The distribution and retention of plutonium, americium and uranium in CBA/H mice

Ellender, M.; Haines, Jackie; Harrison, John

doi:10.1177/096032719501400109

Cited by 15 publications

(6 citation statements)

References 37 publications

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“…Such diffusion was absent or less pronounced in rodents (Kisieleski et al., 1952; Priest et al., 1982). Autoradiographic studies of 233 U in mice at 1 d and 224 d after injection indicate an initial deposition of uranium on bone surfaces and subsequent burial of lines of activity, as well as some evidence of diffuse activity within bone mineral (Ellender et al., 1995). In all species for which there are data, there is evidence of similarity to calcium in that return of uranium from bone to plasma occurs at rates that are greater than could be attributed to bone resorption alone. (914) Parameter values for uptake and retention in the skeleton were based on data from the Boston study, animal data, post-mortem measurements on environmentally and occupationally exposed humans, analogy with the alkaline earth elements, and considerations of bone metabolism.…”

Section: Uranium (Z = 92)mentioning

confidence: 99%

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

Paquet¹,

Bailey²,

Leggett³

et al. 2017

Ann ICRP

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234

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The 2007 Recommendations of the International Commission on Radiological Protection (ICRP, 2007) introduced changes that affect the calculation of effective dose, and implied a revision of the dose coefficients for internal exposure, published previously in the Publication 30 series (ICRP, 1979, 1980, 1981, 1988) and Publication 68 (ICRP, 1994). In addition, new data are now available that support an update of the radionuclide-specific information given in Publications 54 and 78 (ICRP, 1988a, 1997b) for the design of monitoring programmes and retrospective assessment of occupational internal doses. Provision of new biokinetic models, dose coefficients, monitoring methods, and bioassay data was performed by Committee 2, Task Group 21 on Internal Dosimetry, and Task Group 4 on Dose Calculations. A new series, the Occupational Intakes of Radionuclides (OIR) series, will replace the Publication 30 series and Publications 54, 68, and 78. OIR Part 1 has been issued (ICRP, 2015), and describes the assessment of internal occupational exposure to radionuclides, biokinetic and dosimetric models, methods of individual and workplace monitoring, and general aspects of retrospective dose assessment. OIR Part 2 (ICRP, 2016), this current publication and upcoming publications in the OIR series (Parts 4 and 5) provide data on individual elements and their radioisotopes, including information on chemical forms encountered in the workplace; a list of principal radioisotopes and their physical half-lives and decay modes; the parameter values of the reference biokinetic model; and data on monitoring techniques for the radioisotopes encountered most commonly in workplaces. Reviews of data on inhalation, ingestion, and systemic biokinetics are also provided for most of the elements. Dosimetric data provided in the printed publications of the OIR series include tables of committed effective dose per intake (Sv Bq−1 intake) for inhalation and ingestion, tables of committed effective dose per content (Sv Bq−1 measurement) for inhalation, and graphs of retention and excretion data per Bq intake for inhalation. These data are provided for all absorption types and for the most common isotope(s) of each element. The electronic annex that accompanies the OIR series of publications contains a comprehensive set of committed effective and equivalent dose coefficients, committed effective dose per content functions, and reference bioassay functions. Data are provided for inhalation, ingestion, and direct input to blood. This third publication in the series provides the above data for the following elements: ruthenium (Ru), antimony (Sb), tellurium (Te), iodine (I), caesium (Cs), barium (Ba), iridium (Ir), lead (Pb), bismuth (Bi), polonium (Po), radon (Rn), radium (Ra), thorium (Th), and uranium (U).

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Section: Uranium (Z = 92)mentioning

confidence: 99%

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

Paquet¹,

Bailey²,

Leggett³

et al. 2017

Ann ICRP

Self Cite

234

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“…With the ‘high-fired’ materials, it increased throughout the 2 y, but only reached ∼1% IAD. In analyses carried out here, systemic model parameter values were shared between the four inhalation studies, and one on the biokinetics of plutonium following intraperitoneal injection of the citrate into mice (Ellender et al., 1995). Results are given in Table 22.6.…”

Section: Plutonium (Z = 94)mentioning

confidence: 99%

ICRP Publication 141: Occupational Intakes of Radionuclides: Part 4

et al. 2019

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“…By decreasing the concentration of U(VI) in our experiments, we may have moved closer to realistic conditions. However, it must be stressed that the comparison remains complex, especially since uranium is not homogeneously distributed in bones and concentrates mainly in the remodeling areas (Priest et al 1982;Ellender et al 1995;Bourgeois et al 2015). This raises the possibility that, in vivo, substantial concentrations of U(VI) may be reached in bone remodeling compartments, which are specialized structures providing a confined microenvironment involved in the local regulation of remodeling and where exchanges of organic and mineral matrix constituents are thought to take place (Hauge et al 2001;Eriksen 2010).…”

Section: Discussionmentioning

confidence: 99%

“…The affinity of uranium for phosphate, one of the two main constituents of bone mineral, has been proposed to explain this behavior (Neuman and Neuman 1949). Since then, several studies have been conducted to examine the distribution of U(VI) in bone samples and have shown that this metal is rapidly fixed onto bone surfaces, preferentially on those undergoing active mineralization (Priest et al 1982;Rodrigues et al 2013;Bourgeois et al 2015) and become buried with time by the apposition of new bone (Ellender et al 1995;Bourgeois et al 2015). However, to date, no mechanism explaining the biomineralization of U(VI) is formally accepted.…”

Section: Introductionmentioning

confidence: 99%

Low doses of uranium and osteoclastic bone resorption: key reciprocal effects evidenced using new in vitro biomimetic models of bone matrix

et al. 2021

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Uranium is widely spread in the environment due to its natural and anthropogenic occurrences, hence the importance of understanding its impact on human health. The skeleton is the main site of long-term accumulation of this actinide. However, interactions of this metal with biological processes involving the mineralized extracellular matrix and bone cells are still poorly understood. To get a better insight of these interactions, we developed new biomimetic bone matrices containing low doses of natural uranium (up to 0.85 µg per cm 2 of uranium). These models were characterized by spectroscopic and microscopic approaches before being used as a support for the culture and differentiation of preosteoclastic cells. In doing so, we demonstrate that uranium can exert opposite effects on osteoclast resorption depending on its concentration in the bone microenvironment. Our results also provide evidence for the first time that resorption contributes to the remobilization of bone matrix-bound uranium. In agreement with this, we identified, by HRTEM, uranium phosphate internalized in vesicles of resorbing osteoclasts. Thanks to the biomimetic matrices we developed, this study highlights the complex mutual effects between osteoclasts and uranium. This demonstrates the relevance of these 3D models to further study the cellular mechanisms at play in response to uranium storage in bone tissue and thus better understand the impact of environmental exposure to uranium on human bone health.

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The distribution and retention of plutonium, americium and uranium in CBA/H mice

Cited by 15 publications

References 37 publications

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

ICRP Publication 137: Occupational Intakes of Radionuclides: Part 3

ICRP Publication 141: Occupational Intakes of Radionuclides: Part 4

Low doses of uranium and osteoclastic bone resorption: key reciprocal effects evidenced using new in vitro biomimetic models of bone matrix

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