A round a third of people will experience depression after having a stroke. Depression after stroke is associated with reduced quality of life, poorer medication compliance, and greater morbidity and mortality. It has historically been underdiagnosed and undertreated, despite recommendations that all individuals who have had a stroke be screened for mental health problems. The following article describes what is known about depression after stroke, drawing on National Institute for Health and Care Excellence guidelines. Steps to overcome challenges in assessment within general practice are presented, in addition to ways of achieving an effective biopsychosocial management strategy that promotes recovery, community engagement and effective carer support. The GP curriculum and depression after stroke Clinical module 3.10: Care of people with mental health problems requires GPs to:. Recognise that depression and anxiety are common in people with long-term physical conditions, and increase the morbidity and mortality from these conditions. Understand the place of instruments in case-finding for depression and for assessment of severity of symptoms. Appropriately explore both physical and psychological symptoms, family, social and cultural factors, in an integrated manner