The disseminated intravascular coagulation score is a novel predictor for portal vein thrombosis in cirrhotic patients with hepatitis B

Cui, Shujie; Fu, Zhenmei; Feng, Yuemin; Xie, Xiaoyu; Ma, Xiaowen; Liu, Tiantian; Wang, Le; Wu, Hao; Zhu, Qiang

doi:10.1016/j.thromres.2017.11.010

Cited by 13 publications

(14 citation statements)

References 24 publications

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“…( 113‐118 ) Decreased velocity of PV flow at baseline has been recognized as a risk factor for PVT in patients with cirrhosis in several studies, albeit with varied predictive value. ( 117‐120 ) Some studies have identified specific thresholds of portal flow associated with increased risk of PVT, ranging from 10 to 15 cm/s, as determined by Doppler ultrasonography. ( 117,119,121 ) A meta‐analysis demonstrated an increased incidence in PVT in patients with cirrhosis taking nonselective beta‐blockers (OR, 4.62; 95% CI, 2.50‐8.53; P < 0.001; I 2 = 80%; P < 0.001).…”

Section: Pvt Prevalence and Risk Factors: Patients With Cirrhosismentioning

confidence: 99%

Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases

et al. 2021

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Section: Pvt Prevalence and Risk Factors: Patients With Cirrhosismentioning

confidence: 99%

Vascular Liver Disorders, Portal Vein Thrombosis, and Procedural Bleeding in Patients With Liver Disease: 2020 Practice Guidance by the American Association for the Study of Liver Diseases

et al. 2021

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“…There is strong evidence showing abnormal hemostasis linked to inflammation during viral infections in humans (8, 9, 59, 60). In animals, some viral infections like Ebola and influenza have been used to study thrombosis.…”

Section: Models To Study Thrombosis Induced By Infectionmentioning

confidence: 99%

Understanding Infection-Induced Thrombosis: Lessons Learned From Animal Models

Beristain‐Covarrubias

et al. 2019

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Thrombosis is a common consequence of infection that is associated with poor patient outcome. Nevertheless, the mechanisms by which infection-associated thrombosis is induced, maintained and resolved are poorly understood, as is the contribution thrombosis makes to host control of infection and pathogen spread. The key difference between infection-associated thrombosis and thrombosis in other circumstances is a stronger inflammation-mediated component caused by the presence of the pathogen and its products. This inflammation triggers the activation of platelets, which may accompany damage to the endothelium, resulting in fibrin deposition and thrombus formation. This process is often referred to as thrombo-inflammation. Strikingly, despite its clinical importance and despite thrombi being induced to many different pathogens, it is still unclear whether the mechanisms underlying this process are conserved and how we can best understand this process. This review summarizes thrombosis in a variety of models, including single antigen models such as LPS, and infection models using viruses and bacteria. We provide a specific focus on Salmonella Typhimurium infection as a useful model to address all stages of thrombosis during infection. We highlight how this model has helped us identify how thrombosis can appear in different organs at different times and thrombi be detected for weeks after infection in one site, yet largely be resolved within 24 h in another. Furthermore, we discuss the observation that thrombi induced to Salmonella Typhimurium are largely devoid of bacteria. Finally, we discuss the value of different therapeutic approaches to target thrombosis, the potential importance of timing in their administration and the necessity to maintain normal hemostasis after treatment. Improvements in our understanding of these processes can be used to better target infection-mediated mechanisms of thrombosis.

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“…Another prospective study found an association on univariate analysis. However, multivariate analysis was not performed and the AUC using portal flow velocity for predicting portal vein thrombosis was small (0.709) . Nevertheless, another retrospective survey of longitudinal cases and a prospective longitudinal study did not confirm these results.…”

Section: Portal Vein Thrombosis In Patients With Cirrhosismentioning

confidence: 96%