The Distribution of Blood in Renal Glomerular Capillaries Is a New Physiological Parameter, Which Is Affected by Diabetes and ACE‐inhibition

Engbjerg, Jacob Schade; Sardella, Donato; Bordoni, Luca; Trepiccione, Francesco; Capasso, Giovambattista; Østergaard, Leif; Rhodes, George J.; Sandoval, Ruben M.; Ring, Troels; Molitoris, Bruce A.; Frische, Sebastian

doi:10.1096/fasebj.2019.33.1_supplement.748.11

Cited by 3 publications

(1 citation statement)

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“…Velocity analysis distinguishes them: medulla tracks move slowly (1-5 mm/s), cortex tracks range from 5 to 10 mm/s, and main vessel tracks accelerate (10-15 mm/s). This observation of cortex velocity aligns with earlier research studies 39,40 . Black outlayer tracks segment into two: high-velocity (12-14 mm/s) tracks cover short distances, possibly due to framerate limitations capturing swift flows.…”

Section: Resultssupporting

confidence: 93%

Whole organ volumetric sensing Ultrasound Localization Microscopy for characterization of kidney structure

Chabouh,

Denis,

Bodard

et al. 2023

Preprint

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Glomeruli are the filtration units of the kidney and their function relies heavily on their microcirculation. Despite its obvious diagnostic importance, an accurate estimation of blood flow in the capillary bundle within glomeruli defies the resolution of conventional imaging modalities. Ultrasound Localization Microscopy (ULM) has demonstrated its ability to image in-vivo deep organs in the body. Recently, the concept of sensing ULM or sULM was introduced to classify individual microbubble behavior based on the expected physiological conditions at the micrometric scale. In the kidney of both rats and humans, it revealed glomerular structures in 2D but was severely limited by planar projection. In this work, we aim to extend sULM in 3D to image the whole organ and in order to perform an accurate characterization of the entire kidney structure. The extension of sULM into the 3D domain allows better localization and more robust tracking. The 3D metrics of velocity and pathway angular shift made glomerular mask possible. This approach facilitated the quantification of glomerular physiological parameter such as an interior traveled distance of approximately 7.5 microns within the glomerulus. This study introduces a technique that characterize the complete kidney phisiology which can serve as a method to facilite pathology assessment. Furthermore, its potential for clinical relevance could serve as a bridge between research and practical application, leading to innovative diagnostics and improved patient care.

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Section: Resultssupporting

confidence: 93%

Whole organ volumetric sensing Ultrasound Localization Microscopy for characterization of kidney structure

Chabouh,

Denis,

Bodard

et al. 2023

Preprint

View full text Add to dashboard Cite

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Whole Organ Volumetric Sensing Ultrasound Localization Microscopy for Characterization of Kidney Structure

Chabouh,

Denis,

Bodard

et al. 2024

IEEE Trans. Med. Imaging

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Targeted Therapy for Glomerulonephritis Using Arterial Delivery of Encapsulated Etanercept

Shushunova

Mayorova

Prikhozhdenko

et al. 2023

IJMS

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Complex immunosuppressive therapy is prescribed in medical practice to patients with glomerulonephritis to help them overcome symptoms and prevent chronic renal failure. Such an approach requires long-term systemic administration of strong medications, which causes severe side effects. This work shows the efficiency of polymer capsule accumulation (2.8 ± 0.4 µm) containing labeled etanercept (100 μg per dose) in the kidneys of mice. The comparison of injection into the renal artery and tail vein shows the significant superiority of the intra-arterial administration strategy. The etanercept retention rate of 18% and 8% ID in kidneys was found 1 min and 1 h after injection, respectively. The capsules were predominantly localized in the glomeruli after injection in mice using a model of acute glomerulonephritis. Histological analysis confirmed a significant therapeutic effect only in animals with intra-arterial administration of microcapsules with etanercept. The proposed strategy combines endovascular surgery and the use of polymer microcapsules containing a high molecular weight drug that can be successfully applied to treat a wide range of kidney diseases associated with glomerular pathology.

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The Distribution of Blood in Renal Glomerular Capillaries Is a New Physiological Parameter, Which Is Affected by Diabetes and ACE‐inhibition

Cited by 3 publications

References 0 publications

Whole organ volumetric sensing Ultrasound Localization Microscopy for characterization of kidney structure

Whole organ volumetric sensing Ultrasound Localization Microscopy for characterization of kidney structure

Whole Organ Volumetric Sensing Ultrasound Localization Microscopy for Characterization of Kidney Structure

Targeted Therapy for Glomerulonephritis Using Arterial Delivery of Encapsulated Etanercept

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