The Disorders of Endometrial Receptivity in PCOS and Its Mechanisms

Jiang, Nanxing; Li, Xuelian

doi:10.1007/s43032-021-00629-9

Cited by 46 publications

(33 citation statements)

References 141 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The defective endometrium causing recurrent abortion and implantation failure can also be responsible for it ( 11 ). Therefore, ovulation dysfunction and poor endometrial receptivity are the main factors of infertility in PCOS patients ( 17 ). Studies have shown that the change of oocyte competence (OC) may be linked to the low fertility of PCOS women, however, OC varies among PCOS phenotypes and associated morbidities ( 36 , 37 ).…”

Section: Discussionmentioning

confidence: 99%

“…PCOS patients’ impaired endometrial receptivity and reproductive outcomes may be affected by changes in numerous signal pathways as the disease progresses ( 17 , 42 , 43 ). In our study, the DEPs were shown to be involved in ferroptosis and mitochondrial dysfunction based on the KEGG pathway and subcellular location prediction system.…”

Section: Discussionmentioning

confidence: 99%

“…The main factor of adverse fertility is endometrial receptivity, which allows embryos to locate, adhere, and invade the uterine cavity ( 15 ). And reproductive outcomes were the best indicators of endometrial receptivity ( 16 , 17 ). To help PCOS patients improve their endometrial receptivity, it is critical to investigate new factors in PCOS patients’ impaired endometrial receptivity.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Quantitative Proteomics Reveals That a Prognostic Signature of the Endometrium of the Polycystic Ovary Syndrome Women Based on Ferroptosis Proteins

et al. 2022

View full text Add to dashboard Cite

ObjectiveWe aimed to study the relationship between ferroptosis proteins and reproductive outcomes of infertile patients with PCOS and construct the related prognostic model.MethodsThese endometrium samples of the study were collected from 33 women with PCOS and 7 control women with successful pregnancies at the Reproductive Center of Lanzhou University Second Hospital, September 2019 to September 2020. The 40 patients’ endometrium was identified the differentially expressed proteins (DEPs) using liquid chromatography tandem mass spectrometry. The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis and Gene Ontology (GO) showed that the DEPs related pathways and functions between PCOS and controls. Subsequently, univariate Cox regression analysis and Lasso regression were used to identifying independent prognostic ferroptosis proteins, which were utilized to establish a prognostic model. Then the performance of the prognostic model was evaluated by receiver operating characteristic curve (ROC) and decision curve analysis (DCA). Then clinical data and prognostic model were used to predict the reproductive outcomes of PCOS patients by constructing the nomograms. Finally, we performed the single sample gene set enrichment analysis (ssGSEA) to explore the correlation between risk scores and immune status.ResultsA total of 5331 proteins were identified, 391 proteins were differentially expressed in the PCOS and controls. The KEGG analysis revealed that the ferroptosis pathway was significantly different between PCOS and controls. 5 ferroptosis proteins (GPX4, DPP4, G6PD, PCBP1, and PCBP2) prognostic model (FerSig) was constructed via Cox regression and Lasso regression. Patients were separated into high and low-risk groups according to the FerSig. Kaplan-Meier curve showed that patients in the low-risk group had much better reproductive outcomes than those in the high-risk group. The DCA showed that the risk score was an independent predictive factor for reproductive outcomes. Compared with clinical data, ROC curve analysis indicated the FerSig proteins as a potential diagnostic and prognostic factor in PCOS patients. Functional analysis revealed that the FerSig proteins and immune microenvironment were correlated to the prognosis of PCOS.ConclusionThe prognostic model focused on the FerSig proteins could predict the reproductive outcomes of PCOS patients with decreased endometrial receptivity, and provided theoretical basis for individualized treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative Proteomics Reveals That a Prognostic Signature of the Endometrium of the Polycystic Ovary Syndrome Women Based on Ferroptosis Proteins

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Infine, è bene ricordare che l'alterata recettività endometriale e i disturbi ovulatori sono entrambi importanti cause d'infertilità correlata alla PCOS. Tuttavia, le alterazioni endometriali non hanno mai ricevuto la stessa attenzione della disfunzione ovulatoria [12].…”

