.2 IU/L displays a reliable diagnostic prediction of COPD and that a GGT level of 26.5 IU/L can be applied to predict the exacerbation of COPD. Conclusions Our research demonstrates that serum GGT level is inversely associated with pulmonary function and may serve as a biomarker during the progression of COPD. The monitoring of GGT values can be applied to evaluating COPD and its exacerbation risk.

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The disease burden of bronchiectasis in comparison with chronic obstructive pulmonary disease: a national database study in Korea

Cited by 24 publications

References 39 publications

Factors associated with bronchiectasis in Korea: a national database study

Factors associated with bronchiectasis in Korea: a national database study

Prevalence of asymptomatic bronchiectasis and associations among the health screening population in South Korea

Serum Levels of Gamma-Glutamyltransferase During Stable and Acute Exacerbations of Chronic Obstructive Pulmonary Disease

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