The Distribution of the Human Blood Groups

Mourant, A. E.

doi:10.1097/00007611-195508000-00026

Cited by 200 publications

(177 citation statements)

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“…The G6PD gene is known to be polymorphic in areas where malaria is endemic. In some areas of Saudi Arabia the frequency of G6PD deficiency genes is about 0.50 (Mourant et al, 1976). Since the heterozygotes for this gene cannot be identified, we can see from formula (3) that 37.5 percent of hemophiliac males in this area Can Table 2.…”

Section: (3) Abo Blood Groups As Markersmentioning

confidence: 99%

Proportion of informative families for genetic counseling with linked marker genes

Nei

1979

Jap J Human Genet

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SummaryThe utility of linked marker genes for genetic counseling depends on the gene frequencies and dominance relationship at the marker locus as well as on the recombination value between the marker and disease gene loci. A quantity called the proportion of informative families was introduced to measure the effect of gene frequencies and dominance relationship on the utility of marker genes. This proportion is higher for X-linked genes than for autosomal genes, other things being equal. It is also higher for codominant markers than for marker genes with dominance. It is shown that when gene frequencies are appropriate linked marker genes are quite useful for genetic counseling. Examples are given by using real data on G6PD, colorblindness, the ABO blood groups, etc.

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Section: (3) Abo Blood Groups As Markersmentioning

confidence: 99%

Proportion of informative families for genetic counseling with linked marker genes

Nei

1979

Jap J Human Genet

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“…Later antigen Le b was discovered, and the four Lewis phenotypes: Le(aÀbÀ), Le(a þ bÀ), Le(aÀb þ ) and Le(a þ b þ ) were established. 1 The phenotype expression is determined by two genetic systems closely related on the short arm of chromosome 19, the Lewis genes Le and le, and the Secretor genes, Se and se. The gene product consists of various fucosyl transferases, which from tissue liquids are adsorbed onto cell surfaces.…”

Section: Introductionmentioning

confidence: 99%

“…The gene product consists of various fucosyl transferases, which from tissue liquids are adsorbed onto cell surfaces. 1 Le(aÀbÀ) individuals lack alpha (1,3/1,4) fucosyltransferase activity. 2 Almost 10% belong to this phenotype in the Danish as well as in most other Caucasian populations.…”

Section: Introductionmentioning

confidence: 99%

“…2 Almost 10% belong to this phenotype in the Danish as well as in most other Caucasian populations. 1 It has been shown, that Le(aÀbÀ) subjects have a slightly higher mean body mass index, 3 a higher weight gain over time, 4 a higher prevalence and incidence of ischemic heart disease, 3,5,6 a higher prevalence of type 2 diabetes, 7 and a higher prevalence of features of the insulin resistance syndrome. 8 A study focusing specifically on the possible association between Lewis phenotypes and obesity is lacking.…”

Section: Introductionmentioning

confidence: 99%

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The Lewis blood group—a new genetic marker of obesity

2005

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In a cross-sectional epidemiological study including 3290 men aged 53-75 y, mean ¼ 63, we tested the hypothesis that the Lewis phenotype Le(aÀbÀ) is a genetic marker of obesity. All men were Lewis typed and measurements were made of height, weight, neck circumference, and hip fat fold. Obesity was defined as a body mass index Z30 kg/m 2 . Totally 291 men (8.8%) were obese; 9.6% of the men had the Le(aÀbÀ) phenotype. Le(aÀbÀ) men had a higher prevalence of obesity than others, 15.6 vs 8.1%, odds ratio (95% confidence interval): 2.1(1.5-2.9), Po0.001. The etiological fraction, that is, the excess prevalence of obesity in the study population due to the Le(aÀbÀ) phenotype, was approximately 10%. The frequency of the Le(aÀbÀ) phenotype may vary substantially in different populations. Identification of this new genetic marker of obesity may, for example, contribute to the explanation of individual and ethnic differences in the prevalence of obesity.

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“…The current issue for "The Distribution of the Human Blood Groups and Other Polymorphisms" (Mourant et al, 1976) contains data on over 60 kinds of polymorphic traits, based upon newly developed immunochemical and electrophoretic techniques. The study of genetic polymorphisms has greatly contributed to our knowledge not only of the genetic characteristics of a given individual and population but of our understandings of evolutionary changes of protein molecules and population structure.…”

mentioning

confidence: 99%