The Distribution of Polyamine Oxidase Activity in the Fetomaternal Compartments

Illei, G; Morgan, David M. L.

doi:10.1111/j.1471-0528.1979.tb10714.x

Cited by 29 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whether indeed we are dealing with a single enzyme protein with broad substrate specificity or a family of enzymes is for the most part not known with certainty (see Morgan, 1983). Amine oxidase activity has been detected as DAO with putrescine as substrate (Gahl et al, 1982a;Southren et al, 1964), polyamine oxidase (PAO) with spermine as substrate (Dlei and Morgan, 1979), histaminase with histamine as substrate (Beavan et al, 1975) and spermidine oxidase with spermine as substrate (Gahl et al, 1982a). Amine oxidase has been purified and characterized from a number of sources including maternal serum (Illei and Morgan, 1979;Gahl et al, 1982a), maternal plasma (Baylin and Margolis, 1975), amniotic fluid (Tujvesson, 1978), and term placental tissue (Smith, 1967;Paolucci«ai., 1971;Bardsley etal., 1974;Crabbe etal., 1976) (see Morgan, 1983).…”

Section: Scbeumentioning

confidence: 97%

Secretory endometrial and decidual proteins: studies and clinical significance of a maternally derived group of pregnancy-associated serum proteins

Bell

1986

Human Reproduction

View full text Add to dashboard Cite

In contrast to our ability to monitor placental function during pregnancy, due to the availability of a range of placentally derived secretory products such as HCG, HPL, SP1, PAPP-A, etc. the equivalent monitoring of the endometrial function in implantation and pregnancy has been impaired by a lack of equivalent endometrial products. Decidual diamine oxidase and prolactin have been extensively characterized but each have clinical drawbacks and may indeed be minor products of the endometrium. Recent developments in the characterization of the major secretory protein products of the endometrium, and a re-assessment of the origin of a number of placental proteins, radically alter our ability to monitor endometrial function, offer a new clinical window on pregnancy and might provide new knowledge on the extent of feto-maternal dialogue at implantation and during pregnancy. In this review, aspects of many scientific studies, and the function and possible clinical significance of these endometrial and decidual protein products are assessed.

show abstract

Section: Scbeumentioning

confidence: 97%

Secretory endometrial and decidual proteins: studies and clinical significance of a maternally derived group of pregnancy-associated serum proteins

Bell

1986

Human Reproduction

View full text Add to dashboard Cite

show abstract

“…Spermine oxidase (SMOX), an enzyme that preferentially oxidizes spermine, a polyamine involved in cellular metabolism and suggested to play a role in immune privilege in the decidua [32], increased 17.4-fold in cAMP-treated MSC compared to cells treated with vehicle for 14 days. It was also 5.8-fold up-regulated in hESF in response to cAMP (Table 1) [23].…”

Section: Comparison Of Response To 8-br-camp In Msc Versus Hesfmentioning

confidence: 99%

The Bone Marrow-Derived Human Mesenchymal Stem Cell: Potential Progenitor of the Endometrial Stromal Fibroblast1

Aghajanova

Horcajadas

Esteban

et al. 2010

Biology of Reproduction

View full text Add to dashboard Cite

The cellular sources that contribute to the renewal of human endometrium are largely unknown. It has been suggested that endometrial stem cells originate from bone marrow-derived mesenchymal stem cells (MSC), with subsequent development into endometrial stromal fibroblasts (hESF). We hypothesized that if bone marrow-derived MSC contribute to endometrial regeneration and are progenitors of hESF, their treatment with agents known to regulate hESF differentiation could promote their differentiation down the stromal fibroblast lineage. To this end, we treated bone marrow-derived MSC with estradiol and progesterone, bone morphogenetic protein 2 (BMP2), and activators of the protein kinase A (PKA) pathway and investigated specific markers of hESF differentiation (decidualization). Furthermore, we investigated the transcriptome of these cells in response to cAMP and compared this to the transcriptome of hESF decidualized in response to activation of the PKA pathway. The data support the idea that MSC can be differentiated down the hESF pathway, as evidenced by changes in cell shape and common expression of decidual markers and other genes important in hESF differentiation and function, and that bone marrow-derived MSC may be a source of endometrial stem/progenitor cells. In addition, we identified MSC-specific markers that distinguish them from other fibroblasts and, in particular, from hESF, which is of biologic relevance and practical value to the field of endometrial stem cell research.

show abstract

“…We have previously suggested that the enzyme in sufficient concentrations may constitute an important part of a supposed local immunological barrier formed at the placental bed to protect the fetal allograft from maternal immune rejection through a local suppressive effect on maternal cellular immunity. The P A 0 activity found in the maternal circulation might be the consequence of a leakage, rather than secretion, into the maternal blood (Illei and Morgan, 19796) and might not be high enough to cause a generalized suppression of the maternal cellular immunity. We have also shown that the enzyme activity of decidua is significantly higher than that of placenta.…”

Section: Discussionmentioning

confidence: 96%

“…It has also been shown that in the retroplacental serum (mainly of intervillous origin) the P A 0 activity is 20 to 30 times higher than in the maternal uterine or cubital venous blood serum. No activity was found in fetal cord blood serum and preliminary data indicate that the enzyme might be produced by the decidua rather than by the placenta (Illei and Morgan, 19796). Recent only in retroplacental serum, is able to inhibit the spontaneous proliferation of lymphocytes in vitro (Morgan and Illei, 1980a).…”

mentioning

confidence: 99%

Polyamine Oxidase Activity in Amniotic Fluid and Fetal Membranes

Illei

Morgan

1980

BJOG

Self Cite

View full text Add to dashboard Cite

Summary Polyamine oxidase activity, already shown to be present in maternal serum, was measured in amniotic fluid between 15 and 40 weeks of gestation in 38 samples. The enzyme activity increased as pregnancy progressed, the levels being lower than those found in the maternal serum. Homogenates of chorion, amnion, separately and together, also showed the presence of enzyme activity, the levels being lower than those previously found in the decidua, but substantially higher than those found in the placenta. It is suggested that the enzyme found in amniotic fluid might be the consequence of a diffusion from the decidua through the membranes.

show abstract

The Distribution of Polyamine Oxidase Activity in the Fetomaternal Compartments

Cited by 29 publications

References 19 publications

Secretory endometrial and decidual proteins: studies and clinical significance of a maternally derived group of pregnancy-associated serum proteins

Secretory endometrial and decidual proteins: studies and clinical significance of a maternally derived group of pregnancy-associated serum proteins

The Bone Marrow-Derived Human Mesenchymal Stem Cell: Potential Progenitor of the Endometrial Stromal Fibroblast1

Polyamine Oxidase Activity in Amniotic Fluid and Fetal Membranes

Contact Info

Product

Resources

About