The distribution of gastritis in carcinoma of the stomach

Plessis, Du

doi:10.1002/bjs.1800610706

Cited by 8 publications

(1 citation statement)

References 15 publications

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“…In fact, this has been demonstrated experimentally when reflux of duodenal contents into the stomach was shown to lead to all of the changes of chronic gastritis [4]. Intestinal metaplasia of the gastric mucosa is a change that has been attributed to reflux, and it has been suggested to also have an association with carcinoma [3,19,20]. If a causal relationship between these changes and carcinoma exists, it might be expected that some of the previously described studies would demonstrate it.…”

mentioning

confidence: 96%

Stump cancer following gastric surgery

Nicholls

1979

World j. surg.

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This paper reviews the literature regarding the development of gastric cancer in the stomach remnant following gastric resection. Although there is as yet little supporting experimental evidence, clinical studies suggest that the risk of developing gastric cancer is increased, perhaps as much as 6-fold, following partial gastrectomy for benign lesions. It also appears that the risk of developing cancer is greatest if the lesion for which the gastrectomy was originally performed was a gastric ulcer rather than a duodenal ulcer. The type of gastrectomy does not seem to influence this increased risk. Hypotheses are reviewed concerning the role of changes in gastric morphology following partial gastrectomy in the development of cancer.

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mentioning

confidence: 96%

Stump cancer following gastric surgery

Nicholls

1979

World j. surg.

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Atrophic chronic gastritis and intestinal metaplasia in gastric carcinoma. Comparison with a representative population sample

Sipponen

Kekki

Siurala

1983

Cancer

112

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The occurrence of chronic gastritis and intestinal metaplasia (IM) was studied in 257 patients with gastric carcinoma (GC). In all cases biopsies were available from the benign mucosal area adjacent to the tumor, and in 139 patients from the antrum and/or body mucosa outside the tumor. The results were compared with endoscopically and bioptically examined noncancer controls representing a large Finnish population sample. For every GC patient, a control subject was matched by age and sex. In addition, a mean age‐adjusted score (AAS) of chronic gastritis, which expresses the progression of gastritis in GC patients as compared with that in the general population, was calculated for GC patients. The prevalences of chronic and atrophic gastritis in the antrum and body mucosa were similar in GC patients and controls when carcinoma cases were not more specifically classified according to histologic type or location of tumors. On the other hand, the location of the tumor showed a significant relation to gastritis: the progression of gastritis was more rapid (high mean AAS value) and the prevalence of atrophic gastritis was higher in the tumor‐affected area (i.e., in the antrum in patients with antral [distal] tumors; in the body in patients with body [proximal] tumors), than in the general population, but were similar in the tumor‐free area in both GC patients and controls. In the intestinal type of GC (IGC), the prevalence of chronic gastritis was higher and its progression was more rapid than in controls. In the diffuse type of GC (DGC), these correlations were less distinct. In GC patients, the IM adjacent to and outside the tumor area was significantly more common and extensive than in the corresponding area of controls, and a significant positive correlation was present between the location of the tumor and the distribution of IM. Like gastritis, the IM showed a closer relationship to IGC than to DGC. In all cases of GC and particularly of IGC, the antral mucosa tended to be more severely affected by gastritis and IM than the body mucosa, i.e., the prevailing type of gastritis found in this GC series was that morphologically corresponding to the so‐called B‐type of chronic gastritis.

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Gastric carcinoma and previous peptic ulceration

Ellis

Kingston

Brookes

et al. 1979

Journal of British Surgery

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The incidence of patients with gastric carcinoma having had a previously diagnosed or suspected peptic ulcer was noted in two studies. These studies were the West Midlands Gastric Chemotherapy Trial (1974--6) and a retrospective study of patients presenting to the United Birmingham Hospitals with gastric carcinoma during the years 1958--62 and 1968--72. The incidence of patients found to have had a previous operation for duodenal ulcer or to have post-mortem evidence of one was 6.5 per cent and 5.7 per cent respectively. A radiologically proved duodenal ulcer had been identified in 5.5 per cent and 2.1 per cent respectively and the incidence of previous symptoms suggestive of a duodenal ulcer was 4.0 per cent and 5.2 per cent. These figures indicate the total incidence could be 12.97--16.0 per cent, which is much higher than previously reported. The mean time interval between operation for duodenal ulcer and the development of gastric carcinoma was much longer in patients having had a partial gastrectomy than in patients having had a vagotomy and drainage procedure. The incidence of previous benign gastric ulcers was 2.5 per cent and 0.9 per cent. Fifty-three per cent of patients having had a previous operation for duodenal ulceration were found to have an unresectable carcinoma, compared with the overall unresectable rate of 35 per cent.

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The distribution of gastritis in carcinoma of the stomach

Cited by 8 publications

References 15 publications

Stump cancer following gastric surgery

Stump cancer following gastric surgery

Atrophic chronic gastritis and intestinal metaplasia in gastric carcinoma. Comparison with a representative population sample

Gastric carcinoma and previous peptic ulceration

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