The distribution of carbonate in enamel and its correlation with structure and mechanical properties

Xu, Changcheng; Reed, Rachel; Gorski, Jeffrey P.; Wang, Yong; Walker, Mary P.

doi:10.1007/s10853-012-6693-7

Cited by 84 publications

(80 citation statements)

References 39 publications

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“…falls in the range recorded for enamel (0.02-0.1) [40]. Increasing carbonate content is associated with a distortion in lattice structure and hence reduces the crystallinity of hydroxyapatite [40]. This could also explain the high crystallinity of NeoMTA Plus obtained in this study.…”

Section: Discussionsupporting

confidence: 55%

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Chemistry and Bioactivity of NeoMTA Plus™ versus MTA Angelus® Root Repair Materials

Zeid

Alamoudi

Khafagi³

et al. 2017

Journal of Spectroscopy

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Objectives. To analyse the chemistry and bioactivity of NeoMTA Plus in comparison with the conventional root repair materials. Method and Materials. Unhydrated and hydrated (initial and final sets) materials were analysed by Fourier transform infrared (FTIR) spectroscopy and X-ray diffraction (XRD). For bioactivity study, small holes of dentin discs were filled with either materials, immersed in PBS for 15 days, and analysed with FTIR and scanning electron microscope with energy dispersive X-ray (SEM/EDX). The calculation of crystallinity and carbonate/phosphate (CO 3 /PO 4 ) ratio of surface precipitates (from FTIR) and calcium/phosphate (Ca/P) ratio (from EDX) was statistically analysed using t-test or ANOVA, respectively, at 0.05 significance. Results. Both materials are tricalcium silicate-based that finally react to be calcium silicate hydrate. NeoMTA Plus has relatively high aluminium and sulfur content, with tantalum oxide as an opacifier instead of zirconium oxide in MTA Angelus. NeoMTA Plus showed better apatite formation, higher crystallinity and Ca/P but lower CO 3 /PO 4 ratio than MTA Angelus. SEM showed globular structure with a small particle size in NeoMTA Plus while spherical structure with large particle size in MTA Angelus. Conclusion. Due to fast setting, higher crystallinity, and better bioactivity of NeoMTA Plus, it can be used as a pulp and root repair material.

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Section: Discussionsupporting

confidence: 55%

“…The CO 3 /PO 4 ratio of NeoMTA Plus and MTA Angelus (0.12 ± 0.01 and 0.52 ± 0.01, resp.) falls in the range recorded for enamel (0.02-0.1) [40]. Increasing carbonate content is associated with a distortion in lattice structure and hence reduces the crystallinity of hydroxyapatite [40].…”

Section: Discussionmentioning

confidence: 84%

Chemistry and Bioactivity of NeoMTA Plus™ versus MTA Angelus® Root Repair Materials

Zeid

Alamoudi

Khafagi³

et al. 2017

Journal of Spectroscopy

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“…This gives an effective fingerprint of the Raman active bonds in a material which can then be elucidated to determine the approximate chemical composition of the tooth matrix. Human, [25][26][27][28] mammalian [29][30][31] and reptilian [32] teeth, bone [26,[33][34][35][36][37] and mineral hydroxyapatite with varying chemical substitutions [26,35,[38][39][40] have been studied extensively using Raman spectroscopy. Raman spectroscopy has been employed in both bulk and micro analysis of human teeth.…”

Section: Introductionmentioning

confidence: 99%

“…[45][46][47][48][49] Xu et al examined the correlation between the distribution of carbonate content in enamel and the associated structural and mechanical properties. [27] Univariate (peak width) and bivariate (carbonate to phosphate ratio) methods were employed to compare the Raman (chemical) information to hardness. An increase in carbonate in the enamel from the outer to inner enamel was associated with a decrease in crystallinity and a decrease in harness and elastic modulus.…”

