The distribution of HLA‐A and ‐B antigens in patients and their families with periodontosis

Cullinan, M. P.; Sachs, J. A.; Wolf, Eva; Seymour, G. J.

doi:10.1111/j.1600-0765.1980.tb00272.x

Cited by 46 publications

(24 citation statements)

References 19 publications

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“…However, family studies of early-onset periodontal disease show that localized and generalized disease can occur in the same family , and that localized disease can progress to the generalized form . Some confusion has arisen from two small-family studies of HLA antigens and periodontal disease (Cullinan et al, 1980;Saxen and Koskimies, 1984). These studies have been mistakenly construed as being genetic linkage studies, which they were not.…”

Section: Population Association Studiesmentioning

confidence: 99%

Genetic Influences in Caries and Periodontal Diseases

Hassell

Harris

1995

Critical Reviews in Oral Biology & Medicine

116

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Deciphering the relative roles of heredity and environmental factors ("nature vs. nurture") in the pathogenesis of dental caries and diseases of the periodontium has occupied clinical and basic researchers for decades. Success in the endeavor has come more easily in the case of caries; the complex interactions that occur between host-response mechanisms and putative microbiologic pathogens in periodontal disease have made elucidation of genetic factors in disease susceptibility more difficult. In addition, during the 30-year period between 1958 and 1987, only meager resources were targeted toward the "nature" side of the nature/nurture dipole in periodontology. In this article, we present a brief history of the development of genetic epistemology, then describe the three main research mechanisms by which questions about the hereditary component of diseases in humans can be addressed. A critical discussion of the evidence for a hereditary component in caries susceptibility is next presented, also from a historical perspective. The evolution of knowledge concerning possible genetic ("endogenous", "idiotypic") factors in the pathogenesis of inflammatory periodontal disease is initiated with an analysis of some foreign-language (primarily German) literature that is likely to be unfamiliar to the reader. We identify a turning point at about 1960, when the periodontal research community turned away from genetics in favor of microbiology research. During the past five years, investigators have re-initiated the search for the hereditary component in susceptibility to common adult periodontal disease; this small but growing body of literature is reviewed. Recent applications of in vitro methods for genetic analyses in periodontal research are presented, with an eye toward a future in which persons who are at risk-genetically predisposed-to periodontal disease may be identified and targeted for interventive strategies. Critical is the realization that genes and environment do not act independently of each other; the appearance or magnitude of heritability may differ with various environments.

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Section: Population Association Studiesmentioning

confidence: 99%

Genetic Influences in Caries and Periodontal Diseases

Hassell

Harris

1995

Critical Reviews in Oral Biology & Medicine

116

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“…It is further stated that reading for pleasure refers to reading which is started at other's request then we continue since we are getting interested in. Reading for pleasure is defined as a reading in which students choose to do reading based on their own [19]. As been noted that reading has benefits such as learners' literacy competence is developed since they read for pleasure and learners who read and enjoy reading make them to be a literate [20].…”

Section: The Nature Of Teyl and Local Culture-based Picture Storybooksmentioning

confidence: 99%

Local culture-based picture storybooks for teaching English for young learners

Ratminingsih

Budasi

2018

SHS Web Conf.

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Abstract. This paper reports the theoretical perspectives underlying the development of local culture-based picture storybooks for teaching English for young learners. It is a library research which derives from three main sources, journal articles, reference books, and internet articles. Local culture-based picture storybooks are kinds of printed materials which basically contain stories adapted from local culture stories accompanied with visualization in the forms of pictures telling the characters and the settings to help young learners easily understand the stories. They are developed considering the good criteria of storybooks [1,2]. The benefits of its development are (1) to improve reading skill of young learners, (2) to build children English literacy through listening to the story read by the teachers and communicating interactively with them through dialogic reading, (3) create a fun learning atmosphere which enhances motivation and participation to take part in understanding and using the language, and (4) to preserve local culture. The books are developed using a combination of model [3,4] which has 5 main steps namely need analysis, developing product, expert validation, and quality assessment by experts and users (teachers), and main product revision.

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“…Moreover, no linkage disequilibrium seemed to exist between associated alleles. The positive association of HLA-A9 and HLA-B15 with AP in Caucasians [10,12,13] but not in Lebanese is also probably accounted for by the ethnic differences between the two populations. In addition, HLADRB1*13 seemed to have a more frequent occurrence in patients with AP that are Germans of Caucasian descent [26] and HLA-B*15 was also found to be associated with AP in Indian population [27].…”

Section: Discussionmentioning

confidence: 99%

“…Genetic factors such as the Human Leukocyte Antigen (HLA) alleles, have been reported to correlate with pre-disposition to or protection against several diseases including periodontitis [9][10][11]. In particular, HLA-A9 and HLA-B15 seem consistently associated with aggressive periodontitis in Caucasians [10,12,13], while HLA-A2, HLA-B5 and HLA-A28 are potential protective factors against periodontitis among Caucasians [10,14]. However, studies involving HLAperiodontitis association in the Lebanese ethnic group are lacking.…”

Section: Introductionmentioning

confidence: 92%