The Dispensatory of the United States of America

Wood, George B.; Bache, Franklin

doi:10.1097/00000441-186507000-00037

Cited by 29 publications

(14 citation statements)

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“…Therapeutic effects such as treatment of abdominal and chest pain, strengthening heart [9], treatment of menstrual bleeding, digestive problems [10], and anti inflammation has been described for R. damascena . A decoction of the root of R. damascena as a cough remedy to ease children’s cough [5] and the plant as a gentle laxative are also used [11].…”

Section: Introductionmentioning

confidence: 99%

Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart

et al. 2013

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BackgroundThe possible mechanism(s) of inotropic and chronotropic effects of the extract from Rosa damascena (R. damascena) on heart was examined.MethodsInotropic and chronotropic effects of four concentrations of the extract from R. damascena and isoprenaline were examined in isolated guinea-pig hearts perfused through aorta in a Langendorff model. All measurements were performed in three different groups: 1) In the presence and absence of propranolol, 2) In the presence and absence of methacholine and 3) In the presence of diltiazem (n = 12 for each group).ResultsIn all groups both isoprenaline and the extract caused an increase in heart rate and contractility (p < 0.05 to p < 0.001). Only in group 1, the final concentration of isoprenaline in the absence of propranolol caused significant greater increase in heart rate compared to the extract (207.6 ± 11.0 compared to 162.6 ± 11.8, p < 0.01). The percent increase in heart contractility due to the final concentration of the extract in the absence (362.4 ± 36.9 compared to 227.7 ± 31.6, p < 0.01) and presence of propranolol (577.1 ± 62.9 compared to 357.5 ± 45.6, p < 0.001) in group 1 and absence (403.7 ± 42.1 compared to 244.8 ± 18.9, p < 0.005) and presence of methcholine (499.88 ± 64.64 compared to 323.90 ± 44.49, p < 0.05) in groups 2 was significantly greater than the increase caused by isoprenaline.ConclusionsThe results of this study suggest that inotropic and chornotropic effect of R. damascena is possibly due to the stimulatory effect of this plant on beta-adrenoceptors.

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Section: Introductionmentioning

confidence: 99%

Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart

et al. 2013

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“…Typical examples include mentioning H. albus for Veratrum album (Woodville 1810), or H. niger for Melampodium, which has been named in Melampus' honor. Melampus, an ancient mythological shepherd and healer recommended the milk of a goat, which had been fed on the herb of hellebore, for the daughters of King Proetus for madness (Wood and Bache 1839;Encyclopaedia Britannica 1910b). Gallic men soaked the arrows into ellebore during hunting (data by Plinius).…”

Section: Introductionmentioning

confidence: 99%

Ethnobotanical, historical and histological evaluation of Helleborus L. genetic resources used in veterinary and human ethnomedicine

Balázs

Filep

Ambrus

et al. 2020

Genet Resour Crop Evol

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The use of hellebore (Helleborus) species for medical purposes has a long-standing tradition. Our work aimed at providing a historical survey of their medicinal application in Europe, and data on current ethnobotanical use of H. purpurascens Waldst. et Kit. in Transylvania (Romania), compared with earlier records of this region and other European countries. While the chemistry and pharmacology of hellebores have been researched extensively, little is known about their anatomical traits. Thus, we intended to provide a detailed histological analysis of Helleborus odorus Waldst. et Kit., H. purpurascens, and H. niger L., based on transverse sections of aerial parts and root. Our survey revealed that H. purpurascens is known for immunotherapy, wounds, and as antiemetic drug in ethnoveterinary medicine, but not in human therapy in the study area. Distinctive histological characters included diverse stele structure in the root; sclerenchymatous bundle caps around compound vascular bundles in the stem and the main leaf veins of H. odorus; and amphistomatic leaves in H. purpurascens. Quantitative vegetative traits also revealed significant differences among species, but they may reflect environmental influences, too. In all three species the sepal was hypostomatic with mesomorphic stomata, while the modified petal comprised a proximal nectar-producing and a distal non-secretory part. Distinctive floral traits included shape of modified petal, presence of papillae and thickness of nonsecretory part; as well as ornamentation of tricolpate pollen grains. Our findings suggest that the anatomy of various plant parts varies slightly with each species, including ethnomedicinally known H. purpurascens, even though the basic structure is the same within the genus.

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“…The theraputical effects of Rosa damascena L. are due to its anti-inflammatory [10], analgesic, hypnotic, and antispasmodic [9, 11] properties. Antioxidant and antidiabetic [12, 13], heart inotropic [14], usefulness in treatment of menstrual bleeding [15], antitussive [16], tracheal relaxant [17], and relaxing activity [18] are the other effects that attributed to Rosa damascena L. …”

Section: Introductionmentioning

confidence: 99%

Assessment of Safety and Therapeutic Efficacy ofRosa damascenaL. andQuercus infectoriaon Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach

Joukar

Askarzadeh

Shahouzehi

et al. 2013

Journal of Toxicology

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According to the use of Quercus infectoria (QI) and Rosa damascena L. (RD) for therapeutic purposes and lack of adequate information about their cardiovascular effects, we investigated the cardiovascular indices of rabbits which chronically pretreated with these agents. Animal groups were control group (CTL), RD and QI groups with normal chow plus 1.5 g RD and QI extracts, respectively, in each kg of the diet for 45 days; Hyperlipidemic (H) group received high-fat diet for 45 days; H+RD and H+QI groups received high fat diet plus QI and RD extracts, respectively. Blood pressure was greater in H+RD group than CTL, RD, and H groups. Left ventricular developed pressure and left ventricular systolic pressure increased significantly in H+RD group versus CTL and RD groups (P < 0.05 and P < 0.0001, resp.) and in H+QI groups (P < 0.01 versus QI groups). Left ventricular end diastolic pressure (LVEDP) showed significant reduction in H+QI group versus H group. QI attenuated the values of total cholesterol, LDL, TG, and atherogenic indices of plasma when coadministrated with a high-fat diet. The results suggest the antilipidemic and antiatherogenic effects of QI. In addition, the use of RD along with a high-fat diet may increase the risk of hypertension in rabbits.

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The Dispensatory of the United States of America

Cited by 29 publications

References 0 publications

Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart

Possible mechanism of inotropic and chronotropic effects of Rosa damascena on isolated guinea pig heart

Ethnobotanical, historical and histological evaluation of Helleborus L. genetic resources used in veterinary and human ethnomedicine

Assessment of Safety and Therapeutic Efficacy ofRosa damascenaL. andQuercus infectoriaon Cardiovascular Performance of Normal and Hyperlipidemic Rabbits: Physiologically Based Approach

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