Section: Introductionmentioning

confidence: 99%

Chemical and mechanical properties of snake fangs

Vuuren

Dickenson

Gordon

et al. 2016

J Raman Spectroscopy

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The composition of dental tissues and their interaction determines its mechanical properties. The mechanical properties and chemical composition of the teeth of extant reptiles are still poorly studied areas. As a preliminary study the fangs of four species of snakes and a human tooth were investigated through nanoindentation and Raman spectroscopy. The average elastic modulus values for the main body of the fangs ranged from 15.3 GPa to 24.6 GPa, and 19.1 GPa for the human dentine. Raman spectroscopy and principal component analysis (PCA) showed that snake fangs are similar in composition to human dentine, both of which comprised of hydroxyapatite and an organic matrix. The elastic modulus and hardness data were correlated to the Raman spectra using partial least squares regression (PLS). The spectral features which correlated with the elastic modulus would suggest that elastic modulus is dependent on the relative protein to mineral amounts in the tooth. The form of the phosphate and the relative levels of phosphate to organic components also appear to be governing factors for elastic modulus. The PLS of Raman spectra against the hardness gave very similar results. The small differences between snake fangs and human dentine appeared to be because of carbonate content, with higher levels of carbonate in the human tooth than the snake fangs.Snake fangs should be able to withstand large lateral forces. Human dentine aids in dissipating imposed loads. This similarity in the chemical composition of the snake fangs and human dentine supported the findings of the similarities in mechanical properties, which may be attributed to the similar functional demands of these biocomposites.

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“…These findings suggest a radiogenic effect on tooth structure with increasing radiation dose to the tooth. To better understand radiotherapy-induced DEJ instability leading to dentition breakdown, our group is focused on characterizing the structure, properties, and biochemical composition (Dusevich et al, 2012;Xu et al, 2012;McGuire et al, 2014b) of the DEJ, as well as postradiation changes (McGuire et al, 2014a).…”

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confidence: 99%

Type IV Collagen is a Novel DEJ Biomarker that is Reduced by Radiotherapy

McGuire¹,

Gorski

Dusevich³

et al. 2014

J Dent Res

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The dental basement membrane (BM) is composed of collagen types IV, VI, VII, and XVII, fibronectin, and laminin and plays an inductive role in epithelial-mesenchymal interactions during tooth development. The BM is degraded and removed during later-stage tooth morphogenesis; however, its original position defines the location of the dentinenamel junction (DEJ) in mature teeth. We recently demonstrated that type VII collagen is a novel component of the inner enamel organic matrix layer contiguous with the DEJ. Since it is frequently co-expressed with and forms functional complexes with type VII collagen, we hypothesized that type IV collagen should also be localized to the DEJ in mature human teeth. To identify collagen IV, we first evaluated defect-free erupted teeth from various donors. To investigate a possible stabilizing role, we also evaluated extracted teeth exposed to high-dose radiotherapy -teeth that manifest post-radiotherapy DEJ instability. We now show that type IV collagen is a component within the morphological DEJ of posterior and anterior teeth from individuals aged 18 to 80 yr. Confocal microscopy revealed that immunostained type IV collagen was restricted to the 5-to 10-µm-wide optical DEJ, while collagenase treatment or previous in vivo tooth-level exposure to > 60 Gray irradiation severely reduced immunoreactivity. This assignment was confirmed by Western blotting with whole-tooth crown and enamel extracts. Without reduction, type IV collagen contained macromolecular α-chains of 225 and 250 kDa. Compositionally, our results identify type IV collagen as the first macromolecular biomarker of the morphological DEJ of mature teeth. Given its network structure and propensity to stabilize the dermal-epidermal junction, we propose that a collagen-IV-enriched DEJ may, in part, explain its wellknown fracture toughness, crack propagation resistance, and stability. In contrast, loss of type IV collagen may represent a biochemical rationale for the DEJ instability observed following oral cancer radiotherapy.

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The distribution of carbonate in enamel and its correlation with structure and mechanical properties

Cited by 84 publications

References 39 publications

Chemistry and Bioactivity of NeoMTA Plus™ versus MTA Angelus® Root Repair Materials

Chemistry and Bioactivity of NeoMTA Plus™ versus MTA Angelus® Root Repair Materials

Chemical and mechanical properties of snake fangs

Type IV Collagen is a Novel DEJ Biomarker that is Reduced by Radiotherapy

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