The distribution of genetic diversity of KIR genes in the Chinese Mongolian population

Wang, Hongdan; Zhang, Fei-xiong; Shen, Chunmei; Wu, Yuanming; Lv, Yonggang; Xie, Songtao; Yang, Guang; Qin, Haixia; Fan, Shuanliang; Zhu, Bofeng

doi:10.1016/j.humimm.2012.07.317

Cited by 11 publications

(6 citation statements)

References 28 publications

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“…KIR genes and KIR genotypes showed extensive genetic diversity in populations from different geographical regions and different ethnic groups [5, [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. The present study also confirmed this.…”

Section: Discussionsupporting

confidence: 82%

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Genetic polymorphisms and association of KIR-HLA system of Chinese Henan Han population and an extensive KIR gene diversity study between populations distributed worldwide

Wang¹,

Feng²,

Guo³

et al. 2018

Oncotarget

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Section: Discussionsupporting

confidence: 82%

“…The Heatmap analysis was drawn and presented in Figure 2 [5,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. The languages of the 23 populations belonged to SinoTibetan, Altaic, Austronesian and Indo-European language families.…”

Section: Kir Gene Diversities Of Populations Distributed Worldwidementioning

confidence: 99%

Genetic polymorphisms and association of KIR-HLA system of Chinese Henan Han population and an extensive KIR gene diversity study between populations distributed worldwide

Wang¹,

Feng²,

Guo³

et al. 2018

Oncotarget

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“…2018 ). High resolution analysis of KIR and HLA diversity across East Asian populations ( Wang et al. 2012 ; Bao et al.…”

Section: Discussionmentioning

confidence: 99%

“…Although less is known of KIR allele diversity in the Han, several studies established that the genes characteristic of KIR A haplotypes are common and demonstrated differences in their distribution among the different Han groups and among other resident populations ( Yao et al. 2011 , 2019 ; Wang et al. 2012 ; Bao et al.…”

Section: Introductionmentioning

confidence: 99%

Adaptive Admixture of HLA Class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians

Deng

Zhen

Harrison

et al. 2021

Molecular Biology and Evolution

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Human natural killer (NK) cells are essential for controlling infection, cancer and fetal development. NK cell functions are modulated by interactions between polymorphic inhibitory killer cell immunoglobulin-like receptors (KIR) and polymorphic HLA-A, -B and -C ligands expressed on tissue cells. All HLA-C alleles encode a KIR ligand and contribute to reproduction and immunity. In contrast, only some HLA-A and -B alleles encode KIR ligands and they focus on immunity. By high-resolution analysis of KIR and HLA-A, -B and -C genes, we show that the Chinese Southern Han are significantly enriched for interactions between inhibitory KIR and HLA-A and -B. This enrichment has had substantial input through population admixture with neighboring populations, who contributed HLA class I haplotypes expressing the KIR ligands B*46:01 and B*58:01, which subsequently rose to high frequency by natural selection. Consequently, over 80% of Southern Han HLA haplotypes encode more than one KIR ligand. Complementing the high number of KIR ligands, the Chinese Southern Han KIR locus combines a high frequency of genes expressing potent inhibitory KIR, with a low frequency of those expressing activating KIR. The Southern Han centromeric KIR region encodes strong, conserved, inhibitory HLA-C specific receptors, and the telomeric region provides a high number and diversity of inhibitory HLA-A and -B specific receptors. In all these characteristics, the Chinese Southern Han represent other East Asians, whose NK cell repertoires are thus enhanced in quantity, diversity and effector strength, likely augmenting resistance to endemic viral infections.

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“…This haplotype encodes two KIR ligands, HLA-B*58:01 and C*03:02 (Guethlein et al 2015). Although less is known of KIR allele diversity in the Han, several 6 studies established that the genes characteristic of KIR A haplotypes are common, and demonstrated differences in their distribution among the different Han groups and among other resident populations (Bao et al 2013;Wang et al 2012;Yao et al 2011). These studies also confirmed that KIR and HLA class I combinatorial diversity is an important factor in pregnancy syndromes, infectious disease, blood cancers and transplantation outcome in the Han.…”

Section: Introductionmentioning

confidence: 99%

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

Deng

Zhen

Harrison

et al. 2020

Preprint

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Human natural killer (NK) cells are essential for controlling infection, cancer and fetal development. NK cell functions are modulated by interactions between polymorphic inhibitory killer cell immunoglobulin-like receptors (KIR) and polymorphic HLA-A, -B and -C ligands expressed on tissue cells. All HLA-C alleles encode a KIR ligand and contribute to reproduction and immunity. In contrast, only some HLA-A and -B alleles encode KIR ligands and they focus on immunity. By high-resolution analysis of KIR and HLA-A, -B and -C genes, we show that the Chinese Southern Han are significantly enriched for interactions between inhibitory KIR and HLA-A and -B. This enrichment has had substantial input through population admixture with neighboring populations, who contributed HLA class I haplotypes expressing the KIR ligands B*46:01 and B*58:01, which subsequently rose to high frequency by natural selection. Consequently, over 80% of Southern Han HLA haplotypes encode more than one KIR ligand. Complementing the high number of KIR ligands, the Chinese Southern Han KIR locus combines a high frequency of genes expressing potent inhibitory KIR, with a low frequency of those expressing activating KIR. The Southern Han centromeric KIR region encodes strong, conserved, inhibitory HLA-C specific receptors, and the telomeric region provides a high number and diversity of inhibitory HLA-A and -B specific receptors. In all these characteristics, the Southern Han represent other East Asians, whose NK cell repertoires are thus enhanced in quantity, diversity and effector strength, likely through natural selection for resistance to endemic viral infections.

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The distribution of genetic diversity of KIR genes in the Chinese Mongolian population

Cited by 11 publications

References 28 publications

Genetic polymorphisms and association of KIR-HLA system of Chinese Henan Han population and an extensive KIR gene diversity study between populations distributed worldwide

Genetic polymorphisms and association of KIR-HLA system of Chinese Henan Han population and an extensive KIR gene diversity study between populations distributed worldwide

Adaptive Admixture of HLA Class I Allotypes Enhanced Genetically Determined Strength of Natural Killer Cells in East Asians

Genetically Determined Strength of Natural Killer Cells is Enhanced by Adaptive HLA class I Admixture in East Asians

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