The distribution and radiation effects of intravenously administered colloidal Au198 in man

Root, Samuel W.; Andrews, Gould A.; Kniseley, Ralph M.; Tyor, Malcolm P.

doi:10.1002/1097-0142(195409)7:5<856::aid-cncr2820070506>3.0.co;2-a

Cited by 68 publications

(29 citation statements)

References 6 publications

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“…6a) via systemic administration of gold nanoparticles and therapeutic nanocarriers employed EGFR-specific antibody–conjugated 60-nm gold nanoparticles (GNPs) and therapeutic drug–loaded nanocarriers (TN). These GNPs are known as colloidal gold, the type of gold nanoparticles used in the clinic for more than 50 years 3,4,40,41 . They were conjugated with the clinically approved for HNSCC treatment antibodies against EGFR, Erbitux (ImClone Systems Inc., Branchburg, NJ) (C225) 5 .…”

Section: Methodsmentioning

confidence: 99%

“…Nanospectra Biosciences, Inc.; Efficacy Study of AuroLase Therapy in Subjects With Primary and/or Metastatic Lung Tumors, available from http://clinicaltrials.gov/ct2/show/NCT01679470/, with NLM identifier NCT01679470), but their high doses and nonspecific uptake coupled with thermal diffusion do not improve cancer cell specificity or lower systemic toxicity. In contrast, our new method of PNB generation with a short near-infrared laser pulse 18 allows the combination of clinically validated gold colloids 3,4,40,41 (instead of the less safe, engineered, near-infrared GNPs) with safe, deep-penetrating near-infrared light and reduces the therapeutic optical dose by several orders of magnitude compared to other laser- and GNP-based therapies 46,48–50 .…”

Section: Methodsmentioning

confidence: 99%

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On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles

Lukianova‐Hleb¹,

Ren²,

Sawant³

et al. 2014

Nat Med

157

149

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Chemoradiation-resistant cancers limit treatment efficacy and safety. We show here the cancer cell–specific, on-demand intracellular amplification of chemotherapy and chemoradiation therapy via gold nanoparticle– and laser pulse–induced mechanical intracellular impact. Cancer aggressiveness promotes the clustering of drug nanocarriers and gold nanoparticles in cancer cells. This cluster, upon exposure to a laser pulse, generates a plasmonic nanobubble, the mechanical explosion that destroys the host cancer cell or ejects the drug into its cytoplasm by disrupting the liposome and endosome. The same cluster locally amplifies external X-rays. Intracellular synergy of the mechanical impact of plasmonic nanobubble, ejected drug and amplified X-rays improves the efficacy of standard chemoradiation in resistant and aggressive head and neck cancer by 100-fold in vitro and 17-fold in vivo, reduces the effective entry doses of drugs and X-rays to 2–6% of their clinical doses and efficiently spares normal cells. The developed quadrapeutics technology combines four clinically validated components and transforms a standard macrotherapy into an intracellular on-demand theranostic microtreatment with radically amplified therapeutic efficacy and specificity.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles

Lukianova‐Hleb¹,

Ren²,

Sawant³

et al. 2014

Nat Med

157

149

View full text Add to dashboard Cite

show abstract

“…Colloidal gold has been safely used to treat rheumatoid arthritis for half a century (29, 30), and recent work indicates that nanoparticles of pegylated gold—that is, colloidal gold coated with a protective layer of polyethylene glycol (PEG)—exhibit excellent in vivo biodistribution and pharmacokinetic properties upon systemic injection (31–33). In contrast to cadmium-containing QDs and other toxic or immunogenic nanoparticles, gold colloids have little or no long-term toxicity or other adverse effects in vivo (34, 35).…”

Section: Nanotechnologymentioning

confidence: 99%

Nanotechnology Applications in Surgical Oncology

Singhal¹,

2010

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Surgery is currently the most effective and widely used procedure in treating human cancers, and the single most important predictor of patient survival is a complete surgical resection. Major opportunities exist to develop new and innovative technologies that could help the surgeon to delineate tumor margins, to identify residual tumor cells and micrometastases, and to determine if the tumor has been completely removed. Here we discuss recent advances in nanotechnology and optical instrumentation, and how these advances can be integrated for applications in surgical oncology. A fundamental rationale is that nanometer-sized particles such as quantum dots and colloidal gold have functional and structural properties that are not available from either discrete molecules or bulk materials. When conjugated with targeting ligands such as monoclonal antibodies, peptides, or small molecules, these nanoparticles can be used to target malignant tumor cells and tumor microenvironments with high specificity and affinity. In the “mesoscopic” size range of 10–100 nm, nanoparticles also have large surface areas for conjugating to multiple diagnostic and therapeutic agents, opening new possibilities in integrated cancer imaging and therapy.

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“…In fact, colloidal gold has been safely used to treat rheumatoid arthritis for half a century (Root et al 1954;Merchant 1998). Recent work has indicated that pegylated gold nanoparticles (colloidal gold particles coated with a protective layer of polyethylene glycol [PEG]) exhibit excellent in vivo biodistribution and pharmacokinetic properties after systemic injection (Paciotti et al 2006;James et al 2007;Qian et al 2008).…”

Section: Biological Activity Of Immobilized Peptidementioning

confidence: 99%

“…Considering that colloidal gold has been safely used to treat rheumatoid arthritis forhalf a century (Root et al 1954;Merchant 1998), multivalent ligands based on gold particles are expected to be candidates for medical applications.…”

Section: Introductionmentioning

confidence: 99%

Peptide immobilized on gold particles enhances cell growth

Gong

Ito

2008

Cytotechnology

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A multivalent ligand of thrombopoietin (TPO) was prepared by immobilization of mimetic peptides on gold particles. An effective peptide ligand containing cysteine was designed to enhance the growth of TPO-sensitive cells. The peptide was then immobilized on gold particles by self assembly. The multivalent ligand enhanced the growth of TPO-dependent cells and its activity was more than that of the monovalent ligand.

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The distribution and radiation effects of intravenously administered colloidal Au198 in man

Cited by 68 publications

References 6 publications

On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles

On-demand intracellular amplification of chemoradiation with cancer-specific plasmonic nanobubbles

Nanotechnology Applications in Surgical Oncology

Peptide immobilized on gold particles enhances cell growth

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