The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain

Burnet, Philip W.J.; Eastwood, Sharon L.; Lacey, Karen L.; Harrison, Paul J.

doi:10.1016/0006-8993(95)00104-x

Cited by 262 publications

(166 citation statements)

References 35 publications

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“…Immunohistochemical studies reveal the presence of serotonin-1A (Aznar et al, 2003) and serotonin-2A (Jakab and Goldman-Rakic, 2000;Pazos et al, 1987b) receptors on nearly all CB-IR and PV-IR neurons. Moreover, serotonin-1A receptors are preferentially found in layer II of human prefrontal cortex (Burnet et al, 1995;Pazos et al, 1987a;Varnas et al, 2004) and PET studies show a significant reduction in radioligand binding to serotonin-1A receptors in depressed subjects (Bhagwagar et al, 2004a;Sargent et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

Rajkowska

O'Dwyer

Teleki

et al. 2006

Neuropsychopharmacol

372

234

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Post-mortem morphometric studies report reductions in the average density and size of cortical neurons in the dorsolateral prefrontal cortex (dlPFC) and orbitofrontal cortex (ORB) in major depressive disorder (MDD). The contribution of specific neuronal phenotypes to this general pathology in depression is still unclear. Post-mortem sections from the dlPFC and ORB regions of 14 subjects with MDD and 11 controls were immunostained to visualize calbindin-immunoreactive (CB-IR) and parvalbumin-immunoreactive (PV-IR) presumptive GABAergic neurons. A three-dimensional cell counting probe was used to assess the cell packing density and size of CB-IR neurons in layers II + IIIa and PV-IR neurons in layers III-VI. The density of CB-IR neurons was significantly reduced by 50% in depression in the dlPFC and there was a trend toward reduction in the ORB. The size of CB-IR somata was significantly decreased (18%) in depression in the dlPFC with a trend toward reduction in the ORB. In contrast, there was no difference in the density of PV-IR neurons between the depressed and control groups in the dlPFC. The size of PV-IR neuronal soma was unchanged in depressed compared to control subjects in either dlPFC or ORB. In depression, subpopulations of GABAergic neurons may be affected differently in dlPFC and ORB. A significant reduction in the density and size of GABAergic interneurons immunoreactive for calcium binding proteins was found predominantly in the dlPFC region. These cellular changes are consistent with recent neuroimaging studies revealing a reduction in the cortical levels of GABA in depression.

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Section: Discussionmentioning

confidence: 99%

GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

Rajkowska

O'Dwyer

Teleki

et al. 2006

Neuropsychopharmacol

372

234

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“…5HT 1A receptors reside in all the cortical layers, but most densely so in the superficial layers (Burnet et al, 1995). Agonists of 5HT 1A receptors evoke hyperpolarization of pyramidal neurons, unlike agonists of 5HT 2A receptors, which cause depolarization (Amargos-Bosch et al, 2004;Aghajanian and Marek, 1997;Cruz et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Parametric and Regional Maps of Free Serotonin 5HT1A Receptor Sites in Human Brain as Function of Age in Healthy Humans

Møller

Jakobsen

Gjedde

2007

Neuropsychopharmacol

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(Gjedde, 2003;Rosa-Neto et al, 2004), which extrapolates measures of specific binding to an estimated steady-state. We compared these estimates in the two age groups with results obtained with the conventional Logan Plot and Simplified Reference Tissue Method (SRTM) applied to both regions of interestbased as parametric analyses. The regional distribution of specific binding of free sites [ 11 C]WAY-100635 was similar to that reported in previous studies, with the highest pBs in limbic structures and the raphé nuclei. Although the results of the three methods differed, pBs in the elderly subjects consistently were lower than those of young subjects. Thus, the correlation between pB and age applied to regionsof-interest revealed significant decline of pB at the rate of 3 or 4% per decade, and a 10% decline of the global mean 5HT 1A receptor-pB in elderly relative to young subjects. The results demonstrate that the number of available 5HT 1A -binding sites declines with age.

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“…The human 5-HT2A receptor is a post-synaptic receptor present in many neocortical areas, but scarcely present in the hippocampus and completely absent in the raphe (7). Many actions of serotonergic agents are attributed to the 5-HT2A receptor, which appears to play a role in several physiological functions such as thermoregulation and sleep (5).…”

Section: Introductionmentioning

confidence: 99%

Is there an association between T102C polymorphism of the serotonin receptor 2A gene and urinary incontinence?

Schwanke

Bittencourt

Noronha

et al. 2007

Braz J Med Biol Res

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The regulation of bladder function is influenced by central serotonergic modulation. Several genetic polymorphisms related to serotonin control have been described in the literature. T102C polymorphism of the serotonin receptor 2A gene (5-HT2A) has been shown to be associated with certain diseases such as non-fatal acute myocardial infarction, essential hypertension, and alcoholism. In the present study, we examined the association between 5-HT2A gene polymorphism and urinary incontinence in the elderly. A case-control study was performed in 298 elderly community dwellers enrolled in the Gravataí-GENESIS Project, Brazil, which studies gene-environmental interactions in aging and age-related diseases. Clinical, physical, biochemical, and molecular analyses were performed on volunteers. 5-HT2A genotyping was determined by PCR-RFLP techniques using the HpaII restriction enzyme. The subjects had a mean age of 68.05 ± 6.35 years (60-100 years), with 16.9% males and 83.1% females. The C allele frequency was 0.494 and the T allele frequency was 0.506. The CC genotype frequency was 21.78%, the CT genotype frequency was 55.24% and the TT genotype frequency was 22.98%. We found an independent significant association between the TT genotype (35.7%) and urinary incontinence (OR = 2.06, 95%CI = 1.16-3.65). Additionally, urinary incontinence was associated with functional dependence and systolic hypertension. The results suggest a possible genetic influence on urinary incontinence involving the serotonergic pathway. Further investigations including urodynamic evaluation will be performed to better explain our findings.

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The distribution of 5-HT1A and 5-HT2A receptor mRNA in human brain

Cited by 262 publications

References 35 publications

GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

Parametric and Regional Maps of Free Serotonin 5HT1A Receptor Sites in Human Brain as Function of Age in Healthy Humans

Is there an association between T102C polymorphism of the serotonin receptor 2A gene and urinary incontinence?

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