The distribution of NPY-like immunoreactivity in the chameleon brain

Abstract

The distribution of neuropeptide Y (NPY) immunoreactivity was studied in the brain of the chameleon. Cell bodies and fibers displaying NPY-like immunoreactivity were widely dispersed throughout the brain and at the highest density in the telencephalon and diencephalon. Immunolabeled cell bodies were numerous in the medial and dorsomedial cortex and in the dorsal ventricular ridge, while the striatum and basal telencephalon only contained sparsely scattered NPY-positive somata. Immunopositive neurons were densely distributed in the dorsal thalamus (particularly in the perirotundal belt), the area triangularis, the nucleus geniculatus lateralis pars dorsalis, the periventricular hypothalamus and the medial eminence. In the pretectum, NPY-immunoreactive cell bodies were limited to the nucleus posterodorsalis, while in the mesencephalon immunolabeled somata were found in the stratum album centrale of the optic tectum and in the substantia nigra. Immunopositive fibers and terminals were particularly dense in the dorsomedial cortex, the periventricular hypothalamus, the nuclei accumbens, suprachiasmaticus and griseus tectalis, in the substantia nigra and in the torus semicircularis. These findings show that the NPY system in the chameleon has the same basic organization as in other vertebrate species, and indicate that this peptide could be also implicated in the regulation of several aspects of cerebral functions. In addition, and of particular interest, is the observation of numerous NPY-immunoreactive neurons and fibers in several visual nuclei, suggesting an important involvement of this substance in the visual function.

Neuropeptide Y in the olfactory system, forebrain and pituitary of the teleost, Clarias batrachus

“…Peptide was also widely encountered in telencephalon of tetrapods (mammals: Chronwall et al, 1985;birds: Gould et al, 2001;den Boer-Visser and Dubbeldam, 2002;reptiles: Medina et al, 1992;Bennis et al, 2001;amphibians: Danger et al, 1985;Lazar et al, 1993;Ebersole et al, 2001).…”

“…Vd in the telencephalon of teleosts corresponds to striatum/basal ganglia of higher vertebrates (Reiner and Northcutt, 1992). NPY immunoreactive cells were described in the corresponding areas in mammals (de Quidt and Emson, 1986), birds (Anderson and Reiner, 1990;Esposito et al, 2001), reptiles (Medina et al, 1992;Bennis et al, 2001) and amphibians (Tuinhof et al, 1993;Ebersole et al, 2001).…”

Chemoarchitectonic subdivisions of the songbird septum and a comparative overview of septum chemical anatomy in jawed vertebrates

“…Unfortunately, reports for other species typically describe NPY-ir fiber distributions for the whole brain, and little specific information is provided on the septum; thus the present data can be compared with that for other groups only on a gross basis. In general, NPY-ir fibers are widely distributed in the vertebrate septum, encompassing both medial and lateral divisions, e.g., birds (Coturnix japonica, Aste et al, 1991; Parus sp., Gould et al, 2001), mammals (Mecrocebus murinus, Bons et al, 1990; Spermophilus sp., Reuss et al, 1990), reptiles (Gallotia gallotii, Medina et al, 1992; Podarcis hispanica, Salom et al, 1994; Chamaeleo chameleon, Bennis et al, 2001), and amphibians (Triturus cristatus, Perroteau et al, 1988;Xenopus laevis, Tuinhof et al, 1994; Typhlonectes natans, Ebersole et al, 2001). An expansive NPY-ir innervation of the septum therefore appears to be a ubiquitous tetrapod feature, although there are large species differences in the presence and location of NPY-ir perikarya.…”

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

“…3). The meAMY also receives input from Khachaturian et al, 1983;Hökfelt et al, 1984;Johansson et al, 1984;McDonald, 1984;Ottersen and Storm-Mathisen, 1984;Shults et al, 1984;Wainer et al, 1984;Nakagawa et al, 1985;Onteniente et al, 1986;Resibois and Rogers, 1992;Sun and Cassell, 1993;Gotti et al, 2005;Flames et al, 2007;Birds: Takatsuki et al, 1981;Domenici et al, 1988;Anderson and Reiner, 1990a;Medina and Reiner, 1994;Veenman and Reiner, 1994;Moons et al, 1995;Atoji et al, 2001;den Boer-Visser and Dubbeldam, 2002;Roberts et al, 2002;Goodson et al, 2004;Husband and Shimizu, 2011;Reptiles: Brauth, 1984;Weindl et al, 1984;Bennis et al, 1991a,b;Medina et al, 1993;Smeets, 1994;Smeets et al, 1997;Bennis et al, 2001;O'Connell et al, 2011d;Amphibians: Franzoni and Morino, 1989;Gonzalez et al, 1993;Gonzalez and Smeets, 1993;Marin et al, 1997bMarin et al, , 1998bTeleosts: Roberts et al, 1989;Sas and Maler, 1991;Vecino et al, 1992;Weld and Maler, 1992;Perez et al, 2000;Castro ...…”