The distribution of total and specific serum IgE in the European Community Respiratory Health Survey☆, ☆☆, ★

Burney, Peter; Malmberg, E; Chinn, Susan; Jarvis, Déborah; Luczynska, Christina; Lai, Eric

doi:10.1016/s0091-6749(97)70048-4

Cited by 253 publications

(203 citation statements)

References 20 publications

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“…In contrast to the sex differences in atopy assessed as skin test positivity which vary and change direction across the human lifespan, sex differences in atopy assessed as total serum IgE levels are consistent across the lifespan, with levels in females being lower than those in males (21). With reference to asthma and food allergy, prevalence is higher in boys before puberty, while this sex ratio is reportedly reversed after puberty (22).…”

Section: Sex Differences and Food Allergymentioning

confidence: 87%

Incorporating a gender dimension in food allergy research: a review

DunnGalvin

Hourihane

Frewer

et al. 2006

Allergy

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Sex and gender are the major determinants of health and disease in both men and women. The aim of this review paper was to examine differences in gender and sex in relation to the prevalence and effects of food allergy. There are still major gaps in our knowledge about the kinds of processes which shape men's and women's perceptions and experiences of food allergy. The expression and experience of health and illness may be moderated by variables such as biological vulnerability, exposure to health risks, perception of symptoms, evaluation of risk, information processing and role expectations. This review highlights the complex links between biological sex, gender, and health in general and offers a synthesis of how these may interact to produce sex and gender differences in biopsychosocial manifestations of food allergy. Implications for research and public health practice are discussed.

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Section: Sex Differences and Food Allergymentioning

confidence: 87%

Incorporating a gender dimension in food allergy research: a review

DunnGalvin

Hourihane

Frewer

et al. 2006

Allergy

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“…The same observations were reported in the ECRHS studies conducted at 30 sites, mostly in Europe. 5,[13][14][15][16] Many studies have also explored the utility of total serum IgE as a marker of atopy and found some level of discordance with allergen-specific tests. 3,17 In this study, 21% of patients had a positive allergen-specific test while exhibiting normal total IgE.…”

Section: Discussionmentioning

confidence: 99%

Sensitization to Common Allergens in Adults with Asthma

Allen‐Ramey¹,

Schoenwetter²,

Weiss³

et al. 2005

The Journal of the American Board of Family Medicine

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Purpose: To estimate the prevalence of atopy (ie, allergen sensitization) in a sample of adult asthma outpatients.Methods: Population consisted of a total of 218 patients, 18 to 55 years of age, who were currently receiving care for asthma; and 13 physicians, whose specialties were Family Practice, Allergy, or Pulmonology and who were providing care to at least 10 to 15 asthma patients weekly. Patients provided a blood sample for quantification of total and allergen-specific IgE. Outcomes were the proportion of patients with atopy and the proportions of patients with elevated serum IgE specific to each of 8 specific common allergens.Results: The patients' mean age was 42 years, and 74% were women; 68% of patients met the study definition of atopy. Total serum IgE > 114 kU/L was observed in 48% of patients, and 59% had elevated levels of IgE specific to one or more of 8 common allergens.Conclusions: The majority of adult asthma outpatients had evidence of atopy and most were sensitive to a specific identifiable allergen. Awareness of the high prevalence of atopy among asthma patients might improve patient management. (J Am Board Fam Pract 2005;18:434 -9.)

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“…It has been noted previously that centres in Englishspeaking Western countries in the International Study of Asthma and Allergies in Childhood and the European Community Respiratory Health Survey tend to have some of the highest prevalences of atopic symptoms, bronchial responsiveness and atopy, a phenomenon which has hitherto been unexplained [1,17,18,25]. Interestingly, these countries also appear to have some of the highest paracetamol sales (>20 g .…”

Section: The Anglophone Linkmentioning

confidence: 99%

“…In phase 2, random samples of phase 1 respondents from some of the centres were assessed in greater detail. A smoking history was obtained, spirometry and bronchial challenge with methacholine (35 centres) were carried out [17], and total and specific immunoglobulin E (IgE) levels (37 centres) were measured [18]. Bronchial responsiveness was measured as a methacholine dose/response "slope", expressed in ECRHS units [17].…”

Section: Outcome Measures In Adults: the European Community Respiratomentioning

confidence: 99%

“…Atopy was defined as a specific IgE titre of >0.35 kU . L -1 to any of the four common allergens tested in each centre, namely Dermatophagoides pteronyssinus, timothy grass, cat and Cladosporium herbarium [18]. For each centre, arithmetic mean "slope", geometric mean IgE level and prevalence of atopy, standardized by sex, age (<30 or $30 yrs) and smoking (current smokers or nonsmokers) to a hypothetical standard population, were calculated.…”

Section: Outcome Measures In Adults: the European Community Respiratomentioning

confidence: 99%

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Paracetamol sales and atopic disease in children and adults: an ecological analysis

Newson¹,

Shaheen²,

Chinn³

et al. 2000

Eur Respir J

133

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The authors recently observed that frequent paracetamol use was positively associated with asthma and rhinitis in young adults. Therefore, an ecological analysis was performed to measure international associations between paracetamol sales and atopic disease prevalences in children and adults.Published data from the International Study of Asthma and Allergies in Childhood (ISAAC) on the prevalence of four atopic symptoms in 13±14-yr-olds (112 centres) and 6±7-yr-olds (66 centres) in 1994/1995, and European Community Respiratory Health Survey (ECRHS) data on the prevalence of asthma symptoms, diagnosed asthma and rhinitis (44 centres), prevalence of atopy, mean bronchial responsiveness and mean total immunoglobulin E levels (34 centres) in young adults in 1991/1992, were used. Their associations with national 1994/1995 per capita paracetamol sales were measured using linear regression.Paracetamol sales were high in English-speaking countries, and were positively associated with asthma symptoms, eczema and allergic rhinoconjunctivitis in 13±14-yr-olds, and with wheeze, diagnosed asthma, rhinitis and bronchial responsiveness in adults. The prevalence of wheeze increased by 0.52% in 13±14-yr-olds and by 0.26% in adults (p<0.0005) for each gram increase in per capita paracetamol sales.These ecological findings require cautious interpretation, but raise the possibility that variation in paracetamol usage may explain some of the variation in atopic disease prevalence between countries.

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The distribution of total and specific serum IgE in the European Community Respiratory Health Survey☆, ☆☆, ★

Cited by 253 publications

References 20 publications

Incorporating a gender dimension in food allergy research: a review

Incorporating a gender dimension in food allergy research: a review

Sensitization to Common Allergens in Adults with Asthma

Paracetamol sales and atopic disease in children and adults: an ecological analysis

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