Section: Fattori DI Rischio E Cause D'infertilità Femminileunclassified

Insulino-resistenza e fertilità nella donna con attenzione a sindrome dell’ovaio policistico (PCOS) e malattia epatica non alcoolica (NAFLD)

et al. 2022

View full text Add to dashboard Cite

SommarioIl fattore femminile costituisce un’alta percentuale delle cause d’infertilità di coppia. Tra le cause più frequenti d’infertilità femminile vi sono quelle correlate a un inadeguato stile di vita e alla presenza di sindrome metabolica. L’insulino-resistenza (IR) è uno dei punti cardine della sindrome metabolica ed è coinvolta anche nell’eziopatogenesi della sindrome dell’ovaio policistico (PCOS), frequente causa d’infertilità anovulatoria. Inoltre, l’IR è alla base di alcune delle complicanze della PCOS, come la malattia epatica non alcolica (NAFLD), a sua volta indirettamente correlata a problematiche di fertilità. In questa rassegna proveremo dunque a fornire al lettore degli spunti di riflessione sul complesso e affascinante ruolo dell’IR e delle disfunzioni a essa correlate, nel campo della fertilità femminile.

show abstract

“…There is ample evidence that polycystic ovary syndrome is an intrinsic syndrome, and in most of its clinical symptoms such as obesity and diabetes, traces of genetic variation might be seen [ 28 ]. The occurrence of alterations in the genes HOXA-10 and HOX-11 in women with polycystic ovary syndrome affects endometrial reception and might risk infertility with implantation failure [ 29 , 30 ]. Recent studies have shown that polymorphism in the FSHR gene is significantly associated with PCOS [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

A Review on CYP11A1, CYP17A1, and CYP19A1 Polymorphism Studies: Candidate Susceptibility Genes for Polycystic Ovary Syndrome (PCOS) and Infertility

Heidarzadehpilehrood

Pirhoushiaran

Abdollahzadeh

et al. 2022

Genes

View full text Add to dashboard Cite

Polycystic ovary syndrome is a multifactorial condition associated with reproductive and endocrine organs and might cause infertility and metabolic abnormalities in childbearing age. PCOS seems to be a multifactorial disorder resulting from the combination of several genetic and environmental factors. Little research has been conducted to date on the impact of polymorphisms in infertility. We aim to review the appearance of polymorphisms in females of diverse ethnicities and their effect on infertility in the population with polycystic ovary syndrome. There have been numerous reports of the importance of the steroidogenesis pathway and genetic variants in PCOS pathogenesis. The most important genes that play a role in the aetiology of PCOS are CYP11A1, CYP17A1, and CYP19A1. We evaluated the occurrence of polymorphisms in various ethnicities in the CYP11A1, CYP17A1, and CYP19A1 genes and their efficacy on increasing PCOS risk with infertility. Our findings revealed that polymorphisms in various ethnicities are associated with the risk of PCOS with infertility. Although conflicting results regarding CYP11A1, CYP17A1, and CYP19A1 polymorphisms and their influence on PCOS with infertility have been reported in a small number of papers, the authors feel this may be attributable to the sample size and ethnic composition of the examined populations. In conclusion, our study strongly suggests that the CYP11A1, CYP17A1, and CYP19A1 genes might significantly enhance the probability of developing PCOS with infertility.

show abstract

The Disorders of Endometrial Receptivity in PCOS and Its Mechanisms

Cited by 46 publications

References 141 publications

Quantitative Proteomics Reveals That a Prognostic Signature of the Endometrium of the Polycystic Ovary Syndrome Women Based on Ferroptosis Proteins

Quantitative Proteomics Reveals That a Prognostic Signature of the Endometrium of the Polycystic Ovary Syndrome Women Based on Ferroptosis Proteins

Insulino-resistenza e fertilità nella donna con attenzione a sindrome dell’ovaio policistico (PCOS) e malattia epatica non alcoolica (NAFLD)

A Review on CYP11A1, CYP17A1, and CYP19A1 Polymorphism Studies: Candidate Susceptibility Genes for Polycystic Ovary Syndrome (PCOS) and Infertility

Contact Info

Product

Resources

About