The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C.

Abstract

Abstract. We have isolated a cDNA encoding mouse tenascin-X (TN-X), a new member of the family of tenascin genes. The TN-X gene lies in the major histocompatibility complex (MHC) class HI region, as it is the case for its human counterpart. On Northern blots we detected a TN-X mRNA of "013 kb in most tissues analyzed, whereas in various mouse cell lines mRNAs of "011 and 13 kb were detected, suggesting the possibility of alternative splicing of TN-X transcripts. We raised antibodies against mouse TN-X

Joint hypermobility syndromes: The pathophysiologic role of tenascin‐X gene defects

“…In developing rats, tenascin-X is expressed in tendon sheaths, ligaments, synovium, muscle, epicardium, and blood vessel adventitia (48), and a similar distribution has also been shown for pigs (49). In mice, tenascin-C and tenascin-X are coexpressed in muscle, gut, skin, and vasculature (50). Despite many in vitro studies suggesting an important role for tenascin-C in the pathogenesis of different diseases, tenascin-Cknockout mice do not have a clear phenotype, indicating no essential role of tenascin-C in connective tissue biology or wound healing (51), and the tenascin-Rknockout mice have only a mild phenotype.…”

Embryonic expression of tenascin‐X suggests a role in limb, muscle, and heart development

“…The pattern of expression we report here, especially its early expression in developing heart, is consistent with this hypothesis. This concept is further strengthened by the observation that this protein is highly conserved in human, mouse, rat, and swine (Burghelle-Mayeur et al, 1992;Matsumoto et al, 1994;Chaplin et al, 1986;Bristow et al, 1993b). In each of these species, the TN-X gene overlaps one of the duplicated 21-hydroxylase genes, and this overlap has provided genetic evidence supporting the importance of the TN-X gene.…”

“…The tenascins are a family of extracellular matrix glycoproteins that are expressed in distinct embryonic patterns and that may have important functions during vertebrate development (Erickson, 1993;ChiquetEhrismann et al, 1994). Family members share a modular structure consisting of a carboxy-terminal fibrinogen-like domain, a variable number of repeats similar to the type I11 repeats of fibronectin, a cysteine rich epidermal growth factor-like domain, and a n 0 1995 WILEY-LISS, INC.…”

Tenascin‐X, collagen, elastin, and the Ehlers–Danlos syndrome

“…Reports of the complete human gene and mouse cDNA soon followed, and included studies of expression that were consistent with important roles in development and matrix biology [2,4,21]. However, the large size of the encoded mRNA (12 kb) and protein (450 kD) impeded functional studies and suggested to us that genetic strategies were most likely to identify unique functions for TNX.…”