The Disposition of Orally Administered Cholestyramine-C14

Gallo, Duane G.; Sheffner, A. Leonard

doi:10.3181/00379727-120-30453

Cited by 18 publications

(6 citation statements)

References 2 publications

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“…Cholestyramine is a nonabsorbable bile acid-binding anion exchange resin, and its administration brings about interruption of the enterohepatic circulation of bile acids (1). Clinically, cholestyramine is widely used as a hypocholesterolemic agent in man (2,3).…”

Section: Lipids 22 513-516 (1987)mentioning

confidence: 99%

Effect of cholestyramine on bile acid metabolism in conventional rats

Imai

Kawata

Inada

et al. 1987

Lipids

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Effects of cholestyramine on biliary secretion of cholesterol, phospholipids and bile acids and fecal excretion of sterols and bile acids were examined in Wistar male rats. Six rats were fed a basal diet, and the other six were fed a basal diet supplemented with 5% cholestyramine for eight days. Bile flow and biliary secretion of bile acids and phospholipids (per hour per rat) decreased with cholestyramine treatment, while biliary cholesterol secretion (per hour per rat) remained unchanged. In the biliary bile acid composition, a marked increase of chenodeoxycholic acid with a concomitant decrease of beta-muricholic acid was observed in cholestyramine-treated rats. Fecal excretion of total sterols and bile acids increased about three- and four-fold, respectively, after cholestyramine treatment. The increase of fecal bile acids derived from cholic acid was more predominant than that derived from chenodeoxycholic acid, resulting in an increase of the cholic acid group/chenodeoxycholic acid group ratio.

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Section: Lipids 22 513-516 (1987)mentioning

confidence: 99%

Effect of cholestyramine on bile acid metabolism in conventional rats

Imai

Kawata

Inada

et al. 1987

Lipids

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“…One candidate is colestyramine, a synthetic bile acid‐sequestering particulate resin formerly used as a cholesterol‐lowering agent 5 . There is evidence to suggest that colestyramine enhances CCK secretion 6–8 and crucially, as it is not absorbed, it can have no potentially confounding postabsorptive effects 9 …”

Section: Introductionmentioning

confidence: 99%

Colestyramine slows gastric emptying of liquids and reduces appetite in healthy subjects

Psichas

Little

Lal

et al. 2012

Neurogastroenterology Motil

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This study provides the first evidence that colestyramine significantly slows liquid gastric emptying and reduces appetite in healthy humans. Colestyramine therefore presents an attractive gut-brain signaling research tool in that it is not absorbed and thus lacks potentially confounding postabsorptive effects. Furthermore, with clear effects on gastric emptying and appetite, colestyramine now merits consideration as a trial therapeutic strategy for appetite suppression and weight loss.

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“…It is used as the chloride salt, which is neutral in reaction, and is not absorbed or digested in the gastrointestinal tract (2). When given in the appropriate dosage it has been shown to reduce the blood cholesterol levels in hypercholesterolemic cockerels (2,3), dogs (4), rabbits (5), and man (6)(7)(8)(9), and in normocholesterolemic cockerels, dogs (1), and man (9). It has been reported to produce increased fecal excretion of both bile acids and neutral sterols in the dog (1) and the pig (10), and of bile acids alone in the rat (11,12).…”

Section: Introductionmentioning

confidence: 99%