“…Intracellular estimates suggest that cytosolic sodium concentrations are ϳ5 mM, although concentrations approaching 12 mM have been reported (23,34,47,48). It appears that sodium concentrations vary among intracellular compartments; for example, endoplasmic reticulum, mitochondrial, and nuclear concentrations have been estimated to be ϳ27, 10 -50, and 108 mM (or higher), respectively (3,8,19,27,35). From these estimates, it appears that a sodium concentration gradient exists between the luminal contents of organelles and the cytosol.…”