The distribution and composition of serum lipoproteins in eighteen animals

Mills, G.L.; Taylaur, C.E.

doi:10.1016/0305-0491(71)90234-3

Cited by 90 publications

(74 citation statements)

References 17 publications

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“…The LDL are rich in cholesteryl esters (39 %) and VLDL rich in triglycerides (41 %), The relative constancy in the phospholipid content of ovine lipoproteins (22-26%) is also a characteristic of man [see Magnani and Howard, 1972]. A good estimate of the total lipoprotein content Nelson [1973] and Mills and Taylaur [1971]. Quanti-Leat, Kubasek and Buttress tatively, sheep and human plasma contain similar concentrations of HDL but markedly different amounts of LDL.…”

Section: Resultsmentioning

confidence: 99%

Plasma Lipoproteins of Lambs and Sheep

1976

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The major plasma lipoproteins of the adult sheep were high density lipoprotein (76%) having α‐mobility on electrophoresis and low density lipoprotein (20%) having β‐mobility. Chylomicrons and very low density lipoproteins were minor constituents (<5%). The postabsorptive hyperlipidaemia in suckling lambs is mainly a result of increased concentration of low density and high density lipoproteins although the relative contribution of very low density lipoproteins was increased to 7—15% of the total lipoproteins. The hyperlipidaemia was markedly greater in an intact male lamb than in female or castrated male lambs. In suckling lambs a new lipoprotein (density 1·090 g/ml) appeared in the high density lipoprotein fraction but disappeared before weaning.

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Section: Resultsmentioning

confidence: 99%

Plasma Lipoproteins of Lambs and Sheep

1976

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“…However, subsequent work clearly showed that, depending on the cell size and the experimental conditions, conversion of glucose into acylglycerol fatty acids takes place in vitro in human adipose tissue (Goldrich et al, 1969;Smith, 1971). In addition, some similarity exists in the chemical composition (Mills & Taylaur, 1971) and in the nature of the protein components of rat and human very-low-density lipoproteins (Bersot et al, 1970;Swaney et al, 1977). Our results should however be confirmed in an homologous system.…”

Section: Stimulation Of Lipogenesis By Very-low-density Lipoproteinmentioning

confidence: 55%

“…The protein concentration of very-low-density lipoprotein in normal human plasma is about 100,ug/ml (Mills & Taylaur, 1971). The concentration of lipoproteins in extravascular fluids is not known with accuracy.…”

Section: Stimulation Of Lipogenesis By Very-low-density Lipoproteinmentioning

confidence: 99%

Stimulation of triacylglycerol synthesis in rat adipocytes by plasma very-low-density lipoproteins

Thomopoulos¹,

Berthelier²,

Lagrange³

et al. 1978

Biochemical Journal

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The effect of human plasma lipoproteins on lipogenesis from glucose has been studied in isolated rat adipocytes. The very-low-density lipoproteins increased lipogenesis specifically, whereas low-density lipoproteins and high-density lipoproteins were without effect. Such stimulation could be reproduced with partially delipidated very-low-density lipoproteins. Non-esterified fatty acids and glycerol were also without effect. Pretreatment of the adipocytes with trypsin did not alter the effect of very-low-density lipoprotein. The presence of Ca2+ was required for the full activation of lipogenesis. The synthesis of acylglycerol fatty acids and of acylglycerol glycerol were equally increased. The effect of very-low-density lipoprotein was not additive to that of insulin. It is suggested that very-low-density lipoprotein may directly stimulate lipogenesis in fat-cells, particularly in states when the lipoproteins are present at high concentration in the circulation.

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“…This questioning was based on several investigations carried out in the 70's. In 1975, Keys [2] based on several epidemiological studies [3][4][5] reported that LDL-C levels in industrialized societies compared with those in non-industrialized societies were excessively high; he also established that LDL-C levels in non-human mammals are less than 50 mg/dL, similar to those of newborn human mammals, and that in the latter, the LDL-C levels are doubled in adolescence and quadrupled in adulthood ( Figure 1). In 1978, the English group of Reich and Myant in collaboration with the American group of Brown and Goldstein [6] demonstrated that, in "in vitro" studies with the use of radioactive I-labeled LDL, LDL receptors (LDLR) were saturated with an average plasma LDL level of 25 mg/dL, equivalent to 2.5 mg/dL in lymph (Figure 2), likewise, they demonstrated that with this LDL level, the enzymatic activity of the Hydroxy-MethylGlutaryl-Coenzyme-A Reductase (HMGCoAR)-pivotal enzyme of the cellular cholesterol synthesis was completely inhibited.…”

Section: Biologically Active or Physiological Level Of Ldl Cholesterolmentioning

confidence: 99%